LMX1B_MOUSE
ID LMX1B_MOUSE Reviewed; 395 AA.
AC O88609; Q0VEN6;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2013, sequence version 3.
DT 25-MAY-2022, entry version 172.
DE RecName: Full=LIM homeobox transcription factor 1-beta;
DE AltName: Full=LIM/homeobox protein 1.2;
DE Short=LMX-1.2;
DE AltName: Full=LIM/homeobox protein LMX1B;
GN Name=Lmx1b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 24-395.
RX PubMed=9590288; DOI=10.1038/ng0598-51;
RA Chen H., Lun Y., Ovchinnikov D., Kokubo H., Oberg K.C., Pepicelli C.V.,
RA Gan L., Lee B., Johnson R.L.;
RT "Limb and kidney defects in Lmx1b mutant mice suggest an involvement of
RT LMX1B in human nail patella syndrome.";
RL Nat. Genet. 19:51-55(1998).
CC -!- FUNCTION: Transcription factor involved in the regulation of podocyte-
CC expressed genes. Essential for the specification of dorsal limb fate at
CC both the zeugopodal and autopodal levels.
CC {ECO:0000250|UniProtKB:O60663}.
CC -!- SUBUNIT: Interacts with DHX9. {ECO:0000250|UniProtKB:O60663}.
CC -!- INTERACTION:
CC O88609; Q8R326: Pspc1; NbExp=3; IntAct=EBI-13951208, EBI-309927;
CC O88609; Q8VIJ6: Sfpq; NbExp=5; IntAct=EBI-13951208, EBI-6094576;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC27793.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAI19170.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAI25470.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=CAM26554.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=EDL08602.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AL929212; CAM26554.1; ALT_INIT; Genomic_DNA.
DR EMBL; CH466542; EDL08602.1; ALT_INIT; Genomic_DNA.
DR EMBL; BC119169; AAI19170.1; ALT_INIT; mRNA.
DR EMBL; BC125469; AAI25470.1; ALT_INIT; mRNA.
DR EMBL; AF078166; AAC27793.1; ALT_INIT; mRNA.
DR RefSeq; NP_034855.2; NM_010725.2.
DR AlphaFoldDB; O88609; -.
DR SMR; O88609; -.
DR BioGRID; 201183; 7.
DR IntAct; O88609; 26.
DR STRING; 10090.ENSMUSP00000043616; -.
DR PhosphoSitePlus; O88609; -.
DR PaxDb; O88609; -.
DR PRIDE; O88609; -.
DR ProteomicsDB; 290050; -.
DR DNASU; 16917; -.
DR GeneID; 16917; -.
DR KEGG; mmu:16917; -.
DR UCSC; uc008jhy.2; mouse.
DR CTD; 4010; -.
DR MGI; MGI:1100513; Lmx1b.
DR eggNOG; KOG0490; Eukaryota.
DR InParanoid; O88609; -.
DR OrthoDB; 737134at2759; -.
DR TreeFam; TF315442; -.
DR BioGRID-ORCS; 16917; 2 hits in 74 CRISPR screens.
DR PRO; PR:O88609; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; O88609; protein.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IC:NTNU_SB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISO:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IDA:BHF-UCL.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IDA:ParkinsonsUK-UCL.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0043010; P:camera-type eye development; IMP:MGI.
DR GO; GO:0008283; P:cell population proliferation; IMP:MGI.
DR GO; GO:0021954; P:central nervous system neuron development; IMP:MGI.
DR GO; GO:0021587; P:cerebellum morphogenesis; IMP:MGI.
DR GO; GO:0030199; P:collagen fibril organization; IMP:MGI.
DR GO; GO:0071542; P:dopaminergic neuron differentiation; IMP:MGI.
DR GO; GO:0009953; P:dorsal/ventral pattern formation; IEP:UniProtKB.
DR GO; GO:0030326; P:embryonic limb morphogenesis; NAS:UniProtKB.
DR GO; GO:0035108; P:limb morphogenesis; IMP:MGI.
DR GO; GO:0007626; P:locomotory behavior; IGI:ParkinsonsUK-UCL.
DR GO; GO:0007613; P:memory; IGI:ParkinsonsUK-UCL.
DR GO; GO:0030901; P:midbrain development; IMP:MGI.
DR GO; GO:0030182; P:neuron differentiation; IMP:MGI.
DR GO; GO:0001764; P:neuron migration; IMP:MGI.
DR GO; GO:0042048; P:olfactory behavior; IGI:ParkinsonsUK-UCL.
DR GO; GO:0035265; P:organ growth; IMP:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:ParkinsonsUK-UCL.
DR GO; GO:0010506; P:regulation of autophagy; IMP:ParkinsonsUK-UCL.
DR GO; GO:0010468; P:regulation of gene expression; IMP:MGI.
DR GO; GO:0032386; P:regulation of intracellular transport; IMP:ParkinsonsUK-UCL.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IDA:MGI.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; ISO:MGI.
DR GO; GO:0050808; P:synapse organization; IGI:ParkinsonsUK-UCL.
DR GO; GO:0002930; P:trabecular meshwork development; IMP:MGI.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR001781; Znf_LIM.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF00412; LIM; 2.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00132; LIM; 2.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR PROSITE; PS50023; LIM_DOMAIN_2; 2.
PE 1: Evidence at protein level;
KW Activator; Developmental protein; DNA-binding; Homeobox; LIM domain;
KW Metal-binding; Nucleus; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Zinc.
FT CHAIN 1..395
FT /note="LIM homeobox transcription factor 1-beta"
FT /id="PRO_0000075830"
FT DOMAIN 56..106
FT /note="LIM zinc-binding 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DOMAIN 115..168
FT /note="LIM zinc-binding 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DNA_BIND 219..278
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 176..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 311
FT /note="P -> A (in Ref. 4; AAC27793)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 395 AA; 44102 MW; 9FFBF8A68E7AC676 CRC64;
MDIATGPESL ERCFPRGQTD CAKMLDGIKM EEHALRPGPA TLGVLLGSDC PHPAVCEGCQ
RPISDRFLMR VNESSWHEEC LQCAACQQAL TTSCYFRDRK LYCKQDYQQL FAAKCSGCME
KIAPTEFVMR ALECVYHLGC FCCCVCERQL RKGDEFVLKE GQLLCKGDYE KEKDLLSSVS
PDESDSVKSE DEDGDMKPAK GQGSQSKGSG DDGKDPRRPK RPRTILTTQQ RRAFKASFEV
SSKPCRKVRE TLAAETGLSV RVVQVWFQNQ RAKMKKLARR HQQQQEQQNS QRLGQEVLSS
RMEGMMASYT PLAPPQQQIV AMEQSPYGSS DPFQQGLTPP QMPGNDSIFH DIDSDTSLTS
LSDCFLGSSD VGSLQARVGN PIDRLYSMQS SYFAS
