LOLA3_DROME
ID LOLA3_DROME Reviewed; 787 AA.
AC Q7KQZ4; A4UZC4; Q0E9C9; Q867I7; Q867S0; Q867S9; Q8MKX5; Q95TS0;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 160.
DE RecName: Full=Longitudinals lacking protein, isoforms A/B/D/L;
GN Name=lola {ECO:0000312|FlyBase:FBgn0283521};
GN ORFNames=CG12052 {ECO:0000312|FlyBase:FBgn0283521};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1] {ECO:0000305, ECO:0000312|EMBL:BAC67588.1}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B; D AND L).
RC STRAIN=Canton-S {ECO:0000312|EMBL:BAC67588.1};
RC TISSUE=Embryo {ECO:0000269|PubMed:12853139}, and
RC Larva {ECO:0000269|PubMed:12853139};
RX PubMed=12853139; DOI=10.1016/s0378-1119(03)00554-7;
RA Ohsako T., Horiuchi T., Matsuo T., Komaya S., Aigaki T.;
RT "Drosophila lola encodes a family of BTB-transcription regulators with
RT highly variable C-terminal domains containing zinc finger motifs.";
RL Gene 311:59-69(2003).
RN [2] {ECO:0000312|EMBL:AAM68765.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000269|PubMed:10731132};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3] {ECO:0000305, ECO:0000312|EMBL:AAM68765.1}
RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4] {ECO:0000305, ECO:0000312|EMBL:AAL13815.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM D).
RC STRAIN=Berkeley {ECO:0000312|EMBL:AAL13815.1};
RC TISSUE=Embryo {ECO:0000269|PubMed:12537569};
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5] {ECO:0000305, ECO:0000312|EMBL:AAO49162.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
RC STRAIN=Berkeley {ECO:0000312|EMBL:AAO49162.1}; TISSUE=Embryo;
RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J.W., Champe M.,
RA Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R.A.,
RA Gonzalez M., Guarin H., Kronmiller B., Li P.W., Liao G., Miranda A.,
RA Mungall C.J., Nunoo J., Pacleb J.M., Paragas V., Park S., Patel S.,
RA Phouanenavong S., Wan K.H., Yu C., Lewis S.E., Rubin G.M., Celniker S.E.;
RL Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, AND DEVELOPMENTAL STAGE.
RX PubMed=8050351; DOI=10.1242/dev.120.6.1385;
RA Giniger E., Tietje K., Jan L.Y., Jan Y.N.;
RT "Lola encodes a putative transcription factor required for axon growth and
RT guidance in Drosophila.";
RL Development 120:1385-1398(1994).
RN [7] {ECO:0000305}
RP FUNCTION, AND MUTAGENESIS OF ALA-107.
RX PubMed=11880341; DOI=10.1242/dev.129.6.1317;
RA Crowner D., Madden K., Goeke S., Giniger E.;
RT "Lola regulates midline crossing of CNS axons in Drosophila.";
RL Development 129:1317-1325(2002).
RN [8]
RP TRANS-SPLICING.
RX PubMed=14522953; DOI=10.1101/gad.1137303;
RA Horiuchi T., Giniger E., Aigaki T.;
RT "Alternative trans-splicing of constant and variable exons of a Drosophila
RT axon guidance gene, lola.";
RL Genes Dev. 17:2496-2501(2003).
RN [9] {ECO:0000305}
RP INTERACTION WITH JIL-1, SUBCELLULAR LOCATION, AND DEVELOPMENTAL STAGE.
RX PubMed=12538650; DOI=10.1074/jbc.m213269200;
RA Zhang W., Wang Y., Long J., Girton J., Johansen J., Johansen K.M.;
RT "A developmentally regulated splice variant from the complex lola locus
RT encoding multiple different zinc finger domain proteins interacts with the
RT chromosomal kinase JIL-1.";
RL J. Biol. Chem. 278:11696-11704(2003).
RN [10]
RP DEVELOPMENTAL STAGE, TISSUE SPECIFICITY, AND MUTAGENESIS OF PRO-712.
