LOB_ARATH
ID LOB_ARATH Reviewed; 186 AA.
AC Q9FML4; B7XG58; Q549W6; Q8VWF4;
DT 17-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Protein LATERAL ORGAN BOUNDARIES;
DE AltName: Full=ASYMMETRIC LEAVES 2-like protein 4;
DE Short=AS2-like protein 4;
GN Name=LOB; Synonyms=ASL4; OrderedLocusNames=At5g63090; ORFNames=MDC12.5;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, GENE FAMILY, AND
RP NOMENCLATURE.
RC STRAIN=cv. Landsberg erecta;
RX PubMed=12068116; DOI=10.1104/pp.010926;
RA Shuai B., Reynaga-Pena C.G., Springer P.S.;
RT "The LATERAL ORGAN BOUNDARIES gene defines a novel, plant-specific gene
RT family.";
RL Plant Physiol. 129:747-761(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, AND NOMENCLATURE.
RX PubMed=12040093; DOI=10.1093/pcp/pcf077;
RA Iwakawa H., Ueno Y., Semiarti E., Onouchi H., Kojima S., Tsukaya H.,
RA Hasebe M., Soma T., Ikezaki M., Machida C., Machida Y.;
RT "The ASYMMETRIC LEAVES2 gene of Arabidopsis thaliana, required for
RT formation of a symmetric flat leaf lamina, encodes a member of a novel
RT family of proteins characterized by cysteine repeats and a leucine
RT zipper.";
RL Plant Cell Physiol. 43:467-478(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=19154202; DOI=10.1111/j.1365-313x.2009.03797.x;
RA Matsumura Y., Iwakawa H., Machida Y., Machida C.;
RT "Characterization of genes in the ASYMMETRIC LEAVES2/LATERAL ORGAN
RT BOUNDARIES (AS2/LOB) family in Arabidopsis thaliana, and functional and
RT molecular comparisons between AS2 and other family members.";
RL Plant J. 58:525-537(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9501997; DOI=10.1093/dnares/4.6.401;
RA Nakamura Y., Sato S., Kaneko T., Kotani H., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. III. Sequence
RT features of the regions of 1,191,918 bp covered by seventeen physically
RT assigned P1 clones.";
RL DNA Res. 4:401-414(1997).
RN [5]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Kim C.J., Chen H., Quinitio C., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP INDUCTION.
RX PubMed=11934861; DOI=10.1242/dev.129.8.1957;
RA Byrne M.E., Simorowski J., Martienssen R.A.;
RT "ASYMMETRIC LEAVES1 reveals knox gene redundancy in Arabidopsis.";
RL Development 129:1957-1965(2002).
CC -!- FUNCTION: Not known; ectopic expression of LOB leads to alterations in
CC the size and shape of leaves and floral organs and causes male and
CC female sterility.
CC -!- INTERACTION:
CC Q9FML4; Q3EAI1-2: BHLH60; NbExp=3; IntAct=EBI-15194891, EBI-15194889;
CC Q9FML4; Q9AT61: LBD13; NbExp=3; IntAct=EBI-15194891, EBI-4432427;
CC Q9FML4; Q9SHE9: LBD4; NbExp=3; IntAct=EBI-15194891, EBI-4445715;
CC Q9FML4; Q8LPR5: TCP4; NbExp=3; IntAct=EBI-15194891, EBI-15192325;
CC -!- TISSUE SPECIFICITY: Expressed in a band of cells at the adaxial base of
CC all lateral organs formed from the shoot apical meristem and at the
CC base of lateral roots. {ECO:0000269|PubMed:12068116}.
CC -!- INDUCTION: Positively regulated within the shoot apex by both
CC ASYMMETRIC LEAVES 1 (AS1) and ASYMMETRIC LEAVES 2 (AS2/LBD6) and by
CC KNAT1. {ECO:0000269|PubMed:11934861}.
CC -!- SIMILARITY: Belongs to the LOB domain-containing protein family.
