ID   LOC1_AJECN              Reviewed;         207 AA.
AC   A6RF09;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 2.
DT   25-MAY-2022, entry version 37.
DE   RecName: Full=60S ribosomal subunit assembly/export protein LOC1;
GN   Name=LOC1; ORFNames=HCAG_08224;
OS   Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS   (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma;
OC   unclassified Histoplasma.
OX   NCBI_TaxID=2059318;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NAm1 / WU24;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
CC   -!- FUNCTION: Required for efficient assembly and nuclear export of the 60S
CC       ribosomal subunit. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the 66S pre-ribosomal particle. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LOC1 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EDN04558.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; CH476664; EDN04558.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_001537115.1; XM_001537065.1.
DR   AlphaFoldDB; A6RF09; -.
DR   SMR; A6RF09; -.
DR   STRING; 339724.A6RF09; -.
DR   EnsemblFungi; EDN04558; EDN04558; HCAG_08224.
DR   GeneID; 5443393; -.
DR   KEGG; aje:HCAG_08224; -.
DR   HOGENOM; CLU_096593_0_0_1; -.
DR   OrthoDB; 1641629at2759; -.
DR   Proteomes; UP000009297; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003729; F:mRNA binding; IEA:InterPro.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   GO; GO:0042273; P:ribosomal large subunit biogenesis; IEA:InterPro.
DR   InterPro; IPR037650; Loc1.
DR   PANTHER; PTHR28028; PTHR28028; 1.
PE   3: Inferred from homology;
KW   Coiled coil; mRNA transport; Nucleus; Reference proteome;
KW   Ribosome biogenesis; Transport.
FT   CHAIN           1..207
FT                   /note="60S ribosomal subunit assembly/export protein LOC1"
FT                   /id="PRO_0000308782"
FT   REGION          1..71
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          133..207
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          120..166
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..39
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        45..71
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        133..175
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   207 AA;  23135 MW;  88A7B24405044C7B CRC64;
     MAPNRGSSSK SSSKPSNKSS SSSKSKSKPL ASSSRVSKPK PKSSIRRPLP KEVKAKPRTA
     PENLKKRKKR IYTEKELDLP QLNMITPVGV TKPKGMKKGK VFVDDQESMM TILAIVNAEK
     EGQIESKMMK ARQMEEIREA RRKEAEARQM AKKEKLEKVK DSLRKKRRPD SGEGKGDGKN
     SSSGEAKEFS SSKTSRSKPN RKRVSFT