5HT2B_CAVPO
ID 5HT2B_CAVPO Reviewed; 96 AA.
AC P97267;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=5-hydroxytryptamine receptor 2B;
DE Short=5-HT-2B;
DE Short=5-HT2B;
DE AltName: Full=Serotonin receptor 2B;
DE Flags: Fragment;
GN Name=HTR2B;
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Dunkin-Hartley; TISSUE=Superior cervical ganglion;
RX PubMed=9116207; DOI=10.1097/00001756-199611250-00020;
RA Newberry N.R., Watkins C.J., Volenec A., Flanigan T.P.;
RT "5-HT2B receptor mRNA in guinea pig superior cervical ganglion.";
RL NeuroReport 7:2909-2911(1996).
CC -!- FUNCTION: G-protein coupled receptor for 5-hydroxytryptamine
CC (serotonin). Also functions as a receptor for various ergot alkaloid
CC derivatives and psychoactive substances. Ligand binding causes a
CC conformation change that triggers signaling via guanine nucleotide-
CC binding proteins (G proteins) and modulates the activity of down-stream
CC effectors. Beta-arrestin family members inhibit signaling via G
CC proteins and mediate activation of alternative signaling pathways.
CC Signaling activates a phosphatidylinositol-calcium second messenger
CC system that modulates the activity of phosphatidylinositol 3-kinase and
CC down-stream signaling cascades and promotes the release of Ca(2+) ions
CC from intracellular stores. Plays a role in the regulation of dopamine
CC and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the
CC regulation of extracellular dopamine and 5-hydroxytryptamine levels,
CC and thereby affects neural activity. May play a role in the perception
CC of pain. Plays a role in the regulation of behavior, including
CC impulsive behavior. Required for normal proliferation of embryonic
CC cardiac myocytes and normal heart development. Protects cardiomyocytes
CC against apoptosis. Plays a role in the adaptation of pulmonary arteries
CC to chronic hypoxia. Plays a role in vasoconstriction. Required for
CC normal osteoblast function and proliferation, and for maintaining
CC normal bone density. Required for normal proliferation of the
CC interstitial cells of Cajal in the intestine (By similarity).
CC {ECO:0000250|UniProtKB:P41595, ECO:0000250|UniProtKB:Q02152}.
CC -!- SUBUNIT: Interacts (via C-terminus) with MPDZ.
CC {ECO:0000250|UniProtKB:P41595}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P41595};
CC Multi-pass membrane protein {ECO:0000250|UniProtKB:P41595}. Synapse,
CC synaptosome {ECO:0000250|UniProtKB:Q02152}.
CC -!- DOMAIN: Ligands are bound in a hydrophobic pocket formed by the
CC transmembrane helices. {ECO:0000250|UniProtKB:P41595}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000305}.
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DR EMBL; U69635; AAB36680.1; -; mRNA.
DR AlphaFoldDB; P97267; -.
DR SMR; P97267; -.
DR STRING; 10141.ENSCPOP00000000383; -.
DR eggNOG; KOG3656; Eukaryota.
DR HOGENOM; CLU_009579_11_3_1; -.
DR InParanoid; P97267; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043005; C:neuron projection; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
DR GO; GO:0004993; F:G protein-coupled serotonin receptor activity; IEA:InterPro.
DR GO; GO:0007610; P:behavior; IEA:UniProtKB-KW.
DR GO; GO:0007507; P:heart development; IEA:InterPro.
DR GO; GO:0050795; P:regulation of behavior; IEA:InterPro.
DR GO; GO:0006939; P:smooth muscle contraction; IEA:InterPro.
DR GO; GO:0042310; P:vasoconstriction; IEA:InterPro.
DR InterPro; IPR000482; 5HT2B_rcpt.
DR PANTHER; PTHR24247:SF31; PTHR24247:SF31; 1.
DR PRINTS; PR00651; 5HT2BRECEPTR.
PE 2: Evidence at transcript level;
KW Behavior; Cell membrane; G-protein coupled receptor; Glycoprotein;
KW Lipoprotein; Membrane; Palmitate; Receptor; Reference proteome; Synapse;
KW Synaptosome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN <1..>96
FT /note="5-hydroxytryptamine receptor 2B"
FT /id="PRO_0000068952"
FT TOPO_DOM <1..8
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:P41595"
FT TRANSMEM 9..30
FT /note="Helical; Name=7"
FT /evidence="ECO:0000250|UniProtKB:P41595"
FT TOPO_DOM 31..>96
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:P41595"
FT MOTIF 24..28
FT /note="NPxxY motif; important for ligand-induced
FT conformation changes and signaling"
FT /evidence="ECO:0000250|UniProtKB:P41595"
FT LIPID 45
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT NON_TER 1
FT NON_TER 96
SQ SEQUENCE 96 AA; 11226 MW; ED35252CD8A6D842 CRC64;
CNQSTLQMLL EIFVWIGYVS SGVNPLVYTL FNKTFRDAFG RYITCNYKAT KSVKTVRKCS
NKIYFRNPMT ENSKFFMKHG MRNGINSTMY QSPVRL
