LOLA6_DROME
ID LOLA6_DROME Reviewed; 878 AA.
AC Q9V5M3; Q7KQY7; Q7KQY8; Q867I9; Q867J2; Q867U5; Q867Y0; Q86BC4;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 3.
DT 03-AUG-2022, entry version 164.
DE RecName: Full=Longitudinals lacking protein, isoforms N/O/W/X/Y;
GN Name=lola {ECO:0000312|FlyBase:FBgn0283521};
GN ORFNames=CG12052 {ECO:0000312|FlyBase:FBgn0283521};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1] {ECO:0000305, ECO:0000312|EMBL:BAC67593.1}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS O; W; X AND Y).
RC STRAIN=Canton-S {ECO:0000312|EMBL:BAC67593.1};
RX PubMed=12853139; DOI=10.1016/s0378-1119(03)00554-7;
RA Ohsako T., Horiuchi T., Matsuo T., Komaya S., Aigaki T.;
RT "Drosophila lola encodes a family of BTB-transcription regulators with
RT highly variable C-terminal domains containing zinc finger motifs.";
RL Gene 311:59-69(2003).
RN [2] {ECO:0000312|EMBL:AAF58781.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000269|PubMed:10731132};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3] {ECO:0000305, ECO:0000312|EMBL:AAF58781.3}
RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, AND DEVELOPMENTAL STAGE.
RX PubMed=8050351; DOI=10.1242/dev.120.6.1385;
RA Giniger E., Tietje K., Jan L.Y., Jan Y.N.;
RT "Lola encodes a putative transcription factor required for axon growth and
RT guidance in Drosophila.";
RL Development 120:1385-1398(1994).
RN [5] {ECO:0000305}
RP FUNCTION, AND MUTAGENESIS OF ALA-107.
RX PubMed=11880341; DOI=10.1242/dev.129.6.1317;
RA Crowner D., Madden K., Goeke S., Giniger E.;
RT "Lola regulates midline crossing of CNS axons in Drosophila.";
RL Development 129:1317-1325(2002).
RN [6]
RP TRANS-SPLICING.
RX PubMed=14522953; DOI=10.1101/gad.1137303;
RA Horiuchi T., Giniger E., Aigaki T.;
RT "Alternative trans-splicing of constant and variable exons of a Drosophila
RT axon guidance gene, lola.";
RL Genes Dev. 17:2496-2501(2003).
RN [7] {ECO:0000305}
RP DEVELOPMENTAL STAGE.
RX PubMed=12538650; DOI=10.1074/jbc.m213269200;
RA Zhang W., Wang Y., Long J., Girton J., Johansen J., Johansen K.M.;
RT "A developmentally regulated splice variant from the complex lola locus
RT encoding multiple different zinc finger domain proteins interacts with the
RT chromosomal kinase JIL-1.";
RL J. Biol. Chem. 278:11696-11704(2003).
RN [8]
RP DEVELOPMENTAL STAGE, AND TISSUE SPECIFICITY.
RX PubMed=12897787; DOI=10.1038/nn1105;
RA Goeke S., Greene E.A., Grant P.K., Gates M.A., Crowner D., Aigaki T.,
RA Giniger E.;
RT "Alternative splicing of lola generates 19 transcription factors
RT controlling axon guidance in Drosophila.";
RL Nat. Neurosci. 6:917-924(2003).
