ID   LOLC_ECO57              Reviewed;         399 AA.
AC   P0ADC5; P75956; Q9R7N7;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Lipoprotein-releasing system transmembrane protein LolC;
GN   Name=lolC; OrderedLocusNames=Z1757, ECs1494;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Part of an ATP-dependent transport system LolCDE responsible
CC       for the release of lipoproteins targeted to the outer membrane from the
CC       inner membrane. Such a release is dependent of the sorting-signal
CC       (absence of an Asp at position 2 of the mature lipoprotein) and of LolA
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ABC-4 integral membrane protein family.
CC       LolC/E subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE005174; AAG55862.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB34917.1; -; Genomic_DNA.
DR   PIR; B85675; B85675.
DR   PIR; F90815; F90815.
DR   RefSeq; NP_309521.1; NC_002695.1.
DR   RefSeq; WP_000284714.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; P0ADC5; -.
DR   SMR; P0ADC5; -.
DR   STRING; 155864.EDL933_1694; -.
DR   EnsemblBacteria; AAG55862; AAG55862; Z1757.
DR   EnsemblBacteria; BAB34917; BAB34917; ECs_1494.
DR   GeneID; 66670618; -.
DR   GeneID; 912675; -.
DR   KEGG; ece:Z1757; -.
DR   KEGG; ecs:ECs_1494; -.
DR   PATRIC; fig|386585.9.peg.1596; -.
DR   eggNOG; COG4591; Bacteria.
DR   HOGENOM; CLU_000604_8_1_6; -.
DR   OMA; GWWQQNG; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0042953; P:lipoprotein transport; IEA:InterPro.
DR   InterPro; IPR003838; ABC3_permease_dom.
DR   InterPro; IPR011925; LolCE_TM.
DR   InterPro; IPR025857; MacB_PCD.
DR   Pfam; PF02687; FtsX; 1.
DR   Pfam; PF12704; MacB_PCD; 1.
DR   TIGRFAMs; TIGR02212; lolCE; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..399
FT                   /note="Lipoprotein-releasing system transmembrane protein
FT                   LolC"
FT                   /id="PRO_0000201811"
FT   TRANSMEM        25..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        270..290
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        310..330
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        358..378
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   399 AA;  43264 MW;  A2BA2D6AF797A09A CRC64;
     MYQPVALFIG LRYMRGRAAD RFGRFVSWLS TIGITLGVMA LVTVLSVMNG FERELQNNIL
     GLMPQAILSS EHGSLNPQQL PETAVKLDGV NRVAPITTGD VVLQSARSVA VGVMLGIDPA
     QKDPLTPYLV NVKQTDLEPG KYNVILGEQL ASQLGVNRGD QIRVMVPSAS QFTPMGRIPS
     QRLFNVIGTF AANSEVDGYE MLVNIEDASR LMRYPAGNIT GWRLWLDEPL KVDSLSQQKL
     PEGSKWQDWR DRKGELFQAV RMEKNMMGLL LSLIVAVAAF NIITSLGLMV MEKQGEVAIL
     QTQGLTPRQI MMVFMVQGAS AGIIGAILGA ALGALLASQL NNLMPIIGVL LDGAALPVAI
     EPLQVIVIAL VAMAIALLST LYPSWRAAAT QPAEALRYE