LOLA5_DROME
ID LOLA5_DROME Reviewed; 963 AA.
AC Q9V5M6; Q058V9; Q4AB07; Q867J5; Q867M8; Q867P1; Q867T8; Q86BC2; Q8MKX4;
AC Q9V5M5;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 4.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=Longitudinals lacking protein, isoforms J/P/Q/S/Z;
GN Name=lola {ECO:0000312|FlyBase:FBgn0283521};
GN ORFNames=CG12052 {ECO:0000312|FlyBase:FBgn0283521};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1] {ECO:0000305, ECO:0000312|EMBL:BAC67590.1}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS J; P; Q AND Z).
RC STRAIN=Canton-S {ECO:0000312|EMBL:BAC67590.1};
RC TISSUE=Embryo {ECO:0000269|PubMed:12853139},
RC Larva {ECO:0000269|PubMed:12853139}, and
RC Pupae {ECO:0000269|PubMed:12853139};
RX PubMed=12853139; DOI=10.1016/s0378-1119(03)00554-7;
RA Ohsako T., Horiuchi T., Matsuo T., Komaya S., Aigaki T.;
RT "Drosophila lola encodes a family of BTB-transcription regulators with
RT highly variable C-terminal domains containing zinc finger motifs.";
RL Gene 311:59-69(2003).
RN [2] {ECO:0000312|EMBL:AAF58778.4}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000269|PubMed:10731132};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3] {ECO:0000305, ECO:0000312|EMBL:AAF58778.4}
RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley;
RA Stapleton M., Carlson J.W., Frise E., Kapadia B., Park S., Wan K.H., Yu C.,
RA Celniker S.E.;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, AND DEVELOPMENTAL STAGE.
RX PubMed=8050351; DOI=10.1242/dev.120.6.1385;
RA Giniger E., Tietje K., Jan L.Y., Jan Y.N.;
RT "Lola encodes a putative transcription factor required for axon growth and
RT guidance in Drosophila.";
RL Development 120:1385-1398(1994).
RN [6] {ECO:0000305}
RP FUNCTION, AND MUTAGENESIS OF ALA-107.
RX PubMed=11880341; DOI=10.1242/dev.129.6.1317;
RA Crowner D., Madden K., Goeke S., Giniger E.;
RT "Lola regulates midline crossing of CNS axons in Drosophila.";
RL Development 129:1317-1325(2002).
RN [7]
RP TRANS-SPLICING.
RX PubMed=14522953; DOI=10.1101/gad.1137303;
RA Horiuchi T., Giniger E., Aigaki T.;
RT "Alternative trans-splicing of constant and variable exons of a Drosophila
RT axon guidance gene, lola.";
RL Genes Dev. 17:2496-2501(2003).
RN [8] {ECO:0000305}
RP DEVELOPMENTAL STAGE.
RX PubMed=12538650; DOI=10.1074/jbc.m213269200;
RA Zhang W., Wang Y., Long J., Girton J., Johansen J., Johansen K.M.;
RT "A developmentally regulated splice variant from the complex lola locus
RT encoding multiple different zinc finger domain proteins interacts with the
RT chromosomal kinase JIL-1.";
RL J. Biol. Chem. 278:11696-11704(2003).
RN [9]
RP DEVELOPMENTAL STAGE, AND TISSUE SPECIFICITY.
RX PubMed=12897787; DOI=10.1038/nn1105;
RA Goeke S., Greene E.A., Grant P.K., Gates M.A., Crowner D., Aigaki T.,
RA Giniger E.;
RT "Alternative splicing of lola generates 19 transcription factors
RT controlling axon guidance in Drosophila.";
RL Nat. Neurosci. 6:917-924(2003).