CC -!- FUNCTION: Putative transcription factor required for axon growth and
CC guidance in the central and peripheral nervous systems. Repels CNS
CC axons away from the midline by promoting the expression of the midline
CC repellent sli and its receptor robo. {ECO:0000269|PubMed:11880341,
CC ECO:0000269|PubMed:8050351}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:8050351}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=22;
CC Comment=Some isoforms may be generated by alternative trans-splicing
CC of exons sequentially encoded by the same DNA strand.;
CC Name=N {ECO:0000303|PubMed:10731132};
CC IsoId=Q9V5M3-1; Sequence=Displayed;
CC Name=O {ECO:0000269|PubMed:12853139}; Synonyms=Ohsako-P
CC {ECO:0000303|PubMed:12853139};
CC IsoId=Q9V5M3-2; Sequence=VSP_051814, VSP_051817;
CC Name=W {ECO:0000269|PubMed:12853139}; Synonyms=Ohsako-Q
CC {ECO:0000303|PubMed:12853139};
CC IsoId=Q9V5M3-3; Sequence=VSP_051818, VSP_051819;
CC Name=X {ECO:0000269|PubMed:12853139}; Synonyms=Ohsako-S
CC {ECO:0000303|PubMed:12853139};
CC IsoId=Q9V5M3-4; Sequence=VSP_051813, VSP_051816;
CC Name=Y {ECO:0000269|PubMed:12853139}; Synonyms=Ohsako-R
CC {ECO:0000303|PubMed:12853139};
CC IsoId=Q9V5M3-5; Sequence=VSP_051815;
CC Name=A {ECO:0000269|PubMed:12853139}; Synonyms=Ohsako-D
CC {ECO:0000303|PubMed:12853139};
CC IsoId=Q7KQZ4-2; Sequence=External;
CC Name=B; Synonyms=C {ECO:0000269|PubMed:12853139}, Ohsako-L
CC {ECO:0000303|PubMed:12853139};
CC IsoId=Q7KQZ4-1; Sequence=External;
CC Name=D {ECO:0000303|PubMed:10731132}; Synonyms=E, Ohsako-F
CC {ECO:0000303|PubMed:12853139};
CC IsoId=Q7KQZ4-3; Sequence=External;
CC Name=F {ECO:0000269|PubMed:12853139}; Synonyms=Ohsako-I
CC {ECO:0000303|PubMed:12853139};
CC IsoId=Q867Z4-2; Sequence=External;
CC Name=G {ECO:0000269|PubMed:12853139}; Synonyms=Long
CC {ECO:0000303|PubMed:8050351}, Ohsako-T {ECO:0000303|PubMed:12853139},
CC R;
CC IsoId=P42283-1; Sequence=External;
CC Name=H {ECO:0000269|PubMed:12853139}; Synonyms=Ohsako-M
CC {ECO:0000303|PubMed:12853139};
CC IsoId=P42284-3; Sequence=External;
CC Name=I {ECO:0000269|PubMed:12853139}; Synonyms=Ohsako-K
CC {ECO:0000303|PubMed:12853139};
CC IsoId=Q867Z4-1; Sequence=External;
CC Name=J {ECO:0000269|PubMed:12853139}; Synonyms=Ohsako-O
CC {ECO:0000303|PubMed:12853139};
CC IsoId=Q9V5M6-2; Sequence=External;
CC Name=K {ECO:0000269|PubMed:12853139}; Synonyms=Ohsako-H
CC {ECO:0000303|PubMed:12853139};
CC IsoId=Q867Z4-3; Sequence=External;
CC Name=L {ECO:0000269|PubMed:12853139}; Synonyms=Ohsako-C
CC {ECO:0000303|PubMed:12853139};
CC IsoId=Q7KQZ4-4; Sequence=External;
CC Name=M {ECO:0000269|PubMed:12853139}; Synonyms=Short
CC {ECO:0000303|PubMed:8050351}, Ohsako-A {ECO:0000303|PubMed:12853139};
CC IsoId=P42284-1; Sequence=External;
CC Name=P {ECO:0000269|PubMed:12853139}; Synonyms=Ohsako-N
CC {ECO:0000303|PubMed:12853139};
CC IsoId=Q9V5M6-1; Sequence=External;
CC Name=Q {ECO:0000269|PubMed:12853139}; Synonyms=Ohsako-B
CC {ECO:0000303|PubMed:12853139};
CC IsoId=Q9V5M6-3; Sequence=External;
CC Name=S {ECO:0000269|PubMed:12853139};
CC IsoId=Q9V5M6-4; Sequence=External;
CC Name=T {ECO:0000269|PubMed:12853139}; Synonyms=U
CC {ECO:0000303|PubMed:10731132}, Ohsako-J {ECO:0000303|PubMed:12853139};
CC IsoId=Q867Z4-5; Sequence=External;
CC Name=V {ECO:0000269|PubMed:12853139}; Synonyms=Ohsako-G
CC {ECO:0000303|PubMed:12853139};
CC IsoId=P42284-2; Sequence=External;
CC Name=Z; Synonyms=Ohsako-E;
CC IsoId=Q9V5M6-5; Sequence=External;
CC -!- TISSUE SPECIFICITY: By stage 11, isoform W, isoform X and isoform Y are
CC expressed throughout the mesoderm, whereas isoform O is expressed in
CC both mesoderm and ectoderm. From stage 15, expression of isoform O
CC expands to all tissues, whereas expression of isoform W, isoform X and
CC isoform Y becomes restricted during later stages; starting from stage
CC 14 to 16, isoform W, isoform X and isoform Y are expressed in muscle.
