ID   LNGP_ACULO              Reviewed;          18 AA.
AC   C0HJF8;
DT   22-JAN-2014, integrated into UniProtKB/Swiss-Prot.
DT   22-JAN-2014, sequence version 1.
DT   25-MAY-2022, entry version 12.
DE   RecName: Full=Longipin {ECO:0000303|PubMed:27997568};
OS   Acutisoma longipes (Neotropical harvestman) (Goniosoma longipes).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Opiliones; Laniatores; Gonyleptoidea; Gonyleptidae; Acutisoma.
OX   NCBI_TaxID=863974 {ECO:0000303|PubMed:27997568};
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, INDUCTION, MASS
RP   SPECTROMETRY, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC   TISSUE=Hemolymph {ECO:0000303|PubMed:27997568};
RX   PubMed=27997568; DOI=10.1371/journal.pone.0167953;
RA   Sayegh R.S., Batista I.F., Melo R.L., Riske K.A., Daffre S., Montich G.,
RA   da Silva Junior P.I.;
RT   "Longipin: An Amyloid Antimicrobial Peptide from the Harvestman Acutisoma
RT   longipes (Arachnida: Opiliones) with Preferential Affinity for Anionic
RT   Vesicles.";
RL   PLoS ONE 11:E0167953-E0167953(2016).
CC   -!- FUNCTION: Has antifungal activity against yeasts like C.albicans MDM8
CC       (MIC=15-30 uM), C.albicans IOC 4558 (MIC=7.5-15 uM), C.tropicalis IOC
CC       4560 (MIC=3.8-7.5 uM) and C.guilliermondii IOC 4557 (MIC=3.8-7.5 uM)
CC       but not against filamentous fungi like A.niger, C.herbarum ATCC26362 or
CC       P.farinosus IBC251. Has weak activity against the Gram-positive
CC       bacterium M.luteus A270 (MIC=60-120 uM) and against Gram-negative
CC       bacteria P.aeruginosa ATCC27853 (MIC=60-120 uM) and S.marcescens
CC       ATCC4112 (MIC=60-120 uM). Not active against S.aureus ATCC 29213 and
CC       S.epidermidis ATCC 12228, M.luteus BR2, E.coli D31, E.coli SBS363 or
CC       E.cloacae beta12. Probably acts by disrupting target cell membranes.
CC       {ECO:0000269|PubMed:27997568}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:27997568}. Target
CC       cell membrane {ECO:0000303|PubMed:27997568}.
CC   -!- INDUCTION: Constitutively expressed. {ECO:0000269|PubMed:27997568}.
CC   -!- MASS SPECTROMETRY: Mass=2124.9; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:27997568};
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DR   AlphaFoldDB; C0HJF8; -.
DR   GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0050832; P:defense response to fungus; IDA:UniProtKB.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IDA:UniProtKB.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IDA:UniProtKB.
DR   GO; GO:0044364; P:disruption of cells of another organism; IDA:UniProtKB.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Direct protein sequencing; Fungicide; Membrane;
KW   Secreted; Target cell membrane; Target membrane.
FT   PEPTIDE         1..18
FT                   /note="Longipin"
FT                   /evidence="ECO:0000269|PubMed:27997568"
FT                   /id="PRO_0000425148"
SQ   SEQUENCE   18 AA;  2126 MW;  3E57BDE183F51D19 CRC64;
     SGYLPGKEYV YKYKGKVF