CC -!- FUNCTION: Putative transcription factor required for axon growth and
CC guidance in the central and peripheral nervous systems. Repels CNS
CC axons away from the midline by promoting the expression of the midline
CC repellent sli and its receptor robo. {ECO:0000269|PubMed:11880341,
CC ECO:0000269|PubMed:8050351}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:8050351}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=22;
CC Comment=Some isoforms may be generated by alternative trans-splicing
CC of exons sequentially encoded by the same DNA strand.;
CC Name=P {ECO:0000269|PubMed:12853139}; Synonyms=Ohsako-N
CC {ECO:0000303|PubMed:12853139};
CC IsoId=Q9V5M6-1; Sequence=Displayed;
CC Name=J {ECO:0000269|PubMed:12853139}; Synonyms=Ohsako-O
CC {ECO:0000303|PubMed:12853139};
CC IsoId=Q9V5M6-2; Sequence=VSP_051809, VSP_051812;
CC Name=Q {ECO:0000269|PubMed:12853139}; Synonyms=Ohsako-B
CC {ECO:0000303|PubMed:12853139};
CC IsoId=Q9V5M6-3; Sequence=VSP_051807, VSP_051810;
CC Name=S {ECO:0000269|PubMed:12853139};
CC IsoId=Q9V5M6-4; Sequence=VSP_017255, VSP_017256;
CC Name=Z; Synonyms=Ohsako-E;
CC IsoId=Q9V5M6-5; Sequence=VSP_051808, VSP_051811;
CC Name=A {ECO:0000269|PubMed:12853139}; Synonyms=Ohsako-D
CC {ECO:0000303|PubMed:12853139};
CC IsoId=Q7KQZ4-2; Sequence=External;
CC Name=B; Synonyms=C {ECO:0000269|PubMed:12853139}, Ohsako-L
CC {ECO:0000303|PubMed:12853139};
CC IsoId=Q7KQZ4-1; Sequence=External;
CC Name=D {ECO:0000303|PubMed:10731132}; Synonyms=E, Ohsako-F
CC {ECO:0000303|PubMed:12853139};
CC IsoId=Q7KQZ4-3; Sequence=External;
CC Name=F {ECO:0000269|PubMed:12853139}; Synonyms=Ohsako-I
CC {ECO:0000303|PubMed:12853139};
CC IsoId=Q867Z4-2; Sequence=External;
CC Name=G {ECO:0000269|PubMed:12853139}; Synonyms=Long
CC {ECO:0000303|PubMed:8050351}, Ohsako-T {ECO:0000303|PubMed:12853139},
CC R;
CC IsoId=P42283-1; Sequence=External;
CC Name=H {ECO:0000269|PubMed:12853139}; Synonyms=Ohsako-M
CC {ECO:0000303|PubMed:12853139};
CC IsoId=P42284-3; Sequence=External;
CC Name=I {ECO:0000269|PubMed:12853139}; Synonyms=Ohsako-K
CC {ECO:0000303|PubMed:12853139};
CC IsoId=Q867Z4-1; Sequence=External;
CC Name=K {ECO:0000269|PubMed:12853139}; Synonyms=Ohsako-H
CC {ECO:0000303|PubMed:12853139};
CC IsoId=Q867Z4-3; Sequence=External;
CC Name=L {ECO:0000269|PubMed:12853139}; Synonyms=Ohsako-C
CC {ECO:0000303|PubMed:12853139};
CC IsoId=Q7KQZ4-4; Sequence=External;
CC Name=M {ECO:0000269|PubMed:12853139}; Synonyms=Short
CC {ECO:0000303|PubMed:8050351}, Ohsako-A {ECO:0000303|PubMed:12853139};
CC IsoId=P42284-1; Sequence=External;
CC Name=N {ECO:0000303|PubMed:10731132};
CC IsoId=Q9V5M3-1; Sequence=External;
CC Name=O {ECO:0000269|PubMed:12853139}; Synonyms=Ohsako-P
CC {ECO:0000303|PubMed:12853139};
CC IsoId=Q9V5M3-2; Sequence=External;
CC Name=T {ECO:0000269|PubMed:12853139}; Synonyms=U
