LOLA_LEGPA
ID LOLA_LEGPA Reviewed; 202 AA.
AC Q5X4E7;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 25-MAY-2022, entry version 85.
DE RecName: Full=Outer-membrane lipoprotein carrier protein {ECO:0000255|HAMAP-Rule:MF_00240};
DE Flags: Precursor;
GN Name=lolA {ECO:0000255|HAMAP-Rule:MF_00240}; OrderedLocusNames=lpp1729;
OS Legionella pneumophila (strain Paris).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Legionellales;
OC Legionellaceae; Legionella.
OX NCBI_TaxID=297246;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Paris;
RX PubMed=15467720; DOI=10.1038/ng1447;
RA Cazalet C., Rusniok C., Brueggemann H., Zidane N., Magnier A., Ma L.,
RA Tichit M., Jarraud S., Bouchier C., Vandenesch F., Kunst F., Etienne J.,
RA Glaser P., Buchrieser C.;
RT "Evidence in the Legionella pneumophila genome for exploitation of host
RT cell functions and high genome plasticity.";
RL Nat. Genet. 36:1165-1173(2004).
CC -!- FUNCTION: Participates in the translocation of lipoproteins from the
CC inner membrane to the outer membrane. Only forms a complex with a
CC lipoprotein if the residue after the N-terminal Cys is not an aspartate
CC (The Asp acts as a targeting signal to indicate that the lipoprotein
CC should stay in the inner membrane). {ECO:0000255|HAMAP-Rule:MF_00240}.
CC -!- SUBUNIT: Monomer. {ECO:0000255|HAMAP-Rule:MF_00240}.
CC -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000255|HAMAP-Rule:MF_00240}.
CC -!- SIMILARITY: Belongs to the LolA family. {ECO:0000255|HAMAP-
CC Rule:MF_00240}.
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DR EMBL; CR628336; CAH12881.1; -; Genomic_DNA.
DR RefSeq; WP_011214029.1; NC_006368.1.
DR AlphaFoldDB; Q5X4E7; -.
DR SMR; Q5X4E7; -.
DR KEGG; lpp:lpp1729; -.
DR LegioList; lpp1729; -.
DR HOGENOM; CLU_087560_0_0_6; -.
DR OMA; YDPFVEQ; -.
DR GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR GO; GO:0044874; P:lipoprotein localization to outer membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0042953; P:lipoprotein transport; IEA:InterPro.
DR CDD; cd16325; LolA; 1.
DR HAMAP; MF_00240; LolA; 1.
DR InterPro; IPR029046; LolA/LolB/LppX.
DR InterPro; IPR004564; OM_lipoprot_carrier_LolA-like.
DR InterPro; IPR018323; OM_lipoprot_carrier_LolA_Pbac.
DR PANTHER; PTHR35869; PTHR35869; 1.
DR Pfam; PF03548; LolA; 1.
DR SUPFAM; SSF89392; SSF89392; 1.
DR TIGRFAMs; TIGR00547; lolA; 1.
PE 3: Inferred from homology;
KW Chaperone; Periplasm; Protein transport; Signal; Transport.
FT SIGNAL 1..18
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00240"
FT CHAIN 19..202
FT /note="Outer-membrane lipoprotein carrier protein"
FT /id="PRO_1000071830"
SQ SEQUENCE 202 AA; 22802 MW; D78FD1BD8AEB6323 CRC64;
MNKLFLILLL IFSHEVFSQT SAEVLQSKLN AIQTMTANFS QIVKAKNHEV SRSSGSMALQ
RPGRFRWQTK DPLEQLIVAD GQKMWIYDVD LEQVTVKNQE KGLGGTAALF LSGYDETLTH
DFDVSEKQKG KLTVFDLKSK SAKENFQRIK LIFSQSALIG LELYDQLGQI TDVKLVQIKS
NPKLPAKLFQ FKPPKGVDVV KQ