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LOL1_ARATH
ID   LOL1_ARATH              Reviewed;         154 AA.
AC   Q93ZB1; Q3ED39; Q9C7Y5;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=Protein LOL1;
DE   AltName: Full=Protein LSD ONE LIKE 1;
DE            Short=AtLOL1;
DE   AltName: Full=Putative zinc finger LOL1;
GN   Name=LOL1; OrderedLocusNames=At1g32540; ORFNames=T9G5.1;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND FUNCTION.
RC   STRAIN=cv. Columbia;
RX   PubMed=12732715; DOI=10.1073/pnas.1130421100;
RA   Epple P., Mack A.A., Morris V.R., Dangl J.L.;
RT   "Antagonistic control of oxidative stress-induced cell death in Arabidopsis
RT   by two related, plant-specific zinc finger proteins.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:6831-6836(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=cv. Columbia;
RX   PubMed=19423640; DOI=10.1093/dnares/dsp009;
RA   Iida K., Fukami-Kobayashi K., Toyoda A., Sakaki Y., Kobayashi M., Seki M.,
RA   Shinozaki K.;
RT   "Analysis of multiple occurrences of alternative splicing events in
RT   Arabidopsis thaliana using novel sequenced full-length cDNAs.";
RL   DNA Res. 16:155-164(2009).
CC   -!- FUNCTION: Positive regulator of reactive oxygen-induced cell death. May
CC       be involved in the repression of the copper/zinc superoxide dismutase
CC       CSD1 and CSD2 that detoxify accumulating superoxide before the reactive
CC       oxygen species (ROS) can trigger a cell death cascade. LSD1 and LOL1
CC       have antagonistic effects on CSD1 and CSD2 accumulation to regulate
CC       oxidative stress-induced cell death. {ECO:0000269|PubMed:12732715}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q93ZB1-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q93ZB1-2; Sequence=VSP_041105;
CC   -!- MISCELLANEOUS: Over-expression of LOL1 induces cell death.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAG51243.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=BX813858; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305};
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DR   EMBL; AY349618; AAQ55219.1; -; mRNA.
DR   EMBL; AC055769; AAG51243.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002684; AEE31498.1; -; Genomic_DNA.
DR   EMBL; CP002684; AEE31499.1; -; Genomic_DNA.
DR   EMBL; CP002684; AEE31500.1; -; Genomic_DNA.
DR   EMBL; AY057675; AAL15306.1; -; mRNA.
DR   EMBL; AY116951; AAM51585.1; -; mRNA.
DR   EMBL; BX813858; -; NOT_ANNOTATED_CDS; mRNA.
DR   PIR; H86450; H86450.
DR   RefSeq; NP_001117399.1; NM_001123927.2. [Q93ZB1-1]
DR   RefSeq; NP_001320333.1; NM_001333008.1.
DR   RefSeq; NP_001320335.1; NM_001333010.1.
DR   RefSeq; NP_564405.1; NM_102989.3. [Q93ZB1-1]
DR   RefSeq; NP_849742.2; NM_179411.3. [Q93ZB1-2]
DR   AlphaFoldDB; Q93ZB1; -.
DR   BioGRID; 25382; 5.
DR   IntAct; Q93ZB1; 6.
DR   STRING; 3702.AT1G32540.1; -.
DR   PaxDb; Q93ZB1; -.
DR   ProteomicsDB; 238462; -. [Q93ZB1-1]
DR   EnsemblPlants; AT1G32540.1; AT1G32540.1; AT1G32540. [Q93ZB1-2]
DR   EnsemblPlants; AT1G32540.2; AT1G32540.2; AT1G32540. [Q93ZB1-1]
DR   EnsemblPlants; AT1G32540.3; AT1G32540.3; AT1G32540. [Q93ZB1-1]
DR   GeneID; 840148; -.
DR   Gramene; AT1G32540.1; AT1G32540.1; AT1G32540. [Q93ZB1-2]
DR   Gramene; AT1G32540.2; AT1G32540.2; AT1G32540. [Q93ZB1-1]
DR   Gramene; AT1G32540.3; AT1G32540.3; AT1G32540. [Q93ZB1-1]
DR   KEGG; ath:AT1G32540; -.
DR   Araport; AT1G32540; -.
DR   TAIR; locus:2206649; AT1G32540.
DR   eggNOG; ENOG502RY0V; Eukaryota.
DR   HOGENOM; CLU_111765_0_0_1; -.
DR   InParanoid; Q93ZB1; -.
DR   OrthoDB; 1480977at2759; -.
DR   PhylomeDB; Q93ZB1; -.
DR   PRO; PR:Q93ZB1; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q93ZB1; baseline and differential.
DR   Genevisible; Q93ZB1; AT.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; ISS:TAIR.
DR   GO; GO:0098542; P:defense response to other organism; IMP:UniProtKB.
DR   GO; GO:0009626; P:plant-type hypersensitive response; IEA:UniProtKB-KW.
DR   GO; GO:0034052; P:positive regulation of plant-type hypersensitive response; IMP:UniProtKB.
DR   GO; GO:0043068; P:positive regulation of programmed cell death; IMP:TAIR.
DR   GO; GO:2000121; P:regulation of removal of superoxide radicals; IMP:UniProtKB.
DR   InterPro; IPR040319; LSD1-like.
DR   InterPro; IPR005735; Znf_LSD1.
DR   PANTHER; PTHR31747; PTHR31747; 1.
DR   Pfam; PF06943; zf-LSD1; 3.
DR   TIGRFAMs; TIGR01053; LSD1; 3.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Apoptosis; Hypersensitive response; Nucleus;
KW   Plant defense; Reference proteome.
FT   CHAIN           1..154
FT                   /note="Protein LOL1"
FT                   /id="PRO_0000408484"
FT   REGION          34..64
FT                   /note="Putative zinc finger 1"
FT   REGION          73..103
FT                   /note="Putative zinc finger 2"
FT   REGION          111..141
FT                   /note="Putative zinc finger 3"
FT   VAR_SEQ         1..26
FT                   /note="MPVPLAPYPTPPAPALAPSYNTPPAN -> MHTWKNQIFSDSQFVLLFMGKN
FT                   CSIIFPEPHLFISHVFIIHLNVLFLVKKINKNNLRFV (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:19423640"
FT                   /id="VSP_041105"
SQ   SEQUENCE   154 AA;  15872 MW;  7351A6A103CBEC4E CRC64;
     MPVPLAPYPT PPAPALAPSY NTPPANGSTS GQSQLVCSGC RNLLMYPVGA TSVCCAVCNA
     VTAVPPPGTE MAQLVCGGCH TLLMYIRGAT SVQCSCCHTV NLALEANQVA HVNCGNCMML
     LMYQYGARSV KCAVCNFVTS VGGSTSTTDS KFNN
 
 
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