CC {ECO:0000303|PubMed:10731132}, Ohsako-J {ECO:0000303|PubMed:12853139};
CC IsoId=Q867Z4-5; Sequence=External;
CC Name=V {ECO:0000269|PubMed:12853139}; Synonyms=Ohsako-G
CC {ECO:0000303|PubMed:12853139};
CC IsoId=P42284-2; Sequence=External;
CC Name=W {ECO:0000269|PubMed:12853139}; Synonyms=Ohsako-Q
CC {ECO:0000303|PubMed:12853139};
CC IsoId=Q9V5M3-3; Sequence=External;
CC Name=X {ECO:0000269|PubMed:12853139}; Synonyms=Ohsako-S
CC {ECO:0000303|PubMed:12853139};
CC IsoId=Q9V5M3-4; Sequence=External;
CC Name=Y {ECO:0000269|PubMed:12853139}; Synonyms=Ohsako-R
CC {ECO:0000303|PubMed:12853139};
CC IsoId=Q9V5M3-5; Sequence=External;
CC -!- TISSUE SPECIFICITY: By stage 11, isoform Q, isoform P and isoform Z are
CC expressed throughout the mesoderm. From stage 15, expression of isoform
CC P expands to all tissues, whereas expression of isoform Z and isoform Q
CC becomes restricted during later stages; starting from stage 14 to 16,
CC isoform Z is expressed in muscle, and isoform Q and isoform Z are
CC expressed in the CNS. For some isoforms, expression is also seen in
CC specific types of cells in the embryo; isoform Z is expressed in the
CC ventral furrow at stage 5, and isoform Q is expressed around the
CC tracheal pits at stage 11. Isoform Z also shows transient enrichment in
CC a dorsal cell layer in the CNS at stages 13 and 14.
CC {ECO:0000269|PubMed:12897787}.
CC -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically. At
CC least one isoform is present at each developmental stage.
CC {ECO:0000269|PubMed:12538650, ECO:0000269|PubMed:12897787,
CC ECO:0000269|PubMed:8050351}.
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DR EMBL; AB107273; BAC67578.1; -; mRNA.
DR EMBL; AB107276; BAC67581.1; -; mRNA.
DR EMBL; AB107285; BAC67590.1; -; mRNA.
DR EMBL; AB107286; BAC67591.1; -; mRNA.
DR EMBL; AB107293; BAC67598.1; -; mRNA.
DR EMBL; AB107296; BAC67601.1; -; mRNA.
DR EMBL; AB107305; BAC67610.1; -; mRNA.
DR EMBL; AB107306; BAC67611.1; -; mRNA.
DR EMBL; AB107313; BAC67618.1; -; mRNA.
DR EMBL; AB107316; BAC67621.1; -; mRNA.
DR EMBL; AB107325; BAC67630.1; -; mRNA.
DR EMBL; AB107326; BAC67631.1; -; mRNA.
DR EMBL; AB107333; BAC67638.1; -; mRNA.
DR EMBL; AB107336; BAC67641.1; -; mRNA.
DR EMBL; AB107345; BAC67650.1; -; mRNA.
DR EMBL; AB107346; BAC67651.1; -; mRNA.
DR EMBL; AE013599; AAF58778.4; -; Genomic_DNA.
DR EMBL; AE013599; AAF58779.3; -; Genomic_DNA.
DR EMBL; AE013599; AAM68768.2; -; Genomic_DNA.
DR EMBL; AE013599; AAO41429.1; -; Genomic_DNA.
DR EMBL; AE013599; AAZ52818.1; -; Genomic_DNA.
DR EMBL; BT029109; ABJ17042.1; -; mRNA.
DR RefSeq; NP_001027400.1; NM_001032229.3. [Q9V5M6-5]
DR RefSeq; NP_788310.2; NM_176130.5. [Q9V5M6-2]
DR RefSeq; NP_788311.2; NM_176131.5. [Q9V5M6-1]
DR RefSeq; NP_788319.1; NM_176139.3. [Q9V5M6-3]
DR AlphaFoldDB; Q9V5M6; -.
DR SMR; Q9V5M6; -.
DR BioGRID; 69126; 52.
DR IntAct; Q9V5M6; 1.
DR DNASU; 44548; -.
