ID   LMX1B_MESAU             Reviewed;         369 AA.
AC   Q60564;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=LIM homeobox transcription factor 1-beta;
DE   AltName: Full=LIM/homeobox protein 1.2;
DE            Short=LMX-1.2;
DE   AltName: Full=LIM/homeobox protein LMX1B;
DE   Flags: Fragment;
GN   Name=LMX1B; Synonyms=LMX1.2;
OS   Mesocricetus auratus (Golden hamster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Mesocricetus.
OX   NCBI_TaxID=10036;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Zhang W., Johnson J.D., Rudnick A., German M.S.;
RL   Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor involved in the regulation of podocyte-
CC       expressed genes. Essential for the specification of dorsal limb fate at
CC       both the zeugopodal and autopodal levels.
CC       {ECO:0000250|UniProtKB:O60663}.
CC   -!- SUBUNIT: Interacts with DHX9. {ECO:0000250|UniProtKB:O60663}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
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DR   EMBL; U61141; AAB62320.1; -; mRNA.
DR   AlphaFoldDB; Q60564; -.
DR   SMR; Q60564; -.
DR   STRING; 10036.XP_005082119.1; -.
DR   eggNOG; KOG0490; Eukaryota.
DR   Proteomes; UP000189706; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0048731; P:system development; IEA:UniProt.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR001781; Znf_LIM.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF00412; LIM; 2.
DR   SMART; SM00389; HOX; 1.
DR   SMART; SM00132; LIM; 2.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR   PROSITE; PS50023; LIM_DOMAIN_2; 2.
PE   2: Evidence at transcript level;
KW   Activator; Developmental protein; DNA-binding; Homeobox; LIM domain;
KW   Metal-binding; Nucleus; Reference proteome; Repeat; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           <1..369
FT                   /note="LIM homeobox transcription factor 1-beta"
FT                   /id="PRO_0000075829"
FT   DOMAIN          23..73
FT                   /note="LIM zinc-binding 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DOMAIN          82..135
FT                   /note="LIM zinc-binding 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DNA_BIND        186..245
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          143..196
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
SQ   SEQUENCE   369 AA;  41161 MW;  7C054910561C5054 CRC64;
     PLRPGPATLG VLLGSDCPHP AVCEGCQRPI SDRFLMRVNE SSWHEECLQC AACQQALTTS
     CYFRDRKLYC KQDYQQLFAA KCSGCMEKIA PTEFVMRALE CVYHLGCFCC CVCERQLRKG
     DEFVLKEGQL LCKGDYEKEK DLLSSVSPDE SDSVKSEDED GDMKPAKGQG SQSKGGGDDG
     KDPRRPKRPR TILTTQQRRA FKASFEVSSK PCRKVRETLA AETGLSVRVV QVWFQNQRAK
     MKKLARRHQQ QQEQQNSQRL GQEVLSSRME GMMASYTPLA PPQQQIVAME QSPCGSSDPF
     QQGLTPPQMP GDHMNPYGND SIFHDIDSDT SLTSLSDCFL GSSDVGSLQA RVGNPIDRLY
     SMQSSYFAS