LOLA4_DROME
ID LOLA4_DROME Reviewed; 970 AA.
AC Q867Z4; A4UZC3; Q867F7; Q867K2; Q867T0; Q86BC3; Q8MKX6; Q8MZH5;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 165.
DE RecName: Full=Longitudinals lacking protein, isoforms F/I/K/T;
GN Name=lola {ECO:0000312|FlyBase:FBgn0283521};
GN ORFNames=CG12052 {ECO:0000312|FlyBase:FBgn0283521};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1] {ECO:0000305, ECO:0000312|EMBL:BAC67587.1}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS F; I; K AND T).
RC STRAIN=Canton-S {ECO:0000312|EMBL:BAC67585.1};
RC TISSUE=Larva {ECO:0000269|PubMed:12853139}, and
RC Pupae {ECO:0000269|PubMed:12853139};
RX PubMed=12853139; DOI=10.1016/s0378-1119(03)00554-7;
RA Ohsako T., Horiuchi T., Matsuo T., Komaya S., Aigaki T.;
RT "Drosophila lola encodes a family of BTB-transcription regulators with
RT highly variable C-terminal domains containing zinc finger motifs.";
RL Gene 311:59-69(2003).
RN [2] {ECO:0000312|EMBL:AAO41426.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000269|PubMed:10731132};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3] {ECO:0000305, ECO:0000312|EMBL:AAO41426.1}
RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 688-970 (ISOFORM I).
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, AND DEVELOPMENTAL STAGE.
RX PubMed=8050351; DOI=10.1242/dev.120.6.1385;
RA Giniger E., Tietje K., Jan L.Y., Jan Y.N.;
RT "Lola encodes a putative transcription factor required for axon growth and
RT guidance in Drosophila.";
RL Development 120:1385-1398(1994).
RN [6] {ECO:0000305}
RP FUNCTION, AND MUTAGENESIS OF ALA-107.
RX PubMed=11880341; DOI=10.1242/dev.129.6.1317;
RA Crowner D., Madden K., Goeke S., Giniger E.;
RT "Lola regulates midline crossing of CNS axons in Drosophila.";
RL Development 129:1317-1325(2002).
RN [7]
RP TRANS-SPLICING.
RX PubMed=14522953; DOI=10.1101/gad.1137303;
RA Horiuchi T., Giniger E., Aigaki T.;
RT "Alternative trans-splicing of constant and variable exons of a Drosophila
RT axon guidance gene, lola.";
RL Genes Dev. 17:2496-2501(2003).
RN [8] {ECO:0000305}
RP DEVELOPMENTAL STAGE.
RX PubMed=12538650; DOI=10.1074/jbc.m213269200;
RA Zhang W., Wang Y., Long J., Girton J., Johansen J., Johansen K.M.;
RT "A developmentally regulated splice variant from the complex lola locus
RT encoding multiple different zinc finger domain proteins interacts with the
RT chromosomal kinase JIL-1.";
RL J. Biol. Chem. 278:11696-11704(2003).
RN [9]
RP DEVELOPMENTAL STAGE, AND TISSUE SPECIFICITY.
RX PubMed=12897787; DOI=10.1038/nn1105;
RA Goeke S., Greene E.A., Grant P.K., Gates M.A., Crowner D., Aigaki T.,
RA Giniger E.;
RT "Alternative splicing of lola generates 19 transcription factors
RT controlling axon guidance in Drosophila.";
RL Nat. Neurosci. 6:917-924(2003).