RX PubMed=12897787; DOI=10.1038/nn1105;
RA Goeke S., Greene E.A., Grant P.K., Gates M.A., Crowner D., Aigaki T.,
RA Giniger E.;
RT "Alternative splicing of lola generates 19 transcription factors
RT controlling axon guidance in Drosophila.";
RL Nat. Neurosci. 6:917-924(2003).
CC -!- FUNCTION: Putative transcription factor required for axon growth and
CC guidance in the central and peripheral nervous systems. Repels CNS
CC axons away from the midline by promoting the expression of the midline
CC repellent sli and its receptor robo. {ECO:0000269|PubMed:11880341,
CC ECO:0000269|PubMed:8050351}.
CC -!- SUBUNIT: Isoform D interacts with JIL-1. {ECO:0000269|PubMed:12538650}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12538650,
CC ECO:0000269|PubMed:8050351}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=22;
CC Comment=Some isoforms may be generated by alternative trans-splicing
CC of exons sequentially encoded by the same DNA strand.;
CC Name=B; Synonyms=C {ECO:0000269|PubMed:12853139}, Ohsako-L
CC {ECO:0000303|PubMed:12853139};
CC IsoId=Q7KQZ4-1; Sequence=Displayed;
CC Name=A {ECO:0000269|PubMed:12853139}; Synonyms=Ohsako-D
CC {ECO:0000303|PubMed:12853139};
CC IsoId=Q7KQZ4-2; Sequence=VSP_051795, VSP_051798;
CC Name=D {ECO:0000303|PubMed:10731132}; Synonyms=E, Ohsako-F
CC {ECO:0000303|PubMed:12853139};
CC IsoId=Q7KQZ4-3; Sequence=VSP_051796, VSP_051799;
CC Name=L {ECO:0000269|PubMed:12853139}; Synonyms=Ohsako-C
CC {ECO:0000303|PubMed:12853139};
CC IsoId=Q7KQZ4-4; Sequence=VSP_051794, VSP_051797;
CC Name=F {ECO:0000269|PubMed:12853139}; Synonyms=Ohsako-I
CC {ECO:0000303|PubMed:12853139};
CC IsoId=Q867Z4-2; Sequence=External;
CC Name=G {ECO:0000269|PubMed:12853139}; Synonyms=Long
CC {ECO:0000303|PubMed:8050351}, Ohsako-T {ECO:0000303|PubMed:12853139},
CC R;
CC IsoId=P42283-1; Sequence=External;
CC Name=H {ECO:0000269|PubMed:12853139}; Synonyms=Ohsako-M
CC {ECO:0000303|PubMed:12853139};
CC IsoId=P42284-3; Sequence=External;
CC Name=I {ECO:0000269|PubMed:12853139}; Synonyms=Ohsako-K
CC {ECO:0000303|PubMed:12853139};
CC IsoId=Q867Z4-1; Sequence=External;
CC Name=J {ECO:0000269|PubMed:12853139}; Synonyms=Ohsako-O
CC {ECO:0000303|PubMed:12853139};
CC IsoId=Q9V5M6-2; Sequence=External;
CC Name=K {ECO:0000269|PubMed:12853139}; Synonyms=Ohsako-H
CC {ECO:0000303|PubMed:12853139};
CC IsoId=Q867Z4-3; Sequence=External;
CC Name=M {ECO:0000269|PubMed:12853139}; Synonyms=Short
CC {ECO:0000303|PubMed:8050351}, Ohsako-A {ECO:0000303|PubMed:12853139};
CC IsoId=P42284-1; Sequence=External;
CC Name=N {ECO:0000303|PubMed:10731132};
CC IsoId=Q9V5M3-1; Sequence=External;
CC Name=O {ECO:0000269|PubMed:12853139}; Synonyms=Ohsako-P
CC {ECO:0000303|PubMed:12853139};
CC IsoId=Q9V5M3-2; Sequence=External;
CC Name=P {ECO:0000269|PubMed:12853139}; Synonyms=Ohsako-N
CC {ECO:0000303|PubMed:12853139};
CC IsoId=Q9V5M6-1; Sequence=External;
