LOC1_CANAL
ID LOC1_CANAL Reviewed; 206 AA.
AC Q5AJF1; A0A1D8PJD0;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 03-AUG-2022, entry version 73.
DE RecName: Full=60S ribosomal subunit assembly/export protein LOC1;
GN Name=LOC1; OrderedLocusNames=CAALFM_C302040CA;
GN ORFNames=CaO19.1642, CaO19.9209;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC -!- FUNCTION: Required for efficient assembly and nuclear export of the 60S
CC ribosomal subunit. {ECO:0000250}.
CC -!- SUBUNIT: Component of the 66S pre-ribosomal particle. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the LOC1 family. {ECO:0000305}.
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DR EMBL; CP017625; AOW28242.1; -; Genomic_DNA.
DR RefSeq; XP_721719.1; XM_716626.1.
DR AlphaFoldDB; Q5AJF1; -.
DR SMR; Q5AJF1; -.
DR STRING; 237561.Q5AJF1; -.
DR PRIDE; Q5AJF1; -.
DR GeneID; 3636579; -.
DR KEGG; cal:CAALFM_C302040CA; -.
DR CGD; CAL0000180322; orf19.9209.
DR VEuPathDB; FungiDB:C3_02040C_A; -.
DR eggNOG; ENOG502RY6R; Eukaryota.
DR HOGENOM; CLU_096593_1_0_1; -.
DR InParanoid; Q5AJF1; -.
DR OMA; GQIESRM; -.
DR OrthoDB; 1641629at2759; -.
DR PRO; PR:Q5AJF1; -.
DR Proteomes; UP000000559; Chromosome 3.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0008298; P:intracellular mRNA localization; IBA:GO_Central.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR GO; GO:0042273; P:ribosomal large subunit biogenesis; IBA:GO_Central.
DR InterPro; IPR037650; Loc1.
DR PANTHER; PTHR28028; PTHR28028; 1.
PE 3: Inferred from homology;
KW Coiled coil; mRNA transport; Nucleus; Reference proteome;
KW Ribosome biogenesis; Transport.
FT CHAIN 1..206
FT /note="60S ribosomal subunit assembly/export protein LOC1"
FT /id="PRO_0000308790"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 144..206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 118..196
FT /evidence="ECO:0000255"
FT COMPBIAS 144..171
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 180..206
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 206 AA; 23806 MW; ECF4071AACD89273 CRC64;
MAPRQSKTAK RNKTQNKTRT VDSEVFSDSA AKNLLADQPK LTPKSKVKKI SKLALKKQQA
KIRLYGAKNG KEYREDQLNI PTLNKAIVPG VKAKRGKKGK KFVDDNDTLT MNRLVKSIND
KYDQVNESKL EKSRRLEEIR DLKRQEIERK EQQKKDKLEG KKDELRSKAS VARSTRRKNA
KARRADEESQ EQEEESPKKK KKVSFV