LMX1B_XENLA
ID LMX1B_XENLA Reviewed; 400 AA.
AC Q8UVR3;
DT 05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=LIM homeobox transcription factor 1-beta.1;
DE AltName: Full=LIM homeobox protein 1b {ECO:0000312|EMBL:AAL32444.1};
DE Short=Xlmx1b {ECO:0000303|PubMed:12755330, ECO:0000303|PubMed:18687324, ECO:0000303|PubMed:20670838};
GN Name=lmx1b.1 {ECO:0000312|Xenbase:XB-GENE-494754};
GN Synonyms=lmx1b {ECO:0000312|EMBL:AAL32444.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAL32444.1}
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND
RP INDUCTION.
RC TISSUE=Neurula {ECO:0000269|PubMed:12755330};
RX PubMed=12755330;
RA Haldin C.E., Nijjar S., Masse K., Barnett M.W., Jones E.A.;
RT "Isolation and growth factor inducibility of the Xenopus laevis Lmx1b
RT gene.";
RL Int. J. Dev. Biol. 47:253-262(2003).
RN [2] {ECO:0000305}
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=18687324; DOI=10.1016/j.ydbio.2008.07.012;
RA Haldin C.E., Masse K.L., Bhamra S., Simrick S., Kyuno J., Jones E.A.;
RT "The lmx1b gene is pivotal in glomus development in Xenopus laevis.";
RL Dev. Biol. 322:74-85(2008).
RN [3] {ECO:0000305}
RP FUNCTION, AND INDUCTION.
RX PubMed=20670838; DOI=10.1016/j.neuron.2010.06.006;
RA Demarque M., Spitzer N.C.;
RT "Activity-dependent expression of Lmx1b regulates specification of
RT serotonergic neurons modulating swimming behavior.";
RL Neuron 67:321-334(2010).
CC -!- FUNCTION: Required for early specification of the kidney glomus, lying
CC upstream of wt1 in the pathway controlling glomus differentiation. The
CC balance in levels and expression patterns of binding partners such as
CC lhx1/lim-1 influences differentiation into glomus or tubule
CC derivatives. Involved in specification of serotonergic neurons.
CC {ECO:0000269|PubMed:18687324, ECO:0000269|PubMed:20670838}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- TISSUE SPECIFICITY: Shows a temporal expression pattern in three main
CC areas: neural, kidney and limbs. From stage 13 onwards, expressed in
CC regions of the nervous system including the placodes and otic vesicles,
CC eye, specific sets of neurons, and in discreet regions of the neural
CC tube. From stage 13, also expressed in the presumptive pronephros, and
CC from stage 27 expression is predominant in the capsule of the
CC pronephric glomus. Also expressed in the developing forelimbs and
CC hindlimbs. In metamorphosing tadpoles, expressed in the eye, brain,
CC muscle and mesonephric kidney. {ECO:0000269|PubMed:12755330,
CC ECO:0000269|PubMed:18687324}.
CC -!- DEVELOPMENTAL STAGE: Expressed zygotically from stage 10.5. Expression
CC is elevated between stages 12.5 and 14, and continues throughout
CC neurulae, tailbud and swimming tadpole stages.
CC {ECO:0000269|PubMed:12755330}.
CC -!- INDUCTION: By activin; retinoic acid (RA) inhibits this up-regulation.
CC Expression in neurons is regulated by calcium (Ca2+) activity: the
CC lower the activity, the larger the number of neurons showing
CC expression. {ECO:0000269|PubMed:12755330, ECO:0000269|PubMed:20670838}.
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DR EMBL; AF414086; AAL32444.1; -; mRNA.
DR RefSeq; NP_001083902.1; NM_001090433.2.
DR AlphaFoldDB; Q8UVR3; -.
DR SMR; Q8UVR3; -.
DR GeneID; 399182; -.
DR KEGG; xla:399182; -.
DR CTD; 399182; -.
DR Xenbase; XB-GENE-494754; lmx1b.1.S.
DR OMA; FQXNDSI; -.
DR OrthoDB; 737134at2759; -.
DR Proteomes; UP000186698; Chromosome 8S.
DR Bgee; 399182; Expressed in internal ear and 11 other tissues.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0072013; P:glomus development; IMP:UniProtKB.
DR GO; GO:0030182; P:neuron differentiation; IMP:UniProtKB.
DR GO; GO:0039020; P:pronephric nephron tubule development; IMP:UniProtKB.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR001781; Znf_LIM.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF00412; LIM; 2.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00132; LIM; 2.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR PROSITE; PS50023; LIM_DOMAIN_2; 2.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; DNA-binding; Homeobox; LIM domain;
KW Metal-binding; Neurogenesis; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc.
FT CHAIN 1..400
FT /note="LIM homeobox transcription factor 1-beta.1"
FT /id="PRO_0000399037"
FT DOMAIN 54..113
FT /note="LIM zinc-binding 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DOMAIN 114..175
FT /note="LIM zinc-binding 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DNA_BIND 218..277
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 175..228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 190..221
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 400 AA; 45106 MW; 8F8AB0CC0E455EF9 CRC64;
MDIATGPESL DRCFTRGPSD CAKMLDTIKM EDHPLRTGTA TLGVLLGSEC QHQAVCEGCQ
RPISDRFLMR VNEASWHEEC LQCTVCQQPL TTSCYFRDRK LFCKQDYQQL FAAKCSGCME
KIAPTEFVMR ALECVYHLSC FCCCVCERQL RKGDEFVLKE GQLLCKSDYE KEKDLLSSGS
PDDSDSVKSD DEEGDVKPGK GRVNQGKGSD DGKDPRRPKR PRTILTTQQR RAFKASFEVS
SKPCRKVRET LAAETGLSVR VVQVWFQNQR AKIKKLARRH QQQQEQQNSQ RLGQEVMSSR
MEGMMTSYAP LAPSQQQIVT MDQNSYSTDP FQQGLTPPQM PGDHMNPYGN DTIFHDIDSD
TSLTSLSDCF LASSEVTSMQ ARVGNPIDRL YSMQSSYFAS
