ID   LOC1_COCIM              Reviewed;         195 AA.
AC   Q1E403; J3KMC8;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 53.
DE   RecName: Full=60S ribosomal subunit assembly/export protein LOC1;
GN   Name=LOC1; ORFNames=CIMG_02710;
OS   Coccidioides immitis (strain RS) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=246410;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=RS;
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- FUNCTION: Required for efficient assembly and nuclear export of the 60S
CC       ribosomal subunit. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the 66S pre-ribosomal particle. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LOC1 family. {ECO:0000305}.
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DR   EMBL; GG704911; EAS37356.3; -; Genomic_DNA.
DR   RefSeq; XP_001248939.1; XM_001248938.2.
DR   AlphaFoldDB; Q1E403; -.
DR   SMR; Q1E403; -.
DR   STRING; 246410.Q1E403; -.
DR   EnsemblFungi; EAS37356; EAS37356; CIMG_02710.
DR   GeneID; 4567637; -.
DR   KEGG; cim:CIMG_02710; -.
DR   VEuPathDB; FungiDB:CIMG_02710; -.
DR   InParanoid; Q1E403; -.
DR   OMA; GQIESRM; -.
DR   OrthoDB; 1641629at2759; -.
DR   Proteomes; UP000001261; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003729; F:mRNA binding; IEA:InterPro.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   GO; GO:0042273; P:ribosomal large subunit biogenesis; IEA:InterPro.
DR   InterPro; IPR037650; Loc1.
DR   PANTHER; PTHR28028; PTHR28028; 1.
PE   3: Inferred from homology;
KW   Coiled coil; mRNA transport; Nucleus; Reference proteome;
KW   Ribosome biogenesis; Transport.
FT   CHAIN           1..195
FT                   /note="60S ribosomal subunit assembly/export protein LOC1"
FT                   /id="PRO_0000308792"
FT   REGION          1..74
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          136..195
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          124..166
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..41
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        42..73
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        136..185
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   195 AA;  22089 MW;  7393DAE31A54807D CRC64;
     MAPNRGASSS KQSNKSASKK SSSSSTLASK SRVSKSSANK NAKRPPPKEV KTKARTEKAL
     QKKTKKREYT EKELNLPALN MITPVGVQKP RGKKKGKVFV DDQESMMTIL AMVNAEKEGQ
     IESKIMKARQ MEEIREARRK EAEARQEQRK FKYEETKELL KRKRKNGGKE QQAKKDNDQS
     TTPPKKPNKK RVAFA