CC {ECO:0000305}.
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DR EMBL; AF447897; AAL40346.1; -; mRNA.
DR EMBL; AF447898; AAL40347.1; -; mRNA.
DR EMBL; AF447899; AAL40348.1; -; mRNA.
DR EMBL; AF447900; AAL40349.1; -; mRNA.
DR EMBL; AB164305; BAD12424.1; -; mRNA.
DR EMBL; AB473837; BAH10548.1; -; mRNA.
DR EMBL; AB008265; BAB10551.1; -; Genomic_DNA.
DR EMBL; CP002688; AED97700.1; -; Genomic_DNA.
DR EMBL; CP002688; AED97701.1; -; Genomic_DNA.
DR EMBL; CP002688; AED97702.1; -; Genomic_DNA.
DR EMBL; CP002688; AED97703.1; -; Genomic_DNA.
DR EMBL; BT025745; ABF83635.1; -; mRNA.
DR RefSeq; NP_201114.1; NM_125703.4.
DR RefSeq; NP_851252.1; NM_180921.2.
DR RefSeq; NP_851253.1; NM_180922.1.
DR RefSeq; NP_851254.1; NM_180923.1.
DR AlphaFoldDB; Q9FML4; -.
DR SMR; Q9FML4; -.
DR BioGRID; 21672; 17.
DR IntAct; Q9FML4; 12.
DR STRING; 3702.AT5G63090.3; -.
DR PaxDb; Q9FML4; -.
DR PRIDE; Q9FML4; -.
DR ProteomicsDB; 238414; -.
DR EnsemblPlants; AT5G63090.1; AT5G63090.1; AT5G63090.
DR EnsemblPlants; AT5G63090.2; AT5G63090.2; AT5G63090.
DR EnsemblPlants; AT5G63090.3; AT5G63090.3; AT5G63090.
DR EnsemblPlants; AT5G63090.4; AT5G63090.4; AT5G63090.
DR GeneID; 836429; -.
DR Gramene; AT5G63090.1; AT5G63090.1; AT5G63090.
DR Gramene; AT5G63090.2; AT5G63090.2; AT5G63090.
DR Gramene; AT5G63090.3; AT5G63090.3; AT5G63090.
DR Gramene; AT5G63090.4; AT5G63090.4; AT5G63090.
DR KEGG; ath:AT5G63090; -.
DR Araport; AT5G63090; -.
DR TAIR; locus:2161982; AT5G63090.
DR eggNOG; ENOG502RXGG; Eukaryota.
DR HOGENOM; CLU_058353_5_2_1; -.
DR InParanoid; Q9FML4; -.
DR OMA; WHRFLEL; -.
DR OrthoDB; 1257157at2759; -.
DR PhylomeDB; Q9FML4; -.
DR PRO; PR:Q9FML4; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FML4; baseline and differential.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0010199; P:organ boundary specification between lateral organs and the meristem; IMP:TAIR.
DR InterPro; IPR004883; LOB.
DR Pfam; PF03195; LOB; 1.
DR PROSITE; PS50891; LOB; 1.
PE 1: Evidence at protein level;
KW Developmental protein; Reference proteome.
FT CHAIN 1..186
FT /note="Protein LATERAL ORGAN BOUNDARIES"
FT /id="PRO_0000132250"
FT DOMAIN 10..111
FT /note="LOB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00291"
SQ SEQUENCE 186 AA; 20227 MW; 7CF92D7C07502D73 CRC64;
MASSSNSYNS PCAACKFLRR KCMPGCIFAP YFPPEEPHKF ANVHKIFGAS NVTKLLNELL
PHQREDAVNS LAYEAEARVR DPVYGCVGAI SYLQRQVHRL QKELDAANAD LAHYGLSTSA
AGAPGNVVDL VFQPQPLPSQ QLPPLNPVYR LSGASPVMNQ MPRGTGGSYG TFLPWNNGHD
QQGGNM