CC -!- FUNCTION: Putative transcription factor required for axon growth and
CC guidance in the central and peripheral nervous systems. Repels CNS
CC axons away from the midline by promoting the expression of the midline
CC repellent sli and its receptor robo. {ECO:0000269|PubMed:11880341,
CC ECO:0000269|PubMed:8050351}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:8050351}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=22;
CC Comment=Some isoforms may be generated by alternative trans-splicing
CC of exons sequentially encoded by the same DNA strand.;
CC Name=I {ECO:0000269|PubMed:12853139}; Synonyms=Ohsako-K
CC {ECO:0000303|PubMed:12853139};
CC IsoId=Q867Z4-1; Sequence=Displayed;
CC Name=F {ECO:0000269|PubMed:12853139}; Synonyms=Ohsako-I
CC {ECO:0000303|PubMed:12853139};
CC IsoId=Q867Z4-2; Sequence=VSP_051803, VSP_051805;
CC Name=K {ECO:0000269|PubMed:12853139}; Synonyms=Ohsako-H
CC {ECO:0000303|PubMed:12853139};
CC IsoId=Q867Z4-3; Sequence=VSP_051801, VSP_051804;
CC Name=T {ECO:0000269|PubMed:12853139}; Synonyms=U
CC {ECO:0000303|PubMed:10731132}, Ohsako-J {ECO:0000303|PubMed:12853139};
CC IsoId=Q867Z4-5; Sequence=VSP_051802, VSP_051806;
CC Name=A {ECO:0000269|PubMed:12853139}; Synonyms=Ohsako-D
CC {ECO:0000303|PubMed:12853139};
CC IsoId=Q7KQZ4-2; Sequence=External;
CC Name=B; Synonyms=C {ECO:0000269|PubMed:12853139}, Ohsako-L
CC {ECO:0000303|PubMed:12853139};
CC IsoId=Q7KQZ4-1; Sequence=External;
CC Name=D {ECO:0000303|PubMed:10731132}; Synonyms=E, Ohsako-F
CC {ECO:0000303|PubMed:12853139};
CC IsoId=Q7KQZ4-3; Sequence=External;
CC Name=G {ECO:0000269|PubMed:12853139}; Synonyms=Long
CC {ECO:0000303|PubMed:8050351}, Ohsako-T {ECO:0000303|PubMed:12853139},
CC R;
CC IsoId=P42283-1; Sequence=External;
CC Name=H {ECO:0000269|PubMed:12853139}; Synonyms=Ohsako-M
CC {ECO:0000303|PubMed:12853139};
CC IsoId=P42284-3; Sequence=External;
CC Name=J {ECO:0000269|PubMed:12853139}; Synonyms=Ohsako-O
CC {ECO:0000303|PubMed:12853139};
CC IsoId=Q9V5M6-2; Sequence=External;
CC Name=L {ECO:0000269|PubMed:12853139}; Synonyms=Ohsako-C
CC {ECO:0000303|PubMed:12853139};
CC IsoId=Q7KQZ4-4; Sequence=External;
CC Name=M {ECO:0000269|PubMed:12853139}; Synonyms=Short
CC {ECO:0000303|PubMed:8050351}, Ohsako-A {ECO:0000303|PubMed:12853139};
CC IsoId=P42284-1; Sequence=External;
CC Name=N {ECO:0000303|PubMed:10731132};
CC IsoId=Q9V5M3-1; Sequence=External;
CC Name=O {ECO:0000269|PubMed:12853139}; Synonyms=Ohsako-P
CC {ECO:0000303|PubMed:12853139};
CC IsoId=Q9V5M3-2; Sequence=External;
CC Name=P {ECO:0000269|PubMed:12853139}; Synonyms=Ohsako-N
CC {ECO:0000303|PubMed:12853139};
CC IsoId=Q9V5M6-1; Sequence=External;
CC Name=Q {ECO:0000269|PubMed:12853139}; Synonyms=Ohsako-B
CC {ECO:0000303|PubMed:12853139};
CC IsoId=Q9V5M6-3; Sequence=External;
CC Name=S {ECO:0000269|PubMed:12853139};
CC IsoId=Q9V5M6-4; Sequence=External;
CC Name=V {ECO:0000269|PubMed:12853139}; Synonyms=Ohsako-G
CC {ECO:0000303|PubMed:12853139};
CC IsoId=P42284-2; Sequence=External;
CC Name=W {ECO:0000269|PubMed:12853139}; Synonyms=Ohsako-Q
CC {ECO:0000303|PubMed:12853139};
CC IsoId=Q9V5M3-3; Sequence=External;
CC Name=X {ECO:0000269|PubMed:12853139}; Synonyms=Ohsako-S
CC {ECO:0000303|PubMed:12853139};
CC IsoId=Q9V5M3-4; Sequence=External;
CC Name=Y {ECO:0000269|PubMed:12853139}; Synonyms=Ohsako-R
CC {ECO:0000303|PubMed:12853139};
CC IsoId=Q9V5M3-5; Sequence=External;
CC Name=Z; Synonyms=Ohsako-E;
CC IsoId=Q9V5M6-5; Sequence=External;
CC -!- TISSUE SPECIFICITY: By stage 11, isoform F is expressed throughout the
CC mesoderm whereas isoform T, and at low levels isoform I, is expressed
CC throughout the ectoderm. Isoform K is expressed in both mesoderm and
CC ectoderm. Expression becomes restricted during later stages; starting
CC from stage 14 to 15, isoform F is expressed in the gut. Isoform I is
CC expressed in the CNS. Isoform I and isoform F show expression in the
CC epithelium starting at stage 14, though for isoform I the CNS
CC expression remains predominant. Expression is also seen in specific
CC types of cells in the embryo; isoform K is expressed in the ventral
CC furrow at stage 5 and in a dynamic pattern in the ventral neurogenic
CC region starting at stage 7. Isoform T is expressed around the tracheal
CC pits at stage 11. Isoform F shows transient enrichment in a dorsal cell
CC layer in the CNS at stages 13 and 14. {ECO:0000269|PubMed:12897787}.
