LOLA_PSEAE
ID LOLA_PSEAE Reviewed; 208 AA.
AC Q9I0M4;
DT 11-JUL-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Outer-membrane lipoprotein carrier protein {ECO:0000255|HAMAP-Rule:MF_00240};
DE Flags: Precursor;
GN Name=lolA {ECO:0000255|HAMAP-Rule:MF_00240}; OrderedLocusNames=PA2614;
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
CC -!- FUNCTION: Participates in the translocation of lipoproteins from the
CC inner membrane to the outer membrane. Only forms a complex with a
CC lipoprotein if the residue after the N-terminal Cys is not an aspartate
CC (The Asp acts as a targeting signal to indicate that the lipoprotein
CC should stay in the inner membrane). {ECO:0000255|HAMAP-Rule:MF_00240}.
CC -!- SUBUNIT: Monomer. {ECO:0000255|HAMAP-Rule:MF_00240}.
CC -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000255|HAMAP-Rule:MF_00240}.
CC -!- SIMILARITY: Belongs to the LolA family. {ECO:0000255|HAMAP-
CC Rule:MF_00240}.
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DR EMBL; AE004091; AAG06002.1; -; Genomic_DNA.
DR PIR; D83318; D83318.
DR RefSeq; NP_251304.1; NC_002516.2.
DR RefSeq; WP_003090414.1; NZ_QZGE01000008.1.
DR PDB; 2W7Q; X-ray; 1.88 A; A/B=22-208.
DR PDBsum; 2W7Q; -.
DR AlphaFoldDB; Q9I0M4; -.
DR SMR; Q9I0M4; -.
DR STRING; 287.DR97_5348; -.
DR PaxDb; Q9I0M4; -.
DR PRIDE; Q9I0M4; -.
DR DNASU; 882320; -.
DR EnsemblBacteria; AAG06002; AAG06002; PA2614.
DR GeneID; 882320; -.
DR KEGG; pae:PA2614; -.
DR PATRIC; fig|208964.12.peg.2735; -.
DR PseudoCAP; PA2614; -.
DR HOGENOM; CLU_087560_0_0_6; -.
DR InParanoid; Q9I0M4; -.
DR OMA; YDPFVEQ; -.
DR PhylomeDB; Q9I0M4; -.
DR BioCyc; PAER208964:G1FZ6-2654-MON; -.
DR EvolutionaryTrace; Q9I0M4; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0030288; C:outer membrane-bounded periplasmic space; IBA:GO_Central.
DR GO; GO:0044874; P:lipoprotein localization to outer membrane; IDA:CACAO.
DR GO; GO:0042953; P:lipoprotein transport; IEA:InterPro.
DR CDD; cd16325; LolA; 1.
DR HAMAP; MF_00240; LolA; 1.
DR InterPro; IPR029046; LolA/LolB/LppX.
DR InterPro; IPR004564; OM_lipoprot_carrier_LolA-like.
DR InterPro; IPR018323; OM_lipoprot_carrier_LolA_Pbac.
DR PANTHER; PTHR35869; PTHR35869; 1.
DR Pfam; PF03548; LolA; 1.
DR SUPFAM; SSF89392; SSF89392; 1.
DR TIGRFAMs; TIGR00547; lolA; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Chaperone; Periplasm; Protein transport; Reference proteome;
KW Signal; Transport.
FT SIGNAL 1..21
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00240"
FT CHAIN 22..208
FT /note="Outer-membrane lipoprotein carrier protein"
FT /id="PRO_0000018269"
FT HELIX 24..35
FT /evidence="ECO:0007829|PDB:2W7Q"
FT STRAND 38..49
FT /evidence="ECO:0007829|PDB:2W7Q"
FT STRAND 56..66
FT /evidence="ECO:0007829|PDB:2W7Q"
FT TURN 67..69
FT /evidence="ECO:0007829|PDB:2W7Q"
FT STRAND 70..75
FT /evidence="ECO:0007829|PDB:2W7Q"
FT STRAND 77..79
FT /evidence="ECO:0007829|PDB:2W7Q"
FT STRAND 81..86
FT /evidence="ECO:0007829|PDB:2W7Q"
FT STRAND 89..94
FT /evidence="ECO:0007829|PDB:2W7Q"
FT TURN 95..98
FT /evidence="ECO:0007829|PDB:2W7Q"
FT STRAND 99..103
FT /evidence="ECO:0007829|PDB:2W7Q"
FT HELIX 105..108
FT /evidence="ECO:0007829|PDB:2W7Q"
FT TURN 109..111
FT /evidence="ECO:0007829|PDB:2W7Q"
FT HELIX 113..118
FT /evidence="ECO:0007829|PDB:2W7Q"
FT HELIX 121..124
FT /evidence="ECO:0007829|PDB:2W7Q"
FT TURN 125..127
FT /evidence="ECO:0007829|PDB:2W7Q"
FT STRAND 128..135
FT /evidence="ECO:0007829|PDB:2W7Q"
FT STRAND 138..148
FT /evidence="ECO:0007829|PDB:2W7Q"
FT STRAND 153..160
FT /evidence="ECO:0007829|PDB:2W7Q"
FT STRAND 163..170
FT /evidence="ECO:0007829|PDB:2W7Q"
FT STRAND 176..187
FT /evidence="ECO:0007829|PDB:2W7Q"
FT HELIX 192..195
FT /evidence="ECO:0007829|PDB:2W7Q"
FT STRAND 204..206
FT /evidence="ECO:0007829|PDB:2W7Q"
SQ SEQUENCE 208 AA; 23072 MW; F2382C97FA8F83A6 CRC64;
MRLIRTLFVA ALAMGASLAH ADDSAAVQRL TGLLNKAQTL TARFSQLTLD GSGTRLQETA
GQLSLKRPGL FRWHTDAPNE QLLISNGEKV WLYDPDLEQV TIQKLDQRLT QTPALLLSGD
ISKISESFAI TYKEGGNVVD FVLKPKTKDT LFDTLRLSFR SGKVNDMQMI DGVGQRTNIL
FFDVKMNEAL DAKQFTFDVP PGVDVIQE
