LMX1B_CHICK
ID LMX1B_CHICK Reviewed; 400 AA.
AC P53413;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2013, sequence version 2.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=LIM/homeobox protein LMX-1.2;
DE Short=Homeobox protein LMX-1;
DE Short=LIM/homeobox protein 1;
DE Short=LMX;
GN Name=LMX1B; Synonyms=LMX, LMX1;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Spinal cord;
RX PubMed=7585966; DOI=10.1016/0092-8674(95)90103-5;
RA Riddle R.D., Ensini M., Nelson C., Tsuchida T., Jessell T.M., Tabin C.;
RT "Induction of the LIM homeobox gene Lmx1 by WNT7a establishes dorsoventral
RT pattern in the vertebrate limb.";
RL Cell 83:631-640(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 24-400.
RC STRAIN=White leghorn; TISSUE=Limb bud;
RX PubMed=7501017; DOI=10.1038/378716a0;
RA Vogel A., Rodriguez C., Warnken W., Izpisua-Belmonte J.-C.;
RT "Dorsal cell fate specified by chick Lmx1 during vertebrate limb
RT development.";
RL Nature 378:716-720(1995).
CC -!- FUNCTION: Specifies dorsal cell fate during limb development.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA84995.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAA96240.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; L39880; AAA96240.1; ALT_INIT; mRNA.
DR EMBL; U41823; AAA84995.1; ALT_INIT; mRNA.
DR RefSeq; NP_990689.2; NM_205358.1.
DR AlphaFoldDB; P53413; -.
DR SMR; P53413; -.
DR STRING; 9031.ENSGALP00000001374; -.
DR PaxDb; P53413; -.
DR Ensembl; ENSGALT00000078478; ENSGALP00000054070; ENSGALG00000040582.
DR GeneID; 396312; -.
DR KEGG; gga:396312; -.
DR CTD; 4010; -.
DR VEuPathDB; HostDB:geneid_396312; -.
DR eggNOG; KOG0490; Eukaryota.
DR GeneTree; ENSGT00940000157955; -.
DR InParanoid; P53413; -.
DR OMA; LLCKVDY; -.
DR OrthoDB; 737134at2759; -.
DR PRO; PR:P53413; -.
DR Proteomes; UP000000539; Chromosome 17.
DR Bgee; ENSGALG00000040582; Expressed in kidney.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0072164; P:mesonephric tubule development; IEP:AgBase.
DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR001781; Znf_LIM.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF00412; LIM; 2.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00132; LIM; 2.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR PROSITE; PS50023; LIM_DOMAIN_2; 2.
PE 2: Evidence at transcript level;
KW Activator; Developmental protein; DNA-binding; Homeobox; LIM domain;
KW Metal-binding; Nucleus; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Zinc.
FT CHAIN 1..400
FT /note="LIM/homeobox protein LMX-1.2"
FT /id="PRO_0000075831"
FT DOMAIN 56..106
FT /note="LIM zinc-binding 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DOMAIN 115..168
FT /note="LIM zinc-binding 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DNA_BIND 218..277
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 176..226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 207..221
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 279
FT /note="R -> S (in Ref. 2; AAA84995)"
FT /evidence="ECO:0000305"
FT CONFLICT 389
FT /note="R -> S (in Ref. 2; AAA84995)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 400 AA; 45027 MW; C67D4BA324ABF06C CRC64;
MDIASGPESL ERCFPRGPTD CAKMLDGIKM EDHPLRSGPA TLGVLLGSEC PHQAVCEGCQ
RPISDRFLMR VNESSWHEEC LQCAVCQQAL TTSCYFRDRK LYCKQDYQQL FAAKCSGCME
KIAPTEFVMR ALECVYHLSC FCCCVCERQL RKGDEFVLKE GQLLCKSDYE KEKDLLSSVS
PDDSDSVKSD DEDGDVKPTK GQVTQGKGSD DGKDPRRPKR PRTILTTQQR RAFKASFEVS
SKPCRKVRET LAAETGLSVR VVQVWFQNQR AKMKKLARRH QQQQEQQNSQ RLGQEVMSNR
MEGMMTSYTP LAPPQQQIVA MDQSSYGTDP FQQGLTPPQM PGDHMNPYGN DSIFHDIDSD
TSLTSLSDCF LASSEVNSMQ ARVGNPIDRL YSMQSSYFAS