CC From stages 14 and 15, isoform W and isoform Y are expressed in the
CC gut. For some isoforms, expression is also seen in specific types of
CC cells in the embryo; isoform O is expressed in the ventral furrow at
CC stage 5 and in the dorsal epidermis from stage 7. Isoform Y shows
CC prominent expression in the gonad starting at stage 15.
CC {ECO:0000269|PubMed:12897787}.
CC -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically. At
CC least one isoform is present at each developmental stage.
CC {ECO:0000269|PubMed:12538650, ECO:0000269|PubMed:12897787,
CC ECO:0000269|PubMed:8050351}.
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DR EMBL; AB107287; BAC67592.1; -; mRNA.
DR EMBL; AB107288; BAC67593.1; -; mRNA.
DR EMBL; AB107289; BAC67594.1; -; mRNA.
DR EMBL; AB107290; BAC67595.1; -; mRNA.
DR EMBL; AB107307; BAC67612.1; -; mRNA.
DR EMBL; AB107308; BAC67613.1; -; mRNA.
DR EMBL; AB107309; BAC67614.1; -; mRNA.
DR EMBL; AB107310; BAC67615.1; -; mRNA.
DR EMBL; AB107327; BAC67632.1; -; mRNA.
DR EMBL; AB107328; BAC67633.1; -; mRNA.
DR EMBL; AB107329; BAC67634.1; -; mRNA.
DR EMBL; AB107330; BAC67635.1; -; mRNA.
DR EMBL; AB107347; BAC67652.1; -; mRNA.
DR EMBL; AB107348; BAC67653.1; -; mRNA.
DR EMBL; AB107349; BAC67654.1; -; mRNA.
DR EMBL; AB107350; BAC67655.1; -; mRNA.
DR EMBL; AE013599; AAF58781.3; -; Genomic_DNA.
DR EMBL; AE013599; AAO41424.2; -; Genomic_DNA.
DR EMBL; AE013599; AAS64874.1; -; Genomic_DNA.
DR EMBL; AE013599; AAS64875.1; -; Genomic_DNA.
DR EMBL; AE013599; AAS64876.1; -; Genomic_DNA.
DR RefSeq; NP_788308.3; NM_176128.5.
DR RefSeq; NP_788309.2; NM_176129.5. [Q9V5M3-2]
DR RefSeq; NP_788313.1; NM_176133.5.
DR RefSeq; NP_995804.1; NM_206082.4. [Q9V5M3-5]
DR RefSeq; NP_995805.1; NM_206083.4. [Q9V5M3-4]
DR RefSeq; NP_995806.1; NM_206084.4. [Q9V5M3-3]
DR AlphaFoldDB; Q9V5M3; -.
DR BioGRID; 69126; 52.
DR IntAct; Q9V5M3; 2.
DR DNASU; 44548; -.
DR EnsemblMetazoa; FBtr0089361; FBpp0088395; FBgn0283521. [Q9V5M3-2]
DR EnsemblMetazoa; FBtr0089364; FBpp0088950; FBgn0283521. [Q9V5M3-3]
DR EnsemblMetazoa; FBtr0089365; FBpp0088951; FBgn0283521. [Q9V5M3-4]
DR EnsemblMetazoa; FBtr0089366; FBpp0088948; FBgn0283521. [Q9V5M3-5]
DR GeneID; 44548; -.
DR CTD; 44548; -.
