ID   LNP1_HUMAN              Reviewed;         178 AA.
AC   A1A4G5; B7ZLT3;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Leukemia NUP98 fusion partner 1;
GN   Name=LNP1; Synonyms=NP3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   CHROMOSOMAL TRANSLOCATION WITH NUP98.
RX   PubMed=16467868; DOI=10.1038/sj.leu.2404130;
RA   Romana S.P., Radford-Weiss I., Ben Abdelali R., Schluth C., Petit A.,
RA   Dastugue N., Talmant P., Bilhou-Nabera C., Mugneret F.,
RA   Lafage-Pochitaloff M., Mozziconacci M.-J., Andrieu J., Lai J.-L., Terre C.,
RA   Rack K., Cornillet-Lefebvre P., Luquet I., Nadal N., Nguyen-Khac F.,
RA   Perot C., Van den Akker J., Fert-Ferrer S., Cabrol C., Charrin C.,
RA   Tigaud I., Poirel H., Vekemans M., Bernard O.A., Berger R.;
RT   "NUP98 rearrangements in hematopoietic malignancies: a study of the Groupe
RT   Francophone de Cytogenetique Hematologique.";
RL   Leukemia 20:696-706(2006).
CC   -!- DISEASE: Note=A chromosomal aberration involving LNP1 is found in a
CC       form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation
CC       t(3;11)(q12.2;p15.4) with NUP98. {ECO:0000269|PubMed:16467868}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC126362; AAI26363.1; -; mRNA.
DR   EMBL; BC130480; AAI30481.1; -; mRNA.
DR   EMBL; BC144031; AAI44032.1; -; mRNA.
DR   CCDS; CCDS43120.1; -.
DR   RefSeq; NP_001078920.1; NM_001085451.1.
DR   AlphaFoldDB; A1A4G5; -.
DR   BioGRID; 131532; 26.
DR   IntAct; A1A4G5; 1.
DR   STRING; 9606.ENSP00000373191; -.
DR   iPTMnet; A1A4G5; -.
DR   PhosphoSitePlus; A1A4G5; -.
DR   BioMuta; LNP1; -.
DR   jPOST; A1A4G5; -.
DR   MassIVE; A1A4G5; -.
DR   MaxQB; A1A4G5; -.
DR   PaxDb; A1A4G5; -.
DR   PeptideAtlas; A1A4G5; -.
DR   PRIDE; A1A4G5; -.
DR   ProteomicsDB; 91; -.
DR   Antibodypedia; 46510; 22 antibodies from 12 providers.
DR   DNASU; 348801; -.
DR   Ensembl; ENST00000383693.8; ENSP00000373191.3; ENSG00000206535.8.
DR   GeneID; 348801; -.
DR   KEGG; hsa:348801; -.
DR   MANE-Select; ENST00000383693.8; ENSP00000373191.3; NM_001085451.2; NP_001078920.1.
DR   UCSC; uc003dtx.5; human.
DR   CTD; 348801; -.
DR   GeneCards; LNP1; -.
DR   HGNC; HGNC:28014; LNP1.
DR   HPA; ENSG00000206535; Group enriched (retina, testis).
DR   neXtProt; NX_A1A4G5; -.
DR   OpenTargets; ENSG00000206535; -.
DR   PharmGKB; PA142671542; -.
DR   VEuPathDB; HostDB:ENSG00000206535; -.
DR   eggNOG; ENOG502S2J6; Eukaryota.
DR   GeneTree; ENSGT00390000007797; -.
DR   HOGENOM; CLU_119588_0_0_1; -.
DR   InParanoid; A1A4G5; -.
DR   OMA; FEKQLHF; -.
DR   OrthoDB; 1320740at2759; -.
DR   PhylomeDB; A1A4G5; -.
DR   TreeFam; TF342726; -.
DR   PathwayCommons; A1A4G5; -.
DR   SignaLink; A1A4G5; -.
DR   BioGRID-ORCS; 348801; 10 hits in 1070 CRISPR screens.
DR   GenomeRNAi; 348801; -.
DR   Pharos; A1A4G5; Tdark.
DR   PRO; PR:A1A4G5; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   RNAct; A1A4G5; protein.
DR   Bgee; ENSG00000206535; Expressed in cardiac muscle of right atrium and 163 other tissues.
DR   ExpressionAtlas; A1A4G5; baseline and differential.
DR   Genevisible; A1A4G5; HS.
DR   InterPro; IPR029280; LNP1.
DR   PANTHER; PTHR35667; PTHR35667; 1.
DR   Pfam; PF15419; LNP1; 1.
PE   2: Evidence at transcript level;
KW   Chromosomal rearrangement; Reference proteome.
FT   CHAIN           1..178
FT                   /note="Leukemia NUP98 fusion partner 1"
FT                   /id="PRO_0000341357"
FT   REGION          28..55
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          89..108
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          147..178
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        147..171
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   178 AA;  21321 MW;  A51126C819511E23 CRC64;
     MEHKDDDDDD VSFAKWMSSF WGHSWREEDQ RGLRERHRLQ ATSHRKTSLP CPLPVLPRIP
     SSDCHPRRHS HEDQEFRCRS HVRDYRKYSE DGSFKEPLES KGRSHSKIEK FSESFERQLC
     FRTKRSASLG PESRKERNER ECLRMEIKSR KKVEEERSSR KEEHGEAHMA PLFEKGPE