CC -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically. At
CC least one isoform is present at each developmental stage.
CC {ECO:0000269|PubMed:12538650, ECO:0000269|PubMed:12897787,
CC ECO:0000269|PubMed:8050351}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM27509.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB107279; BAC67584.1; -; mRNA.
DR EMBL; AB107280; BAC67585.1; -; mRNA.
DR EMBL; AB107281; BAC67586.1; -; mRNA.
DR EMBL; AB107282; BAC67587.1; -; mRNA.
DR EMBL; AB107299; BAC67604.1; -; mRNA.
DR EMBL; AB107300; BAC67605.1; -; mRNA.
DR EMBL; AB107301; BAC67606.1; -; mRNA.
DR EMBL; AB107302; BAC67607.1; -; mRNA.
DR EMBL; AB107319; BAC67624.1; -; mRNA.
DR EMBL; AB107320; BAC67625.1; -; mRNA.
DR EMBL; AB107321; BAC67626.1; -; mRNA.
DR EMBL; AB107322; BAC67627.1; -; mRNA.
DR EMBL; AB107339; BAC67644.1; -; mRNA.
DR EMBL; AB107340; BAC67645.1; -; mRNA.
DR EMBL; AB107341; BAC67646.1; -; mRNA.
DR EMBL; AB107342; BAC67647.1; -; mRNA.
DR EMBL; AE013599; AAM68764.3; -; Genomic_DNA.
DR EMBL; AE013599; AAM68767.2; -; Genomic_DNA.
DR EMBL; AE013599; AAO41426.1; -; Genomic_DNA.
DR EMBL; AE013599; AAO41427.1; -; Genomic_DNA.
DR EMBL; AE013599; AAO41428.1; -; Genomic_DNA.
DR EMBL; AY102680; AAM27509.1; ALT_INIT; mRNA.
DR RefSeq; NP_724952.2; NM_170622.6. [Q867Z4-2]
DR RefSeq; NP_788308.3; NM_176128.5. [Q867Z4-1]
DR RefSeq; NP_788313.1; NM_176133.5. [Q867Z4-1]
DR RefSeq; NP_788314.1; NM_176134.4. [Q867Z4-5]
DR RefSeq; NP_788315.1; NM_176135.4. [Q867Z4-5]
DR RefSeq; NP_788316.2; NM_176136.5. [Q867Z4-3]
DR AlphaFoldDB; Q867Z4; -.
DR SMR; Q867Z4; -.
DR BioGRID; 69126; 52.
DR IntAct; Q867Z4; 10.
DR STRING; 7227.FBpp0088384; -.
DR PaxDb; Q867Z4; -.
DR DNASU; 44548; -.
DR EnsemblMetazoa; FBtr0089348; FBpp0088382; FBgn0283521. [Q867Z4-2]
DR EnsemblMetazoa; FBtr0089350; FBpp0088384; FBgn0283521. [Q867Z4-1]
DR EnsemblMetazoa; FBtr0089351; FBpp0088385; FBgn0283521. [Q867Z4-5]
DR EnsemblMetazoa; FBtr0089353; FBpp0088387; FBgn0283521. [Q867Z4-3]
DR EnsemblMetazoa; FBtr0089359; FBpp0088393; FBgn0283521. [Q867Z4-5]
DR EnsemblMetazoa; FBtr0343132; FBpp0309831; FBgn0283521. [Q867Z4-1]
DR GeneID; 44548; -.
