LNK4_ARATH
ID LNK4_ARATH Reviewed; 274 AA.
AC Q9FL48; F4K5B1; F4K5B3; F4K5B4; Q94B51;
DT 13-APR-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Protein LNK4 {ECO:0000303|PubMed:23818596};
DE AltName: Full=Night light-inducible and clock-regulated 4 {ECO:0000303|PubMed:23818596};
GN Name=LNK4 {ECO:0000303|PubMed:23818596};
GN OrderedLocusNames=At5g06980 {ECO:0000312|Araport:AT5G06980};
GN ORFNames=MOJ9.15 {ECO:0000312|EMBL:BAB11156.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9679202; DOI=10.1093/dnares/5.2.131;
RA Kaneko T., Kotani H., Nakamura Y., Sato S., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence
RT features of the regions of 1,381,565 bp covered by twenty one physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:131-145(1998).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP INDUCTION, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=23818596; DOI=10.1073/pnas.1302170110;
RA Rugnone M.L., Faigon Soverna A., Sanchez S.E., Schlaen R.G., Hernando C.E.,
RA Seymour D.K., Mancini E., Chernomoretz A., Weigel D., Mas P.,
RA Yanovsky M.J.;
RT "LNK genes integrate light and clock signaling networks at the core of the
RT Arabidopsis oscillator.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:12120-12125(2013).
RN [5]
RP DISRUPTION PHENOTYPE.
RX PubMed=25012192; DOI=10.1105/tpc.114.126573;
RA Xie Q., Wang P., Liu X., Yuan L., Wang L., Zhang C., Li Y., Xing H.,
RA Zhi L., Yue Z., Zhao C., McClung C.R., Xu X.;
RT "LNK1 and LNK2 are transcriptional coactivators in the Arabidopsis
RT circadian oscillator.";
RL Plant Cell 26:2843-2857(2014).
RN [6]
RP INTERACTION WITH RVE8.
RX PubMed=25848001; DOI=10.1073/pnas.1420792112;
RA Perez-Garcia P., Ma Y., Yanovsky M.J., Mas P.;
RT "Time-dependent sequestration of RVE8 by LNK proteins shapes the diurnal
RT oscillation of anthocyanin biosynthesis.";
RL Proc. Natl. Acad. Sci. U.S.A. 112:5249-5253(2015).
CC -!- FUNCTION: Probable transcriptional coactivator.
CC {ECO:0000250|UniProtKB:A8MQN2}.
CC -!- SUBUNIT: Interacts with REV8. {ECO:0000269|PubMed:25848001}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q9FL48-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9FL48-2; Sequence=VSP_058223;
CC Name=3;
CC IsoId=Q9FL48-3; Sequence=VSP_058222;
CC Name=4;
CC IsoId=Q9FL48-4; Sequence=VSP_058221, VSP_058224;
CC -!- INDUCTION: Repressed by members of the TOC1/PRR1 family of clock genes.
CC {ECO:0000269|PubMed:23818596}.
CC -!- DISRUPTION PHENOTYPE: No effect on circadian clock.
CC {ECO:0000269|PubMed:25012192}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK68789.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB010697; BAB11156.1; -; Genomic_DNA.
DR EMBL; CP002688; AED91092.1; -; Genomic_DNA.
DR EMBL; CP002688; AED91093.1; -; Genomic_DNA.
DR EMBL; CP002688; AED91094.1; -; Genomic_DNA.
DR EMBL; CP002688; AED91095.1; -; Genomic_DNA.
DR EMBL; CP002688; ANM68815.1; -; Genomic_DNA.
DR EMBL; AY063858; AAL36214.1; -; mRNA.
DR EMBL; AY091310; AAM14249.1; -; mRNA.
DR EMBL; AY042849; AAK68789.1; ALT_INIT; mRNA.
DR EMBL; AY072472; AAL66887.1; -; mRNA.
