ID   LOC1_NEUCR              Reviewed;         209 AA.
AC   Q9HEG2;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=60S ribosomal subunit assembly/export protein loc-1;
GN   Name=loc-1; ORFNames=65E11.040, NCU01301;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12655011; DOI=10.1093/nar/gkg293;
RA   Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D.,
RA   Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
RT   "What's in the genome of a filamentous fungus? Analysis of the Neurospora
RT   genome sequence.";
RL   Nucleic Acids Res. 31:1944-1954(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Required for efficient assembly and nuclear export of the 60S
CC       ribosomal subunit. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the 66S pre-ribosomal particle. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LOC1 family. {ECO:0000305}.
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DR   EMBL; AL451021; CAC18288.1; -; Genomic_DNA.
DR   EMBL; CM002240; EAA32151.1; -; Genomic_DNA.
DR   RefSeq; XP_961387.1; XM_956294.2.
DR   AlphaFoldDB; Q9HEG2; -.
DR   SMR; Q9HEG2; -.
DR   STRING; 5141.EFNCRP00000004178; -.
DR   EnsemblFungi; EAA32151; EAA32151; NCU01301.
DR   GeneID; 3877531; -.
DR   KEGG; ncr:NCU01301; -.
DR   VEuPathDB; FungiDB:NCU01301; -.
DR   HOGENOM; CLU_096593_0_0_1; -.
DR   InParanoid; Q9HEG2; -.
DR   OMA; RESMNTI; -.
DR   Proteomes; UP000001805; Chromosome 2, Linkage Group V.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IBA:GO_Central.
DR   GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR   GO; GO:0008298; P:intracellular mRNA localization; IBA:GO_Central.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   GO; GO:0042273; P:ribosomal large subunit biogenesis; IBA:GO_Central.
DR   InterPro; IPR037650; Loc1.
DR   PANTHER; PTHR28028; PTHR28028; 1.
PE   3: Inferred from homology;
KW   Coiled coil; mRNA transport; Nucleus; Reference proteome;
KW   Ribosome biogenesis; Transport.
FT   CHAIN           1..209
FT                   /note="60S ribosomal subunit assembly/export protein loc-1"
FT                   /id="PRO_0000308799"
FT   REGION          1..53
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          135..209
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          126..170
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        16..37
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        135..161
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        170..193
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   209 AA;  23130 MW;  3AD1E085C2CE6D15 CRC64;
     MAPTKTIKNK HAANKSGIKG SKDAERSRND GVLKSKGKPK GKAHTLVTAS KGRPNIQELI
     ARKKKKKTYS EKELAIPELN MITPVGVTKP KGKKKGKVFV DDKESMATIL AIVQAEKEGQ
     IESKMIKARQ MEEIREARRA EAEKKEAERK ARLEETKDSL RKKRKRSKQS GGSKGDDDDD
     SRDVKEFSSA GTKAVKSKKK KSVSFAAPE