CC Name=Q {ECO:0000269|PubMed:12853139}; Synonyms=Ohsako-B
CC {ECO:0000303|PubMed:12853139};
CC IsoId=Q9V5M6-3; Sequence=External;
CC Name=S {ECO:0000269|PubMed:12853139};
CC IsoId=Q9V5M6-4; Sequence=External;
CC Name=T {ECO:0000269|PubMed:12853139}; Synonyms=U
CC {ECO:0000303|PubMed:10731132}, Ohsako-J {ECO:0000303|PubMed:12853139};
CC IsoId=Q867Z4-5; Sequence=External;
CC Name=V {ECO:0000269|PubMed:12853139}; Synonyms=Ohsako-G
CC {ECO:0000303|PubMed:12853139};
CC IsoId=P42284-2; Sequence=External;
CC Name=W {ECO:0000269|PubMed:12853139}; Synonyms=Ohsako-Q
CC {ECO:0000303|PubMed:12853139};
CC IsoId=Q9V5M3-3; Sequence=External;
CC Name=X {ECO:0000269|PubMed:12853139}; Synonyms=Ohsako-S
CC {ECO:0000303|PubMed:12853139};
CC IsoId=Q9V5M3-4; Sequence=External;
CC Name=Y {ECO:0000269|PubMed:12853139}; Synonyms=Ohsako-R
CC {ECO:0000303|PubMed:12853139};
CC IsoId=Q9V5M3-5; Sequence=External;
CC Name=Z; Synonyms=Ohsako-E;
CC IsoId=Q9V5M6-5; Sequence=External;
CC -!- TISSUE SPECIFICITY: By stage 11, isoform B is expressed throughout the
CC mesoderm, whereas isoform A, isoform D and isoform L are expressed
CC throughout the ectoderm. Expression becomes restricted during later
CC stages; starting from stage 14 to 16, isoform B is expressed in muscle.
CC Isoform A, isoform D, and at low levels isoform B, are expressed in the
CC CNS. Expression is also seen in specific types of cells in the embryo;
CC isoform A and isoform L are expressed in a dynamic pattern in the
CC ventral neurogenic region starting at stage 7. Isoform L is expressed
CC around the tracheal pits at stage 11. {ECO:0000269|PubMed:12897787}.
CC -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically. At
CC least one isoform is present at each developmental stage. Isoform D is
CC restricted to early embryogenesis (at protein level).
CC {ECO:0000269|PubMed:12538650, ECO:0000269|PubMed:12897787,
CC ECO:0000269|PubMed:8050351}.
CC -!- MISCELLANEOUS: [Isoform B]: C-terminal exons may be joined by a trans-
CC splicing event. The exons are coded by the same DNA strand.
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DR EMBL; AB107274; BAC67579.1; -; mRNA.
DR EMBL; AB107275; BAC67580.1; -; mRNA.
DR EMBL; AB107277; BAC67582.1; -; mRNA.
DR EMBL; AB107283; BAC67588.1; -; mRNA.
DR EMBL; AB107294; BAC67599.1; -; mRNA.
DR EMBL; AB107295; BAC67600.1; -; mRNA.
DR EMBL; AB107297; BAC67602.1; -; mRNA.
DR EMBL; AB107303; BAC67608.1; -; mRNA.
DR EMBL; AB107314; BAC67619.1; -; mRNA.
DR EMBL; AB107315; BAC67620.1; -; mRNA.
DR EMBL; AB107317; BAC67622.1; -; mRNA.
DR EMBL; AB107323; BAC67628.1; -; mRNA.
DR EMBL; AB107334; BAC67639.1; -; mRNA.
DR EMBL; AB107335; BAC67640.1; -; mRNA.
DR EMBL; AB107337; BAC67642.1; -; mRNA.
DR EMBL; AB107343; BAC67648.1; -; mRNA.
DR EMBL; AE013599; AAF58775.3; -; Genomic_DNA.
DR EMBL; AE013599; AAF58776.3; -; Genomic_DNA.