DR EnsemblMetazoa; FBtr0089355; FBpp0088389; FBgn0283521. [Q9V5M6-1]
DR EnsemblMetazoa; FBtr0089356; FBpp0088390; FBgn0283521. [Q9V5M6-3]
DR EnsemblMetazoa; FBtr0089360; FBpp0088394; FBgn0283521. [Q9V5M6-2]
DR EnsemblMetazoa; FBtr0100286; FBpp0099680; FBgn0283521. [Q9V5M6-5]
DR GeneID; 44548; -.
DR CTD; 44548; -.
DR FlyBase; FBgn0283521; lola.
DR VEuPathDB; VectorBase:FBgn0283521; -.
DR GeneTree; ENSGT00940000174551; -.
DR HOGENOM; CLU_010740_2_0_1; -.
DR OMA; RRHMRKE; -.
DR SignaLink; Q9V5M6; -.
DR BioGRID-ORCS; 44548; 1 hit in 1 CRISPR screen.
DR ChiTaRS; lola; fly.
DR GenomeRNAi; 44548; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0283521; Expressed in cleaving embryo and 52 other tissues.
DR ExpressionAtlas; Q9V5M6; baseline and differential.
DR Genevisible; Q9V5M6; DM.
DR GO; GO:0005654; C:nucleoplasm; HDA:FlyBase.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:FlyBase.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007411; P:axon guidance; IMP:UniProtKB.
DR GO; GO:0016199; P:axon midline choice point recognition; IMP:UniProtKB.
DR GO; GO:0007409; P:axonogenesis; IMP:UniProtKB.
DR GO; GO:0048813; P:dendrite morphogenesis; IMP:FlyBase.
DR GO; GO:0008406; P:gonad development; IMP:FlyBase.
DR GO; GO:0035167; P:larval lymph gland hemopoiesis; IMP:FlyBase.
DR GO; GO:0007526; P:larval somatic muscle development; IMP:FlyBase.
DR GO; GO:0045476; P:nurse cell apoptotic process; IMP:FlyBase.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0007464; P:R3/R4 cell fate commitment; IMP:FlyBase.
DR GO; GO:0045467; P:R7 cell development; IMP:FlyBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:FlyBase.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00651; BTB; 1.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Developmental protein; Differentiation; DNA-binding;
KW Metal-binding; Neurogenesis; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..963
FT /note="Longitudinals lacking protein, isoforms J/P/Q/S/Z"
FT /id="PRO_0000047076"
FT DOMAIN 32..97
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT ZN_FING 849..871
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 878..901
FT /note="C2H2-type 2; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 115..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 228..340
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 447..469
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 482..520
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 900..963
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 228..311
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 494..520
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 900..915
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 932..963
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 455..757
FT /note="DEAGQNEGGESRIRVRNWLMLADKSIIGKSSDEPSDKLTQSKKSLISDAKTT