DR UCSC; CG12052-RU; d. melanogaster.
DR CTD; 44548; -.
DR FlyBase; FBgn0283521; lola.
DR VEuPathDB; VectorBase:FBgn0283521; -.
DR eggNOG; ENOG502RYRA; Eukaryota.
DR GeneTree; ENSGT00940000174551; -.
DR HOGENOM; CLU_010740_1_0_1; -.
DR InParanoid; Q867Z4; -.
DR PhylomeDB; Q867Z4; -.
DR SignaLink; Q867Z4; -.
DR BioGRID-ORCS; 44548; 1 hit in 1 CRISPR screen.
DR ChiTaRS; lola; fly.
DR GenomeRNAi; 44548; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0283521; Expressed in cleaving embryo and 52 other tissues.
DR ExpressionAtlas; Q867Z4; baseline and differential.
DR Genevisible; Q867Z4; DM.
DR GO; GO:0005737; C:cytoplasm; IDA:FlyBase.
DR GO; GO:0005654; C:nucleoplasm; HDA:FlyBase.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IDA:FlyBase.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:FlyBase.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007411; P:axon guidance; IMP:UniProtKB.
DR GO; GO:0016199; P:axon midline choice point recognition; IMP:UniProtKB.
DR GO; GO:0007409; P:axonogenesis; IMP:UniProtKB.
DR GO; GO:0048813; P:dendrite morphogenesis; IMP:FlyBase.
DR GO; GO:0008406; P:gonad development; IMP:FlyBase.
DR GO; GO:0035167; P:larval lymph gland hemopoiesis; IMP:FlyBase.
DR GO; GO:0007526; P:larval somatic muscle development; IMP:FlyBase.
DR GO; GO:0045476; P:nurse cell apoptotic process; IMP:FlyBase.
DR GO; GO:0006964; P:positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria; HMP:FlyBase.
DR GO; GO:0061059; P:positive regulation of peptidoglycan recognition protein signaling pathway; HMP:FlyBase.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0007464; P:R3/R4 cell fate commitment; IMP:FlyBase.
DR GO; GO:0045467; P:R7 cell development; IMP:FlyBase.
DR GO; GO:1902667; P:regulation of axon guidance; IMP:FlyBase.
DR GO; GO:0010468; P:regulation of gene expression; IMP:FlyBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:FlyBase.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00651; BTB; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00355; ZnF_C2H2; 2.
DR SUPFAM; SSF54695; SSF54695; 1.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Developmental protein; Differentiation; DNA-binding;
KW Metal-binding; Neurogenesis; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..970
FT /note="Longitudinals lacking protein, isoforms F/I/K/T"
FT /id="PRO_0000047075"
FT DOMAIN 32..97
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT ZN_FING 903..925
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 933..955
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 115..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 228..340
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 447..468
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 790..843
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 228..311