DR EMBL; AE013599; AAM68765.1; -; Genomic_DNA.
DR EMBL; AE013599; AAM68766.1; -; Genomic_DNA.
DR EMBL; AE013599; AAO41430.1; -; Genomic_DNA.
DR EMBL; AY058586; AAL13815.1; -; mRNA.
DR EMBL; BT004909; AAO49162.1; -; mRNA.
DR RefSeq; NP_724946.1; NM_170618.5. [Q7KQZ4-1]
DR RefSeq; NP_724949.2; NM_170619.3. [Q7KQZ4-1]
DR RefSeq; NP_724950.1; NM_170620.4. [Q7KQZ4-3]
DR RefSeq; NP_724951.1; NM_170621.4. [Q7KQZ4-3]
DR RefSeq; NP_724953.2; NM_170623.6. [Q7KQZ4-2]
DR RefSeq; NP_788318.1; NM_176138.5. [Q7KQZ4-4]
DR AlphaFoldDB; Q7KQZ4; -.
DR SMR; Q7KQZ4; -.
DR BioGRID; 69126; 52.
DR IntAct; Q7KQZ4; 6.
DR DNASU; 44548; -.
DR EnsemblMetazoa; FBtr0089342; FBpp0088376; FBgn0283521. [Q7KQZ4-3]
DR EnsemblMetazoa; FBtr0089343; FBpp0088377; FBgn0283521. [Q7KQZ4-1]
DR EnsemblMetazoa; FBtr0089344; FBpp0088378; FBgn0283521. [Q7KQZ4-2]
DR EnsemblMetazoa; FBtr0089345; FBpp0088379; FBgn0283521. [Q7KQZ4-1]
DR EnsemblMetazoa; FBtr0089349; FBpp0088383; FBgn0283521. [Q7KQZ4-3]
DR EnsemblMetazoa; FBtr0089352; FBpp0088386; FBgn0283521. [Q7KQZ4-4]
DR GeneID; 44548; -.
DR UCSC; CG12052-RE; d. melanogaster.
DR CTD; 44548; -.
DR FlyBase; FBgn0283521; lola.
DR VEuPathDB; VectorBase:FBgn0283521; -.
DR GeneTree; ENSGT00940000174551; -.
DR HOGENOM; CLU_010740_4_0_1; -.
DR SignaLink; Q7KQZ4; -.
DR BioGRID-ORCS; 44548; 1 hit in 1 CRISPR screen.
DR ChiTaRS; lola; fly.
DR GenomeRNAi; 44548; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0283521; Expressed in cleaving embryo and 52 other tissues.
DR ExpressionAtlas; Q7KQZ4; baseline and differential.
DR Genevisible; Q7KQZ4; DM.
DR GO; GO:0005654; C:nucleoplasm; HDA:FlyBase.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:FlyBase.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007411; P:axon guidance; IMP:UniProtKB.
DR GO; GO:0016199; P:axon midline choice point recognition; IMP:UniProtKB.
DR GO; GO:0007409; P:axonogenesis; IMP:UniProtKB.
DR GO; GO:0048813; P:dendrite morphogenesis; IMP:FlyBase.
DR GO; GO:0008406; P:gonad development; IMP:FlyBase.
DR GO; GO:0035167; P:larval lymph gland hemopoiesis; IMP:FlyBase.
DR GO; GO:0007526; P:larval somatic muscle development; IMP:FlyBase.
DR GO; GO:0045476; P:nurse cell apoptotic process; IMP:FlyBase.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0007464; P:R3/R4 cell fate commitment; IMP:FlyBase.
DR GO; GO:0045467; P:R7 cell development; IMP:FlyBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:FlyBase.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00651; BTB; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00355; ZnF_C2H2; 2.