DR RefSeq; NP_001190245.1; NM_001203316.1. [Q9FL48-4]
DR RefSeq; NP_001190246.1; NM_001203317.1. [Q9FL48-3]
DR RefSeq; NP_001330537.1; NM_001342915.1. [Q9FL48-2]
DR RefSeq; NP_568176.1; NM_120780.4. [Q9FL48-2]
DR RefSeq; NP_850785.1; NM_180454.2. [Q9FL48-1]
DR AlphaFoldDB; Q9FL48; -.
DR STRING; 3702.AT5G06980.4; -.
DR PRIDE; Q9FL48; -.
DR ProteomicsDB; 238629; -. [Q9FL48-1]
DR EnsemblPlants; AT5G06980.1; AT5G06980.1; AT5G06980. [Q9FL48-2]
DR EnsemblPlants; AT5G06980.2; AT5G06980.2; AT5G06980. [Q9FL48-1]
DR EnsemblPlants; AT5G06980.3; AT5G06980.3; AT5G06980. [Q9FL48-3]
DR EnsemblPlants; AT5G06980.4; AT5G06980.4; AT5G06980. [Q9FL48-4]
DR EnsemblPlants; AT5G06980.5; AT5G06980.5; AT5G06980. [Q9FL48-2]
DR GeneID; 830589; -.
DR Gramene; AT5G06980.1; AT5G06980.1; AT5G06980. [Q9FL48-2]
DR Gramene; AT5G06980.2; AT5G06980.2; AT5G06980. [Q9FL48-1]
DR Gramene; AT5G06980.3; AT5G06980.3; AT5G06980. [Q9FL48-3]
DR Gramene; AT5G06980.4; AT5G06980.4; AT5G06980. [Q9FL48-4]
DR Gramene; AT5G06980.5; AT5G06980.5; AT5G06980. [Q9FL48-2]
DR KEGG; ath:AT5G06980; -.
DR Araport; AT5G06980; -.
DR TAIR; locus:2169439; AT5G06980.
DR OMA; WESHQEV; -.
DR OrthoDB; 1619664at2759; -.
DR PhylomeDB; Q9FL48; -.
DR PRO; PR:Q9FL48; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FL48; baseline and differential.
DR GO; GO:0007623; P:circadian rhythm; IEA:InterPro.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR InterPro; IPR039928; LNK.
DR PANTHER; PTHR33334; PTHR33334; 1.
PE 1: Evidence at protein level;
KW Activator; Alternative splicing; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..274
FT /note="Protein LNK4"
FT /id="PRO_0000436034"
FT REGION 209..249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 217..237
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 104..105
FT /note="LS -> F (in isoform 4)"
FT /id="VSP_058221"
FT VAR_SEQ 213..274
FT /note="KSDSNSDEFLEDRTRETEFETKLNRQSRGQSHIQQDGIQHEKYASTEETFFC
FT SRIREFHHIW -> NSNDSSPSMTFLSVGKLNLKPNSIDRAVANLTFNKMESNMRNMPP
FT PKRLSSVQG (in isoform 3)"
FT /id="VSP_058222"
FT VAR_SEQ 226
FT /note="T -> TS (in isoform 2)"
FT /id="VSP_058223"
FT VAR_SEQ 227..274
FT /note="RETEFETKLNRQSRGQSHIQQDGIQHEKYASTEETFFCSRIREFHHIW ->
FT SSNDSSPSMTFLSVGKLNLKPNSIDRAVANLTFNKMESNMRNMPPPKRLSSVQG (in
FT isoform 4)"
FT /id="VSP_058224"
SQ SEQUENCE 274 AA; 32040 MW; 721485AA853B2CFF CRC64;
MDRYSRRNLE DLVVPNYQET SDSYPSPDMW GTGWSMNSSE AAEKCFDYDV IHNGFSGGLY
SQMEMDMGTS EQVEEETKKL KASGCFDRSL HDFDEIQHMD DMFLSSILED VPGNENFLSF
KESDNNNSSS SSYLDTTDGR EVPLFHYNWE TCQDMPLMEE DAPMNLCEEN KEEASAEEVV
LQDLQRATEM LTDDTRKCFR DTFYRLAKNS QQKSDSNSDE FLEDRTRETE FETKLNRQSR
GQSHIQQDGI QHEKYASTEE TFFCSRIREF HHIW
