LOLAL_DROME
ID LOLAL_DROME Reviewed; 127 AA.
AC Q7KRI2; A4UZN1; B7YZR8; C7LAH2;
DT 16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Longitudinals lacking protein-like;
DE Short=Lola-like protein;
DE AltName: Full=Protein Batman;
GN Name=lolal {ECO:0000312|EMBL:AAM68179.1};
GN Synonyms=ban {ECO:0000303|PubMed:12556479}; ORFNames=CG5738;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1] {ECO:0000312|EMBL:AAG45054.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11370860; DOI=10.1007/s004380000391;
RA Faucheux M., Netter S., Bloyer S., Moussa M., Boissonneau E., Lemeunier F.,
RA Wegnez M., Theodore L.;
RT "Advantages of a P-element construct containing MtnA sequences for the
RT identification of patterning and cell determination genes in Drosophila
RT melanogaster.";
RL Mol. Genet. Genomics 265:14-22(2001).
RN [2] {ECO:0000312|EMBL:AAM68179.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000269|PubMed:10731132};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3] {ECO:0000305, ECO:0000312|EMBL:AAM68179.1}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4] {ECO:0000312|EMBL:AAL25403.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley {ECO:0000312|EMBL:AAL25403.1};
RC TISSUE=Embryo {ECO:0000269|PubMed:12537569};
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley;
RA Carlson J.W., Booth B., Frise E., Sandler J., Wan K.H., Yu C.,
RA Celniker S.E.;
RL Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000305}
RP FUNCTION, INTERACTION WITH TRL, AND IDENTIFICATION IN A COMPLEX WITH PC.
RX PubMed=12834867; DOI=10.1016/s0925-4773(03)00046-7;
RA Mishra K., Chopra V.S., Srinivasan A., Mishra R.K.;
RT "Trl-GAGA directly interacts with lola like and both are part of the
RT repressive complex of Polycomb group of genes.";
RL Mech. Dev. 120:681-689(2003).
RN [7] {ECO:0000305}
RP FUNCTION, INTERACTION WITH TRL, AND SUBCELLULAR LOCATION.
RX PubMed=12556479; DOI=10.1128/mcb.23.4.1181-1195.2003;
RA Faucheux M., Roignant J.-Y., Netter S., Charollais J., Antoniewski C.,
RA Theodore L.;
RT "Batman interacts with polycomb and trithorax group genes and encodes a
RT BTB/POZ protein that is included in a complex containing GAGA factor.";
RL Mol. Cell. Biol. 23:1181-1195(2003).
CC -!- FUNCTION: Required, together with Trl, for maintaining the repressed
CC state of target genes including homeotic genes Scr and Ubx. May also be
CC involved in the activation of homeotic genes. Binds to a DNA Polycomb
CC response element (PRE) at the bithorax complex. Also binds to polytene
CC chromosomes at several hundred sites, many of which are shared with Trl
CC and ph-p. Required during embryonic development.
CC {ECO:0000269|PubMed:12556479, ECO:0000269|PubMed:12834867}.
CC -!- SUBUNIT: The BTB domain interacts with the BTB domain of Trl in vitro.
CC Found in a Pc-containing complex. {ECO:0000269|PubMed:12556479,
CC ECO:0000269|PubMed:12834867}.
CC -!- INTERACTION:
CC Q7KRI2; Q08605: Trl; NbExp=6; IntAct=EBI-84493, EBI-300317;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12556479}.
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DR EMBL; AF308476; AAG45054.1; -; mRNA.
DR EMBL; AE013599; AAF57739.1; -; Genomic_DNA.
DR EMBL; AE013599; AAM68179.1; -; Genomic_DNA.
DR EMBL; AE013599; AAM68180.1; -; Genomic_DNA.
DR EMBL; AE013599; AAM68181.1; -; Genomic_DNA.
DR EMBL; AY060364; AAL25403.1; -; mRNA.
DR EMBL; BT099722; ACV53086.1; -; mRNA.
DR RefSeq; NP_001163186.1; NM_001169715.2.
DR RefSeq; NP_001246402.1; NM_001259473.2.
DR RefSeq; NP_001246403.1; NM_001259474.2.