DR SUPFAM; SSF54695; SSF54695; 1.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Developmental protein; Differentiation; DNA-binding;
KW Metal-binding; Neurogenesis; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..787
FT /note="Longitudinals lacking protein, isoforms A/B/D/L"
FT /id="PRO_0000047074"
FT DOMAIN 32..97
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT ZN_FING 685..707
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 714..737
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 115..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 228..340
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 506..560
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 653..677
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 228..311
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 531..560
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 653..674
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 455..748
FT /note="DLSITRIAGLTWNEWNARLAMPLVTLREGVQPLVFPTDLSVDKQQGAAGLTA
FT KDVNVSGRKTPTDGGGCKSEPRAASTPARTHSSSNHSSNGNGSGKPTKTSSGGKLNHLT
FT EEEATALMLKAVAEKQAAAAAGTELSFGEDQASSGNGNSSDYPATLSGAVTFADVGGPA
FT GLCHINILNSISAMNNLISGSTAAGVGITTGSGQSPSNSGHNNSAGGGSSVLGGADNGA
FT GHPCPVCGRVYKLKSSLRNHQKWECGKEPQFQCPFCVYRAKQKMHIGRHMERMHKEKFK
FT LEDVKN -> DLKYDYKHSIFGSDDADQDQYKERFHCAVCNKSYLRKRHLQRHMRDECI
FT GIPPRFNCEFCSSRFRRKYHMVRHLVSKHGIPPAIAQMTTGSGSRSSISGSLDLKSGGG
FT LAGLQQMGGGGAGGGGSTGDCGASVGSAGSHNGCESPIPENLSLRKENYENENLSGSRC
FT TSPLPPHIMPIPTYGLTGAITAISAAAAVVEEQAAAAAAAAAIAEAQAKNNNESGGGRS
FT EVDDEDETLAAQAEAVAALGIKPEPVTPSKVQHLMNEEWNMKLGLQIISNSLLKERLMN
FT TMPFAYNNN (in isoform D)"
FT /evidence="ECO:0000303|PubMed:12537569,
FT ECO:0000303|PubMed:12853139"
FT /id="VSP_051796"
FT VAR_SEQ 455..706
FT /note="DLSITRIAGLTWNEWNARLAMPLVTLREGVQPLVFPTDLSVDKQQGAAGLTA
FT KDVNVSGRKTPTDGGGCKSEPRAASTPARTHSSSNHSSNGNGSGKPTKTSSGGKLNHLT
FT EEEATALMLKAVAEKQAAAAAGTELSFGEDQASSGNGNSSDYPATLSGAVTFADVGGPA
FT GLCHINILNSISAMNNLISGSTAAGVGITTGSGQSPSNSGHNNSAGGGSSVLGGADNGA
FT GHPCPVCGRVYKLKSSLRNHQKW -> GLQLIDDSSSSQQNHLNGSKLELMDGSSDDYH
FT QGSGSLHHFHAPQFDHFQGLLAGGNSVVGGAGNGGQEESFTCPQCYRTYRRHGTLRRHL
FT RQECGKGKSMVCSVCGHRTKRADHLRQHVRKKHPEIAMRSLFKRQQRAAAAAASAVEGE
FT DQKPETEIVDLVDMLDDGSVAAADEDHQHAYLVEDDDEDELPQHQQSQLTTEESTTSNY
FT YRQQLRQQALLQQALQQVAAAAAVVASGNSTTSTTELLNGEGL (in isoform A)"
FT /evidence="ECO:0000303|PubMed:12853139, ECO:0000303|Ref.5"
FT /id="VSP_051795"
FT VAR_SEQ 455..608
FT /note="DLSITRIAGLTWNEWNARLAMPLVTLREGVQPLVFPTDLSVDKQQGAAGLTA
FT KDVNVSGRKTPTDGGGCKSEPRAASTPARTHSSSNHSSNGNGSGKPTKTSSGGKLNHLT
FT EEEATALMLKAVAEKQAAAAAGTELSFGEDQASSGNGNSSDYP -> GLLELSLNQMFY
FT YDSEMPPPPIPPPVVVESPPASPPLAVVTPVVQLRRGKLRSRRRKAANSSNSTTKKSIP
FT PPTVRSSSAANLARNADMRDDGKLQCPQCPNAYTRLSALKRHLEFECGMLENFRCQVCD
FT AGFKRKDSLNRHCKVKKHNTKYLF (in isoform L)"
FT /evidence="ECO:0000303|PubMed:12853139"
FT /id="VSP_051794"
FT VAR_SEQ 609..787
FT /note="Missing (in isoform L)"
FT /evidence="ECO:0000303|PubMed:12853139"
FT /id="VSP_051797"
FT VAR_SEQ 707..787
FT /note="Missing (in isoform A)"
FT /evidence="ECO:0000303|PubMed:12853139, ECO:0000303|Ref.5"
FT /id="VSP_051798"
FT VAR_SEQ 749..787
FT /note="Missing (in isoform D)"
FT /evidence="ECO:0000303|PubMed:12537569,
FT ECO:0000303|PubMed:12853139"
FT /id="VSP_051799"
FT MUTAGEN 107
FT /note="A->V: In ORE120; defective in embryonic axon
FT guidance."