FT NKTSTPIRPKVSTTTTSTSTAAAAAAAATIAAKQAAAAIASSNINNNNSSLTQTVTQTV
FT TRIGSIGRTTIACITPANNGNKSSSSNCNVDAASAAALAAAGVELDSIDDTMTEVIVKI
FT ENPESMPLNDDEDDAVCNEAIEDENTFDYDLKLGSPLSWTYDAVKIENEEFEDSYLMDN
FT DDDDDDLLTTAAATQKHAKQSNEKQMAGSMVAGAGSGGAVKKIVLSAQQQQQLLEQQQH
FT LQHLQLQPTSQSLQI -> DFGRLSPNRRNYNLLGGIKSSPYNSPIGTPVIKFEPGSGQ
FT EDHNEHKSGRVTPTAHCPGNLLVPKTQPRHGNGDNDDSNDEDSMEPCDLRIDLAKAFLA
FT AAQSGAATTLPLGHHHHHGHHPHGRTLPNLIYPAVPVKVPRPDTPTRRYSSSSGPVQDA
FT ASSVAVQFVAAAAAAGLAANNTSASTNTGGGASTSAAAAAAAAAAAAAAAAAAGGSVAG
FT NWSSGGGSGGAGGGIGGGGSGGGGGGGGGGAYACDRCGNTYARPHSLNRHVRFECGVEP
FT KFECPICHKKSKHKHNLVLHMRTHQHR (in isoform J)"
FT /evidence="ECO:0000303|PubMed:12853139"
FT /id="VSP_051809"
FT VAR_SEQ 455..720
FT /note="DEAGQNEGGESRIRVRNWLMLADKSIIGKSSDEPSDKLTQSKKSLISDAKTT
FT NKTSTPIRPKVSTTTTSTSTAAAAAAAATIAAKQAAAAIASSNINNNNSSLTQTVTQTV
FT TRIGSIGRTTIACITPANNGNKSSSSNCNVDAASAAALAAAGVELDSIDDTMTEVIVKI
FT ENPESMPLNDDEDDAVCNEAIEDENTFDYDLKLGSPLSWTYDAVKIENEEFEDSYLMDN
FT DDDDDDLLTTAAATQKHAKQSNEKQMAGSMVAGAGSG -> ARTQHEHIHTTPPAISLF
FT LNSTTPYFDSLSLSVLSVRIVKQSQQILDKNPITILTDLRTLYCNYATAVIAAASAASK
FT KPAEHQTAASSTANHQNQNLNHQNLLQQHHSNSSSNSNCGPAAEICEPEVTIRRMFKCG
FT NSGQAEAIVNHLQMTGQQHQQLHCNVSNCSGCHMSAAAASFQLANLLNSGIRSSSTSKP
FT QRNHISASGNTSSSSNANTNNNSSGNSSLSLAAKKTSVQFHCEFCNFSCSWRYDLKLHL
FT RQKHGIHQLKKV (in isoform S)"
FT /evidence="ECO:0000305"
FT /id="VSP_017255"
FT VAR_SEQ 455..603
FT /note="DEAGQNEGGESRIRVRNWLMLADKSIIGKSSDEPSDKLTQSKKSLISDAKTT
FT NKTSTPIRPKVSTTTTSTSTAAAAAAAATIAAKQAAAAIASSNINNNNSSLTQTVTQTV
FT TRIGSIGRTTIACITPANNGNKSSSSNCNVDAASAAAL -> DSMVVPKITAVRGSSKR
FT LARRKATLAIATAMATSASATHMMSRRKRTSSSCRNASSGGNAPSTSTSASSATTASIS
FT KSKCKSSDAASAPFVCQTCGRRYQVLGTLRRHMRKECNQPKKYVCRMCERRFHYNFKLQ
FT DHYYYVHKGVQKRE (in isoform Q)"
FT /evidence="ECO:0000303|PubMed:12853139"
FT /id="VSP_051807"
FT VAR_SEQ 456..665
FT /note="EAGQNEGGESRIRVRNWLMLADKSIIGKSSDEPSDKLTQSKKSLISDAKTTN
FT KTSTPIRPKVSTTTTSTSTAAAAAAAATIAAKQAAAAIASSNINNNNSSLTQTVTQTVT
FT RIGSIGRTTIACITPANNGNKSSSSNCNVDAASAAALAAAGVELDSIDDTMTEVIVKIE
FT NPESMPLNDDEDDAVCNEAIEDENTFDYDLKLGSPLSWTY -> LRTLYCNYATAVIAA
FT ASAASKKPAEHQTAASSTANHQNQNLNHQNLLQQHHSNSSSNSNCGPAAEICEPEVTIR
FT RMFKCGNSGQAEAIVNHLQMTGQQHQQLHCNVSNCSGCHMSAAAASFQLANLLNSGIRS
FT SSTSKPQRNHISASGNTSSSSNANTNNNSSGNSSLSLAAKKTSVQFHCEFCNFSCSWRY
FT DLKLHLRQKHGIHQLKKV (in isoform Z)"
FT /evidence="ECO:0000303|PubMed:12853139"
FT /id="VSP_051808"
FT VAR_SEQ 604..963
FT /note="Missing (in isoform Q)"
FT /evidence="ECO:0000303|PubMed:12853139"
FT /id="VSP_051810"
FT VAR_SEQ 666..963
FT /note="Missing (in isoform Z)"
FT /evidence="ECO:0000303|PubMed:12853139"
FT /id="VSP_051811"
FT VAR_SEQ 721..963
FT /note="Missing (in isoform S)"
FT /evidence="ECO:0000305"
FT /id="VSP_017256"
FT VAR_SEQ 758..963
FT /note="Missing (in isoform J)"
FT /evidence="ECO:0000303|PubMed:12853139"
FT /id="VSP_051812"
FT MUTAGEN 107
FT /note="A->V: In ORE120; defective in embryonic axon
FT guidance."
