ID   LOLA_YERPE              Reviewed;         202 AA.
AC   Q8ZGC6; Q0WH38;
DT   11-JUL-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 129.
DE   RecName: Full=Outer-membrane lipoprotein carrier protein {ECO:0000255|HAMAP-Rule:MF_00240};
DE   Flags: Precursor;
GN   Name=lolA {ECO:0000255|HAMAP-Rule:MF_00240};
GN   OrderedLocusNames=YPO1377, y2798, YP_1216;
OS   Yersinia pestis.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=632;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CO-92 / Biovar Orientalis;
RX   PubMed=11586360; DOI=10.1038/35097083;
RA   Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA   Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA   Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA   Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA   Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA   Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA   Stevens K., Whitehead S., Barrell B.G.;
RT   "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL   Nature 413:523-527(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KIM10+ / Biovar Mediaevalis;
RX   PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA   Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA   Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA   Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA   Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT   "Genome sequence of Yersinia pestis KIM.";
RL   J. Bacteriol. 184:4601-4611(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=91001 / Biovar Mediaevalis;
RX   PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA   Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA   Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA   Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA   Wang J., Huang P., Yang R.;
RT   "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT   avirulent to humans.";
RL   DNA Res. 11:179-197(2004).
RN   [4]
RP   X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 21-202.
RG   Center for Structural Genomics of Infectious Diseases (CSGID);
RA   Halavaty A.S., Wawrzak Z., Kudritska M., Savchenko A., Anderson W.F.;
RT   "1.70 Angstrom resolution crystal structure of outer-membrane lipoprotein
RT   carrier protein (lolA) from Yersinia pestis CO92.";
RL   Submitted (MAY-2013) to the PDB data bank.
CC   -!- FUNCTION: Participates in the translocation of lipoproteins from the
CC       inner membrane to the outer membrane. Only forms a complex with a
CC       lipoprotein if the residue after the N-terminal Cys is not an aspartate
CC       (The Asp acts as a targeting signal to indicate that the lipoprotein
CC       should stay in the inner membrane). {ECO:0000255|HAMAP-Rule:MF_00240}.
CC   -!- SUBUNIT: Monomer. {ECO:0000255|HAMAP-Rule:MF_00240}.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000255|HAMAP-Rule:MF_00240}.
CC   -!- SIMILARITY: Belongs to the LolA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00240}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAS61459.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AL590842; CAL20029.1; -; Genomic_DNA.
DR   EMBL; AE009952; AAM86349.1; -; Genomic_DNA.
DR   EMBL; AE017042; AAS61459.1; ALT_INIT; Genomic_DNA.
DR   PIR; AC0168; AC0168.
DR   RefSeq; WP_002211338.1; NZ_WUCM01000096.1.
DR   RefSeq; YP_002346400.1; NC_003143.1.
DR   PDB; 4KI3; X-ray; 1.70 A; A/B/C/D/E/F/G/H/I/J/K/L=21-202.
DR   PDBsum; 4KI3; -.
DR   AlphaFoldDB; Q8ZGC6; -.
DR   SMR; Q8ZGC6; -.
DR   STRING; 214092.YPO1377; -.
DR   PaxDb; Q8ZGC6; -.
DR   DNASU; 1147745; -.
DR   EnsemblBacteria; AAM86349; AAM86349; y2798.
DR   EnsemblBacteria; AAS61459; AAS61459; YP_1216.
DR   GeneID; 66842163; -.
DR   KEGG; ype:YPO1377; -.
DR   KEGG; ypk:y2798; -.
DR   KEGG; ypm:YP_1216; -.
DR   PATRIC; fig|214092.21.peg.1700; -.
DR   eggNOG; COG2834; Bacteria.
DR   HOGENOM; CLU_087560_1_1_6; -.
DR   OMA; YDPFVEQ; -.
DR   Proteomes; UP000000815; Chromosome.
DR   Proteomes; UP000001019; Chromosome.
DR   Proteomes; UP000002490; Chromosome.
DR   GO; GO:0030288; C:outer membrane-bounded periplasmic space; IBA:GO_Central.
DR   GO; GO:0044874; P:lipoprotein localization to outer membrane; IBA:GO_Central.
DR   GO; GO:0042953; P:lipoprotein transport; IEA:InterPro.
DR   CDD; cd16325; LolA; 1.
DR   HAMAP; MF_00240; LolA; 1.
DR   InterPro; IPR029046; LolA/LolB/LppX.
DR   InterPro; IPR004564; OM_lipoprot_carrier_LolA-like.
DR   InterPro; IPR018323; OM_lipoprot_carrier_LolA_Pbac.
DR   PANTHER; PTHR35869; PTHR35869; 1.
DR   Pfam; PF03548; LolA; 1.
DR   SUPFAM; SSF89392; SSF89392; 1.
DR   TIGRFAMs; TIGR00547; lolA; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Chaperone; Periplasm; Protein transport; Reference proteome;
KW   Signal; Transport.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00240"
FT   CHAIN           22..202
FT                   /note="Outer-membrane lipoprotein carrier protein"
FT                   /id="PRO_0000018289"
SQ   SEQUENCE   202 AA;  22242 MW;  C0B8E7A58C88F76A CRC64;
     MKRLLVACCF LSGLISASAL ADASTDLQNR LSKVNSFHAS FSQAVTSSDG AVVQEGEGEL
     WVKRPNLFNW HMTSPDESVL ISDGETLWFY NPFVEQATAT WLKNATGNTP FMLITRNNPD
     DWKQYNVKQK GDDFELTPKS ASGNLKQFAI SVTPSGTIKS FTAVEQDGQR SAYTLKSQQS
     SVVDASKFTF TPPKGVTLDD QR