LMTD2_MOUSE
ID LMTD2_MOUSE Reviewed; 664 AA.
AC Q0VET5; Q9CW10;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=Lamin tail domain-containing protein 2;
GN Name=Lmntd2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 465-664.
RC STRAIN=C57BL/6J; TISSUE=Placenta;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
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DR EMBL; BC119093; AAI19094.1; -; mRNA.
DR EMBL; BC119119; AAI19120.1; -; mRNA.
DR EMBL; AK005476; BAB24066.1; -; mRNA.
DR CCDS; CCDS40181.1; -.
DR RefSeq; NP_082326.1; NM_028050.2.
DR RefSeq; XP_006536319.1; XM_006536256.3.
DR AlphaFoldDB; Q0VET5; -.
DR SMR; Q0VET5; -.
DR STRING; 10090.ENSMUSP00000130905; -.
DR iPTMnet; Q0VET5; -.
DR PhosphoSitePlus; Q0VET5; -.
DR PaxDb; Q0VET5; -.
DR PRIDE; Q0VET5; -.
DR ProteomicsDB; 286225; -.
DR Antibodypedia; 70549; 9 antibodies from 4 providers.
DR Ensembl; ENSMUST00000026573; ENSMUSP00000026573; ENSMUSG00000025500.
DR GeneID; 72000; -.
DR KEGG; mmu:72000; -.
DR UCSC; uc009kjz.1; mouse.
DR CTD; 256329; -.
DR MGI; MGI:1919250; Lmntd2.
DR VEuPathDB; HostDB:ENSMUSG00000025500; -.
DR eggNOG; KOG0977; Eukaryota.
DR GeneTree; ENSGT00390000012150; -.
DR HOGENOM; CLU_432519_0_0_1; -.
DR InParanoid; Q0VET5; -.
DR OMA; VWGEGTR; -.
DR BioGRID-ORCS; 72000; 0 hits in 72 CRISPR screens.
DR PRO; PR:Q0VET5; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q0VET5; protein.
DR Bgee; ENSMUSG00000025500; Expressed in seminiferous tubule of testis and 100 other tissues.
DR ExpressionAtlas; Q0VET5; baseline and differential.
DR Genevisible; Q0VET5; MM.
DR GO; GO:0005638; C:lamin filament; IBA:GO_Central.
DR GO; GO:0030527; F:structural constituent of chromatin; IBA:GO_Central.
DR GO; GO:0048026; P:positive regulation of mRNA splicing, via spliceosome; IMP:MGI.
DR GO; GO:0010847; P:regulation of chromatin assembly; IBA:GO_Central.
DR Gene3D; 2.60.40.1260; -; 1.
DR InterPro; IPR001322; Lamin_tail_dom.
DR InterPro; IPR036415; Lamin_tail_dom_sf.
DR Pfam; PF00932; LTD; 1.
DR SUPFAM; SSF74853; SSF74853; 1.
DR PROSITE; PS51841; LTD; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Reference proteome.
FT CHAIN 1..664
FT /note="Lamin tail domain-containing protein 2"
FT /id="PRO_0000251930"
FT DOMAIN 362..481
FT /note="LTD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01187"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 245..272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 286..329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 504..563
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 118..169
FT /evidence="ECO:0000255"
FT COMPBIAS 245..262
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 543..557
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 664 AA; 73784 MW; 21102D4E4DAD68B7 CRC64;
MAPKSCQESE DKQVSPAPAG VQPDSSDLGS PVGTPVDRVA PSYSQSAKLY TSTPMGCSVK
QQLAPETLDP RTLRLLWEQR ELEIQALRWA VQNGHNARYS SILQEVAGVP SERNSKSQDK
FLRNQVQKLT LELKAQKEQA QQEKQQLEEK LQQNLWAKQQ LEAELQTFQK SCLLQLARSS
WVGRVLRSQT GSVEVVTTEV LRDPSDFSES AEIPTSGEGF PLEDVDWNSI AQRYPNLFSN
LNFYSDQKQS QPPTSETYTL DSEGATKHTE KPTKILEWSA LPLLDTSSSE RTQSDTSSCP
IALHSGAKKT TGHPSQGTNL ASSEQMQEHT RSFSGYTEDL CKSHSPSCSK TVLESYTDLH
HPYTRPQLNP FGCCLKIAAV SHREKFIRVI NQSQAETIDL GGFVLQQLVR DFPVCMYRFP
PGTLLAPQHH ITVWGEGTSR TKKQLPVASG QDPFQFQSSR GCVTVLVNPQ GQVLSEHQAT
PCVTLGSKIF TDNTDWSIDC FPLSESEPDV HPGEQQCRPS SPQKGRAKDA GARRKKPGPG
VRQHRHSSTS GLRASRTLHP TETRDILPLL SSRKLLPSGE VLTQQEGVKA ETSELLPVIP
ECPSRLCLGE DSLGRQEYKV QVCRKSVDLS CPMVALSVQN TAESRYGFRF LCYPPITEEL
CRRL