DR RefSeq; NP_001286564.1; NM_001299635.1.
DR RefSeq; NP_524778.1; NM_080039.4.
DR RefSeq; NP_725756.1; NM_166270.2.
DR RefSeq; NP_725757.1; NM_166271.3.
DR RefSeq; NP_725758.1; NM_166272.3.
DR AlphaFoldDB; Q7KRI2; -.
DR SMR; Q7KRI2; -.
DR BioGRID; 69215; 23.
DR IntAct; Q7KRI2; 7.
DR STRING; 7227.FBpp0085955; -.
DR PaxDb; Q7KRI2; -.
DR PRIDE; Q7KRI2; -.
DR EnsemblMetazoa; FBtr0086776; FBpp0085955; FBgn0022238.
DR EnsemblMetazoa; FBtr0086777; FBpp0085956; FBgn0022238.
DR EnsemblMetazoa; FBtr0086778; FBpp0085957; FBgn0022238.
DR EnsemblMetazoa; FBtr0086779; FBpp0085958; FBgn0022238.
DR EnsemblMetazoa; FBtr0300483; FBpp0289710; FBgn0022238.
DR EnsemblMetazoa; FBtr0300484; FBpp0289711; FBgn0022238.
DR EnsemblMetazoa; FBtr0305270; FBpp0293794; FBgn0022238.
DR EnsemblMetazoa; FBtr0345357; FBpp0311512; FBgn0022238.
DR GeneID; 44703; -.
DR KEGG; dme:Dmel_CG5738; -.
DR CTD; 44703; -.
DR FlyBase; FBgn0022238; lolal.
DR VEuPathDB; VectorBase:FBgn0022238; -.
DR eggNOG; ENOG502RY9Q; Eukaryota.
DR GeneTree; ENSGT00530000064321; -.
DR HOGENOM; CLU_004253_8_1_1; -.
DR InParanoid; Q7KRI2; -.
DR OMA; DVPFQHL; -.
DR OrthoDB; 1229475at2759; -.
DR PhylomeDB; Q7KRI2; -.
DR BioGRID-ORCS; 44703; 0 hits in 1 CRISPR screen.
DR ChiTaRS; lolal; fly.
DR GenomeRNAi; 44703; -.
DR PRO; PR:Q7KRI2; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0022238; Expressed in cleaving embryo and 46 other tissues.
DR ExpressionAtlas; Q7KRI2; baseline and differential.
DR Genevisible; Q7KRI2; DM.
DR GO; GO:0000794; C:condensed nuclear chromosome; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0031519; C:PcG protein complex; IPI:UniProtKB.
DR GO; GO:0005700; C:polytene chromosome; IDA:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IDA:FlyBase.
DR GO; GO:0031208; F:POZ domain binding; IDA:FlyBase.
DR GO; GO:0042803; F:protein homodimerization activity; IDA:FlyBase.
DR GO; GO:0009953; P:dorsal/ventral pattern formation; IMP:FlyBase.
DR GO; GO:0001700; P:embryonic development via the syncytial blastoderm; IMP:UniProtKB.
DR GO; GO:0031507; P:heterochromatin assembly; IMP:FlyBase.
DR GO; GO:0035167; P:larval lymph gland hemopoiesis; IMP:FlyBase.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:FlyBase.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IGI:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0007435; P:salivary gland morphogenesis; IMP:FlyBase.
DR GO; GO:0007426; P:tracheal outgrowth, open tracheal system; IMP:FlyBase.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR Pfam; PF00651; BTB; 1.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50097; BTB; 1.
PE 1: Evidence at protein level;
KW Activator; Chromatin regulator; Developmental protein; DNA-binding;
KW Nucleus; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..127
FT /note="Longitudinals lacking protein-like"
FT /id="PRO_0000186221"
FT DOMAIN 33..98
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
SQ SEQUENCE 127 AA; 14489 MW; 3D5DE2C4E2E06B2D CRC64;
MMSSDQQFFL KWNDFQTNMV TSFRHLRDEK SFTDVTLACE GQTCKAHKMV LSACSPYFKA
LLEENPSKHP IIILKDVSYI HLQAILEFMY AGEVNVSQEQ LPAFLKTADR LKVKGLAETP
SSIKREG
