ID   LNTA_LISMO              Reviewed;         205 AA.
AC   Q8Y9T5;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Listeria nuclear targeted protein A;
DE   Flags: Precursor;
GN   Name=lntA; OrderedLocusNames=lmo0438;
OS   Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria.
OX   NCBI_TaxID=169963;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-679 / EGD-e;
RX   PubMed=11679669; DOI=10.1126/science.1063447;
RA   Glaser P., Frangeul L., Buchrieser C., Rusniok C., Amend A., Baquero F.,
RA   Berche P., Bloecker H., Brandt P., Chakraborty T., Charbit A.,
RA   Chetouani F., Couve E., de Daruvar A., Dehoux P., Domann E.,
RA   Dominguez-Bernal G., Duchaud E., Durant L., Dussurget O., Entian K.-D.,
RA   Fsihi H., Garcia-del Portillo F., Garrido P., Gautier L., Goebel W.,
RA   Gomez-Lopez N., Hain T., Hauf J., Jackson D., Jones L.-M., Kaerst U.,
RA   Kreft J., Kuhn M., Kunst F., Kurapkat G., Madueno E., Maitournam A.,
RA   Mata Vicente J., Ng E., Nedjari H., Nordsiek G., Novella S., de Pablos B.,
RA   Perez-Diaz J.-C., Purcell R., Remmel B., Rose M., Schlueter T., Simoes N.,
RA   Tierrez A., Vazquez-Boland J.-A., Voss H., Wehland J., Cossart P.;
RT   "Comparative genomics of Listeria species.";
RL   Science 294:849-852(2001).
RN   [2]
RP   X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 34-205, FUNCTION, INTERACTION WITH
RP   BAHD1, SUBCELLULAR LOCATION, INDUCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=21252314; DOI=10.1126/science.1200120;
RA   Lebreton A., Lakisic G., Job V., Fritsch L., Tham T.N., Camejo A.,
RA   Mattei P.J., Regnault B., Nahori M.A., Cabanes D., Gautreau A.,
RA   Ait-Si-Ali S., Dessen A., Cossart P., Bierne H.;
RT   "A bacterial protein targets the BAHD1 chromatin complex to stimulate type
RT   III interferon response.";
RL   Science 331:1319-1321(2011).
CC   -!- FUNCTION: Relieves the repression of host cell immune response genes
CC       (interferon-stimulated genes) by blocking the recruitment of host BAHD1
CC       to these genes. May modulate interferon-mediated immune response to
CC       control bacterial colonization of the host.
CC       {ECO:0000269|PubMed:21252314}.
CC   -!- SUBUNIT: Interacts specifically with host BAHD1.
CC       {ECO:0000269|PubMed:21252314}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:21252314}. Host
CC       nucleus {ECO:0000269|PubMed:21252314}.
CC   -!- INDUCTION: Induced in infected host cells. Expression is regulated by
CC       PrfA and sigma-B factor (SigB). {ECO:0000269|PubMed:21252314}.
CC   -!- DISRUPTION PHENOTYPE: Deletion of lntA leads to a decrease in bacterial
CC       colonization of spleens and livers, as well as blood bacteraemia.
CC       {ECO:0000269|PubMed:21252314}.
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DR   EMBL; AL591975; CAC98517.1; -; Genomic_DNA.
DR   PIR; AG1129; AG1129.
DR   RefSeq; NP_463967.1; NC_003210.1.
DR   RefSeq; WP_010989465.1; NZ_CP023861.1.
DR   PDB; 2XL4; X-ray; 2.30 A; A=34-205.
DR   PDB; 4CIH; X-ray; 2.22 A; A/B/C/D=56-205.
DR   PDBsum; 2XL4; -.
DR   PDBsum; 4CIH; -.
DR   AlphaFoldDB; Q8Y9T5; -.
DR   SMR; Q8Y9T5; -.
DR   STRING; 169963.lmo0438; -.
DR   PaxDb; Q8Y9T5; -.
DR   PRIDE; Q8Y9T5; -.
DR   EnsemblBacteria; CAC98517; CAC98517; CAC98517.
DR   GeneID; 985161; -.
DR   KEGG; lmo:lmo0438; -.
DR   HOGENOM; CLU_1336149_0_0_9; -.
DR   OMA; IKEESWS; -.
DR   EvolutionaryTrace; Q8Y9T5; -.
DR   Proteomes; UP000000817; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IDA:CACAO.
DR   GO; GO:0042025; C:host cell nucleus; IDA:CACAO.
DR   Gene3D; 1.20.120.1420; -; 1.
DR   InterPro; IPR043113; LntA_helix.
PE   1: Evidence at protein level;
KW   3D-structure; Host nucleus; Reference proteome; Secreted; Signal;
KW   Virulence.
FT   SIGNAL          1..36
FT                   /evidence="ECO:0000255"
FT   CHAIN           37..205
FT                   /note="Listeria nuclear targeted protein A"
FT                   /id="PRO_0000409775"
FT   HELIX           63..89
FT                   /evidence="ECO:0007829|PDB:4CIH"
FT   HELIX           97..118
FT                   /evidence="ECO:0007829|PDB:4CIH"
FT   HELIX           122..125
FT                   /evidence="ECO:0007829|PDB:4CIH"
FT   HELIX           127..129
FT                   /evidence="ECO:0007829|PDB:4CIH"
FT   HELIX           132..158
FT                   /evidence="ECO:0007829|PDB:4CIH"
FT   TURN            159..161
FT                   /evidence="ECO:0007829|PDB:4CIH"
FT   HELIX           164..172
FT                   /evidence="ECO:0007829|PDB:4CIH"
FT   STRAND          173..175
FT                   /evidence="ECO:0007829|PDB:2XL4"
FT   HELIX           176..194
FT                   /evidence="ECO:0007829|PDB:4CIH"
SQ   SEQUENCE   205 AA;  23384 MW;  947E25DBA92A1F09 CRC64;
     MKKLVAWFNG LSKMWKVVVI IGAVFVVIIA LTTGEDEGEQ TKTKKDSNKV VKTASRPKLS
     TKDLALIKAD LAEFEARELS SEKILKDTIK EESWSDLDFA NDNINQMIGT MKRYQQEILS
     IDAIKRSSEA SADTEAFKKI FKEWSEFKIE RIQVTIDLLN GKKDSEAVFK KTYPNQIIFK
     KVRTNKLQTA LNNLKVGYEL LDSQK