ID   LOC1_ASPFU              Reviewed;         190 AA.
AC   Q4WDG1;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=60S ribosomal subunit assembly/export protein loc1;
GN   Name=loc1; ORFNames=AFUA_6G04630;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=330879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA   Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA   Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA   Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA   Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA   Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA   Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA   O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA   Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA   Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA   Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA   Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA   Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- FUNCTION: Required for efficient assembly and nuclear export of the 60S
CC       ribosomal subunit. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the 66S pre-ribosomal particle. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LOC1 family. {ECO:0000305}.
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DR   EMBL; AAHF01000012; EAL85577.1; -; Genomic_DNA.
DR   RefSeq; XP_747615.1; XM_742522.1.
DR   AlphaFoldDB; Q4WDG1; -.
DR   SMR; Q4WDG1; -.
DR   STRING; 746128.CADAFUBP00009104; -.
DR   EnsemblFungi; EAL85577; EAL85577; AFUA_6G04630.
DR   GeneID; 3505215; -.
DR   KEGG; afm:AFUA_6G04630; -.
DR   VEuPathDB; FungiDB:Afu6g04630; -.
DR   eggNOG; ENOG502RY6R; Eukaryota.
DR   HOGENOM; CLU_096593_0_0_1; -.
DR   InParanoid; Q4WDG1; -.
DR   OMA; GQIESRM; -.
DR   OrthoDB; 1641629at2759; -.
DR   Proteomes; UP000002530; Chromosome 6.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IBA:GO_Central.
DR   GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR   GO; GO:0008298; P:intracellular mRNA localization; IBA:GO_Central.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   GO; GO:0042273; P:ribosomal large subunit biogenesis; IBA:GO_Central.
DR   InterPro; IPR037650; Loc1.
DR   PANTHER; PTHR28028; PTHR28028; 1.
PE   3: Inferred from homology;
KW   Coiled coil; mRNA transport; Nucleus; Reference proteome;
KW   Ribosome biogenesis; Transport.
FT   CHAIN           1..190
FT                   /note="60S ribosomal subunit assembly/export protein loc1"
FT                   /id="PRO_0000308785"
FT   REGION          1..69
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          129..190
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          109..165
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        7..26
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        27..41
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        42..67
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        129..166
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        175..190
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   190 AA;  21099 MW;  01ECCFB6BFF8B0E0 CRC64;
     MAPNKPSVKG KSSSKGDSGK SKPLSSASKV SKKHAKRPPP KEVKSKARTE SSLLKKTKKR
     EYTEEELGLP KLNMITPVGV VKPKGKKKGK VFVDDQEGMM TILAMVNAEQ EGHIESKLQK
     ARQLEEIREA KRKEAEARHA EKKNKLEEAK QSIRQKRKRK SSGNEDSKSD ASTSKSSSKS
     KEKRKSVSFA