ID   LOLA_HELPY              Reviewed;         184 AA.
AC   O25474;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 105.
DE   RecName: Full=Outer-membrane lipoprotein carrier protein;
DE   Flags: Precursor;
GN   Name=lolA; OrderedLocusNames=HP_0785;
OS   Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85962;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700392 / 26695;
RX   PubMed=9252185; DOI=10.1038/41483;
RA   Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA   Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA   Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA   Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA   McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA   Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA   Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA   Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT   "The complete genome sequence of the gastric pathogen Helicobacter
RT   pylori.";
RL   Nature 388:539-547(1997).
CC   -!- FUNCTION: Participates in the translocation of lipoproteins from the
CC       inner membrane to the outer membrane. Only forms a complex with a
CC       lipoprotein if the residue after the N-terminal Cys is not an aspartate
CC       (The Asp acts as a targeting signal to indicate that the lipoprotein
CC       should stay in the inner membrane) (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LolA family. {ECO:0000305}.
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DR   EMBL; AE000511; AAD07829.1; -; Genomic_DNA.
DR   PIR; A64618; A64618.
DR   RefSeq; NP_207578.1; NC_000915.1.
DR   RefSeq; WP_001201065.1; NC_018939.1.
DR   AlphaFoldDB; O25474; -.
DR   SMR; O25474; -.
DR   DIP; DIP-3763N; -.
DR   IntAct; O25474; 1.
DR   MINT; O25474; -.
DR   STRING; 85962.C694_04025; -.
DR   PaxDb; O25474; -.
DR   EnsemblBacteria; AAD07829; AAD07829; HP_0785.
DR   KEGG; hpy:HP_0785; -.
DR   PATRIC; fig|85962.47.peg.837; -.
DR   eggNOG; COG2834; Bacteria.
DR   OMA; IYMNDKE; -.
DR   Proteomes; UP000000429; Chromosome.
DR   GO; GO:0030288; C:outer membrane-bounded periplasmic space; IBA:GO_Central.
DR   GO; GO:0044874; P:lipoprotein localization to outer membrane; IBA:GO_Central.
DR   GO; GO:0042953; P:lipoprotein transport; IEA:InterPro.
DR   CDD; cd16325; LolA; 1.
DR   HAMAP; MF_00240; LolA; 1.
DR   InterPro; IPR029046; LolA/LolB/LppX.
DR   InterPro; IPR004564; OM_lipoprot_carrier_LolA-like.
DR   InterPro; IPR018323; OM_lipoprot_carrier_LolA_Pbac.
DR   PANTHER; PTHR35869; PTHR35869; 1.
DR   Pfam; PF03548; LolA; 1.
DR   SUPFAM; SSF89392; SSF89392; 1.
PE   3: Inferred from homology;
KW   Chaperone; Periplasm; Protein transport; Reference proteome; Signal;
KW   Transport.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..184
FT                   /note="Outer-membrane lipoprotein carrier protein"
FT                   /id="PRO_0000018262"
SQ   SEQUENCE   184 AA;  21481 MW;  B0DC655A9C06D656 CRC64;
     MRAFLKILMV LIFMSVAYAK NPSTLSKEEE VLQHLQSFSA HFKQVLKNEK PLVYYGVLKA
     KAPNWALWVY EKPLKKEIYM NDKEVVIYEP NLFQATITPL KDKTDFFTIL KRLKKQDDGS
     FKTTINKTTY RLVFKDGKPF SLEFKDGMNN LVTITFSQAE INPTIANEIF VFKPKDENID
     IVRQ