DR FlyBase; FBgn0283521; lola.
DR VEuPathDB; VectorBase:FBgn0283521; -.
DR GeneTree; ENSGT00940000174551; -.
DR HOGENOM; CLU_010740_5_0_1; -.
DR SignaLink; Q9V5M3; -.
DR BioGRID-ORCS; 44548; 1 hit in 1 CRISPR screen.
DR ChiTaRS; lola; fly.
DR GenomeRNAi; 44548; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0283521; Expressed in cleaving embryo and 52 other tissues.
DR ExpressionAtlas; Q9V5M3; baseline and differential.
DR Genevisible; Q9V5M3; DM.
DR GO; GO:0005654; C:nucleoplasm; HDA:FlyBase.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:FlyBase.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007411; P:axon guidance; IMP:UniProtKB.
DR GO; GO:0016199; P:axon midline choice point recognition; IMP:UniProtKB.
DR GO; GO:0007409; P:axonogenesis; IMP:UniProtKB.
DR GO; GO:0048813; P:dendrite morphogenesis; IMP:FlyBase.
DR GO; GO:0008406; P:gonad development; IMP:FlyBase.
DR GO; GO:0035167; P:larval lymph gland hemopoiesis; IMP:FlyBase.
DR GO; GO:0007526; P:larval somatic muscle development; IMP:FlyBase.
DR GO; GO:0045476; P:nurse cell apoptotic process; IMP:FlyBase.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0007464; P:R3/R4 cell fate commitment; IMP:FlyBase.
DR GO; GO:0045467; P:R7 cell development; IMP:FlyBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:FlyBase.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00651; BTB; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00355; ZnF_C2H2; 2.
DR SUPFAM; SSF54695; SSF54695; 1.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Developmental protein; Differentiation;
KW DNA-binding; Metal-binding; Neurogenesis; Nucleus; Reference proteome;
KW Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..878
FT /note="Longitudinals lacking protein, isoforms N/O/W/X/Y"
FT /id="PRO_0000047077"
FT DOMAIN 32..97
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT ZN_FING 709..731
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 794..816
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 115..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 228..340
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 542..583
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 826..863
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 228..311
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 827..863
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 455..668
FT /note="DGYWTILETVPYSIASAAPNQTLTTATTLSNGGSSLLTGATVVVELPPDDLG
FT NPVGNIQYTIPALTKNATTNTNTTSLLHKPQATTIQIVKQQHQQQHQQQHQHPQQQHQP
FT QQQQHRQHLTIQQSQTHARQEYIKIDTSRLEDKMLLRDVMQYGATSIAMAPQSATTTVV
FT STHPVESGLLLADADEAERELELEAMKVDQHDEEHLLDDEGYVI -> DIYPILGSLLG
FT VDTSTSANPGSSANASDEFYGYHLNNNNTTTSSSTTISHAKNTSNSGAFSSGGGGGGGL
FT SRDSFMQCKHCNRYYKSHQKLQEHVRKYCLKQKKYKCVSCEYRSRRKDHVLRHAKRKHC