FT /evidence="ECO:0000269|PubMed:11880341"
FT CONFLICT 115
FT /note="L -> F (in Ref. 4; ABJ17042)"
FT /evidence="ECO:0000305"
FT CONFLICT Q9V5M6-3:477
FT /note="A -> G (in Ref. 1; BAC67578/BAC67598/BAC67618/
FT BAC67638)"
FT /evidence="ECO:0000305"
FT CONFLICT Q9V5M6-3:485
FT /note="M -> I (in Ref. 1; BAC67578/BAC67598/BAC67618/
FT BAC67638)"
FT /evidence="ECO:0000305"
FT CONFLICT Q9V5M6-5:475
FT /note="S -> N (in Ref. 1; BAC67601/BAC67621/BAC67641)"
FT /evidence="ECO:0000305"
FT CONFLICT Q9V5M6-5:549
FT /note="M -> V (in Ref. 1; BAC67601/BAC67621/BAC67641)"
FT /evidence="ECO:0000305"
FT CONFLICT Q9V5M6-5:626
FT /note="A -> V (in Ref. 1; BAC67601/BAC67621/BAC67641)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 963 AA; 102734 MW; 850960B2AFDD577C CRC64;
MDDDQQFCLR WNNHQSTLIS VFDTLLENET LVDCTLAAEG KFLKAHKVVL SACSPYFATL
LQEQYDKHPI FILKDVKYQE LRAMMDYMYR GEVNISQDQL AALLKAAESL QIKGLSDNRT
GGGVAPKPES SGHHRGGKLS GAYTLEQTKR ARLATGGAMD TSGDVSGSRE GSSSPSRRRR
KVRRRSMEND AHDNSNSSVL QAAASNQSIL QQTGAGLAVS ALVTTQLSSG PAAGTSSQAS
STQQQQPLTS TNVTKKTESA KLTSSTAAPA SGASASAAVQ QAHLHQQQAQ TTSDAINTEN
VQAQSQGGAQ GVQGDDEDID EGSAVGGPNS ATGPNPASAS ASAVHAGVVV KQLASVVDKS
SSNHKHKIKD NSVSSVGSEM VIEPKAEYDD DAHDENVEDL TLDEEDMTME ELDQTAGTSQ
GGEGSSQTYA TWQHDRSQDE LGLMAQDAQQ RDPQDEAGQN EGGESRIRVR NWLMLADKSI
IGKSSDEPSD KLTQSKKSLI SDAKTTNKTS TPIRPKVSTT TTSTSTAAAA AAAATIAAKQ
AAAAIASSNI NNNNSSLTQT VTQTVTRIGS IGRTTIACIT PANNGNKSSS SNCNVDAASA
AALAAAGVEL DSIDDTMTEV IVKIENPESM PLNDDEDDAV CNEAIEDENT FDYDLKLGSP
LSWTYDAVKI ENEEFEDSYL MDNDDDDDDL LTTAAATQKH AKQSNEKQMA GSMVAGAGSG
GAVKKIVLSA QQQQQLLEQQ QHLQHLQLQP TSQSLQIKLP AIPATITTIS APKQMMSGAG
TSGSLTPNNN CTLMSNKLGL PVKGQNLDLH WSHSDDNRYR VLVQNKRTRK ESLEHSADMI
YNADIEKPWV CRNCNRTYKW KNSLKCHLKN ECGLPPRYFC SKMCGYATNV HSNLKRHLNT
KCRDREKDAD DEKKPGSASG NMPVVVGVGN GTAVPVSSSN NNNNGGGSST SSTYTLVFQN
DSA