FT /evidence="ECO:0000269|PubMed:11880341"
FT MUTAGEN 712
FT /note="P->L: In ORE119; defective in embryonic axon
FT guidance."
FT /evidence="ECO:0000269|PubMed:12897787"
FT CONFLICT 520
FT /note="Missing (in Ref. 1; BAC67588/BAC67608/BAC67628/
FT BAC67648)"
FT /evidence="ECO:0000305"
FT CONFLICT 653
FT /note="T -> S (in Ref. 1; BAC67588/BAC67608/BAC67628/
FT BAC67648)"
FT /evidence="ECO:0000305"
FT CONFLICT Q7KQZ4-2:519
FT /note="N -> S (in Ref. 1; BAC67580/BAC67600/BAC67620/
FT BAC67640)"
FT /evidence="ECO:0000305"
FT CONFLICT Q7KQZ4-2:611
FT /note="E -> D (in Ref. 1; BAC67580/BAC67600/BAC67620/
FT BAC67640)"
FT /evidence="ECO:0000305"
FT CONFLICT Q7KQZ4-2:654
FT /note="T -> A (in Ref. 1; BAC67580/BAC67600/BAC67620/
FT BAC67640)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 787 AA; 82173 MW; 6F20570E6C1A4702 CRC64;
MDDDQQFCLR WNNHQSTLIS VFDTLLENET LVDCTLAAEG KFLKAHKVVL SACSPYFATL
LQEQYDKHPI FILKDVKYQE LRAMMDYMYR GEVNISQDQL AALLKAAESL QIKGLSDNRT
GGGVAPKPES SGHHRGGKLS GAYTLEQTKR ARLATGGAMD TSGDVSGSRE GSSSPSRRRR
KVRRRSMEND AHDNSNSSVL QAAASNQSIL QQTGAGLAVS ALVTTQLSSG PAAGTSSQAS
STQQQQPLTS TNVTKKTESA KLTSSTAAPA SGASASAAVQ QAHLHQQQAQ TTSDAINTEN
VQAQSQGGAQ GVQGDDEDID EGSAVGGPNS ATGPNPASAS ASAVHAGVVV KQLASVVDKS
SSNHKHKIKD NSVSSVGSEM VIEPKAEYDD DAHDENVEDL TLDEEDMTME ELDQTAGTSQ
GGEGSSQTYA TWQHDRSQDE LGLMAQDAQQ RDPQDLSITR IAGLTWNEWN ARLAMPLVTL
REGVQPLVFP TDLSVDKQQG AAGLTAKDVN VSGRKTPTDG GGCKSEPRAA STPARTHSSS
NHSSNGNGSG KPTKTSSGGK LNHLTEEEAT ALMLKAVAEK QAAAAAGTEL SFGEDQASSG
NGNSSDYPAT LSGAVTFADV GGPAGLCHIN ILNSISAMNN LISGSTAAGV GITTGSGQSP
SNSGHNNSAG GGSSVLGGAD NGAGHPCPVC GRVYKLKSSL RNHQKWECGK EPQFQCPFCV
YRAKQKMHIG RHMERMHKEK FKLEDVKNFA GSSGLDGDSS GATATAASVV AAAAALVSGV
ELHPHFS