FT MLYEQSRDDEESLYVIRNEDDMSNDEEAVDGDDGDPEDGDPGGMDDVAAALCEINFDFA
FT GRDLTITAVPALQESEEDDEDYDDDG (in isoform O)"
FT /evidence="ECO:0000303|PubMed:12853139"
FT /id="VSP_051814"
FT VAR_SEQ 455..602
FT /note="DGYWTILETVPYSIASAAPNQTLTTATTLSNGGSSLLTGATVVVELPPDDLG
FT NPVGNIQYTIPALTKNATTNTNTTSLLHKPQATTIQIVKQQHQQQHQQQHQHPQQQHQP
FT QQQQHRQHLTIQQSQTHARQEYIKIDTSRLEDKMLLR -> VITVDRKYNLRTQESSGS
FT SADLPSTSKQKVAAVQHKLAELASLDQKSENEEPTDLDNAASLKKAMATSDAMIALQQL
FT ASISTARSLQHLVQNMSNIDNSALVPGRKLPRNAAKRSPKYESNRCPLCSRVCRSQAFL
FT NEHMRKEHSVLI (in isoform X)"
FT /evidence="ECO:0000303|PubMed:12853139"
FT /id="VSP_051813"
FT VAR_SEQ 456..756
FT /note="Missing (in isoform Y)"
FT /evidence="ECO:0000303|PubMed:12853139"
FT /id="VSP_051815"
FT VAR_SEQ 603..878
FT /note="Missing (in isoform X)"
FT /evidence="ECO:0000303|PubMed:12853139"
FT /id="VSP_051816"
FT VAR_SEQ 669..878
FT /note="Missing (in isoform O)"
FT /evidence="ECO:0000303|PubMed:12853139"
FT /id="VSP_051817"
FT VAR_SEQ 749..771
FT /note="CVLAQVVNFVRHGPKNQLLCQCG -> YRSDLRKHMNQKHADSGEAILAT
FT (in isoform W)"
FT /evidence="ECO:0000303|PubMed:12853139"
FT /id="VSP_051818"
FT VAR_SEQ 772..878
FT /note="Missing (in isoform W)"
FT /evidence="ECO:0000303|PubMed:12853139"
FT /id="VSP_051819"
FT MUTAGEN 107
FT /note="A->V: In ORE120; defective in embryonic axon
FT guidance."
FT /evidence="ECO:0000269|PubMed:11880341"
FT CONFLICT 786
FT /note="E -> D (in Ref. 1; BAC67594/BAC67614/BAC67634/
FT BAC67654)"
FT /evidence="ECO:0000305"
FT CONFLICT Q9V5M3-4:587
FT /note="Q -> P (in Ref. 1; BAC67595/BAC67615/BAC67635/
FT BAC67655)"
FT /evidence="ECO:0000305"
FT CONFLICT Q9V5M3-5:485
FT /note="E -> D (in Ref. 1; BAC67594/BAC67614/BAC67634/
FT BAC67654)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 878 AA; 96207 MW; 39F4202612B246BD CRC64;
MDDDQQFCLR WNNHQSTLIS VFDTLLENET LVDCTLAAEG KFLKAHKVVL SACSPYFATL
LQEQYDKHPI FILKDVKYQE LRAMMDYMYR GEVNISQDQL AALLKAAESL QIKGLSDNRT
GGGVAPKPES SGHHRGGKLS GAYTLEQTKR ARLATGGAMD TSGDVSGSRE GSSSPSRRRR
KVRRRSMEND AHDNSNSSVL QAAASNQSIL QQTGAGLAVS ALVTTQLSSG PAAGTSSQAS
STQQQQPLTS TNVTKKTESA KLTSSTAAPA SGASASAAVQ QAHLHQQQAQ TTSDAINTEN
VQAQSQGGAQ GVQGDDEDID EGSAVGGPNS ATGPNPASAS ASAVHAGVVV KQLASVVDKS
SSNHKHKIKD NSVSSVGSEM VIEPKAEYDD DAHDENVEDL TLDEEDMTME ELDQTAGTSQ
GGEGSSQTYA TWQHDRSQDE LGLMAQDAQQ RDPQDGYWTI LETVPYSIAS AAPNQTLTTA
TTLSNGGSSL LTGATVVVEL PPDDLGNPVG NIQYTIPALT KNATTNTNTT SLLHKPQATT
IQIVKQQHQQ QHQQQHQHPQ QQHQPQQQQH RQHLTIQQSQ THARQEYIKI DTSRLEDKML
LRDVMQYGAT SIAMAPQSAT TTVVSTHPVE SGLLLADADE AERELELEAM KVDQHDEEHL
LDDEGYVIEK IHGDGETVNQ PQEKLYINGM SNIIHTATTM TLQPDDCKYA CNVCGKTYKI
KGSLKRHKNY ECGVEPNLKC PHCPHKCKCV LAQVVNFVRH GPKNQLLCQC GRYYNTLSRL
MLHQREECQD FKRFQCDFCL KWFKRRSHLN RHKKLHDAEL FLEPLSKQKP KTTSGQNLSH
DANTDDEVAT TNPAATEDES NYPFTSEIKI ENEFDEFI