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 453..467
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 790..828
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 829..843
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 455..575
FT /note="ASKQDKGEQTEGAQDEFELDDCLLESNDIVITQNKDGFVLHVKKLGNITAAK
FT LEENQAVAQQQGQAAVTVTGPAGQPTPTITELLNAAAASHSEPKPTLTTLTSTPIKLPS
FT SECELINIKK -> ENSWTISVKSVTSLNNVSPSNNSHICPRCEKAYTYKKNLSRHLRY
FT ECGQLPTEKCRHCSYVARYKHSLNMHVKTQHPEQISDTFAGSSGSSDGVRDRRGRSLVR
FT GLFDSAKGEKFLDYLNN (in isoform T)"
FT /evidence="ECO:0000303|PubMed:12853139"
FT /id="VSP_051802"
FT VAR_SEQ 455..546
FT /note="ASKQDKGEQTEGAQDEFELDDCLLESNDIVITQNKDGFVLHVKKLGNITAAK
FT LEENQAVAQQQGQAAVTVTGPAGQPTPTITELLNAAAASH -> DFVLTWYQHACDQCG
FT KSYKTRKSLSRHRRFECRFTTERPIFQCPSCNYAAKRSDNLTKHIKTHFAKMKKDFLPL
FT AFQMQASTGIATKWEATA (in isoform K)"
FT /evidence="ECO:0000303|PubMed:12853139"
FT /id="VSP_051801"
FT VAR_SEQ 456..565
FT /note="SKQDKGEQTEGAQDEFELDDCLLESNDIVITQNKDGFVLHVKKLGNITAAKL
FT EENQAVAQQQGQAAVTVTGPAGQPTPTITELLNAAAASHSEPKPTLTTLTSTPIKLPS
FT -> PSSYVSNSSQTPPPIGGSSSASSAQALIRDYWYELKFSDLFKFINPDGRYQCPRFN
FT CLKSYKDASSLQRHIRYECGGQKKFRCLMCGKAFSQSSHLKRHLESGVCVKYYL (in
FT isoform F)"
FT /evidence="ECO:0000303|PubMed:12853139"
FT /id="VSP_051803"
FT VAR_SEQ 547..970
FT /note="Missing (in isoform K)"
FT /evidence="ECO:0000303|PubMed:12853139"
FT /id="VSP_051804"
FT VAR_SEQ 566..970
FT /note="Missing (in isoform F)"
FT /evidence="ECO:0000303|PubMed:12853139"
FT /id="VSP_051805"
FT VAR_SEQ 576..970
FT /note="Missing (in isoform T)"
FT /evidence="ECO:0000303|PubMed:12853139"
FT /id="VSP_051806"
FT MUTAGEN 107
FT /note="A->V: In ORE120; defective in embryonic axon
FT guidance."
FT /evidence="ECO:0000269|PubMed:11880341"
SQ SEQUENCE 970 AA; 105812 MW; 1AFE2AD0AF7939F0 CRC64;
MDDDQQFCLR WNNHQSTLIS VFDTLLENET LVDCTLAAEG KFLKAHKVVL SACSPYFATL
LQEQYDKHPI FILKDVKYQE LRAMMDYMYR GEVNISQDQL AALLKAAESL QIKGLSDNRT
GGGVAPKPES SGHHRGGKLS GAYTLEQTKR ARLATGGAMD TSGDVSGSRE GSSSPSRRRR
KVRRRSMEND AHDNSNSSVL QAAASNQSIL QQTGAGLAVS ALVTTQLSSG PAAGTSSQAS
STQQQQPLTS TNVTKKTESA KLTSSTAAPA SGASASAAVQ QAHLHQQQAQ TTSDAINTEN
VQAQSQGGAQ GVQGDDEDID EGSAVGGPNS ATGPNPASAS ASAVHAGVVV KQLASVVDKS
SSNHKHKIKD NSVSSVGSEM VIEPKAEYDD DAHDENVEDL TLDEEDMTME ELDQTAGTSQ
GGEGSSQTYA TWQHDRSQDE LGLMAQDAQQ RDPQASKQDK GEQTEGAQDE FELDDCLLES
NDIVITQNKD GFVLHVKKLG NITAAKLEEN QAVAQQQGQA AVTVTGPAGQ PTPTITELLN
AAAASHSEPK PTLTTLTSTP IKLPSSECEL INIKKIIPAT TTIATHHPHT SSTIIHPHHI
IQHVSQEPHH QEHHQQHQTI HIEEVPQTSQ QHHQQQHHHQ LQTVQPTHTQ VQSIITAHPG
QTINLVGLRN VQLADSKPIA SRIRYSRGKI IGPTVQNLQI VETHEPIQHQ HHELSDGTKY
EISEIDLNNP NASAAIISDL VKYAEIDDIE LPDGTKIGIG FAPSEITEHM QTSGGETHIT
TIEHEPQELQ TVHQHEQTQQ THHIHAGQLQ THHIQTVVQS SSGQQQHDQQ QHHQHHSIEL
QDDDGVETIT PEELGMHDSS KSYTILTTRP MKEESEHDPS GMTYELSLSD SSLGPCDDPE
SRYVCRHCGK KYRWKSTLRR HENVECGGKE PCHPCPYCSY KAKQRGNLGV HVRKHHPEKP
QLESKRGRKV
