ID   LOLC_HAEIN              Reviewed;         393 AA.
AC   P44252;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Lipoprotein-releasing system transmembrane protein LolC;
GN   Name=lolC; OrderedLocusNames=HI_1555;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: Part of an ATP-dependent transport system LolCDE responsible
CC       for the release of lipoproteins targeted to the outer membrane from the
CC       inner membrane. Such a release is dependent of the sorting-signal
CC       (absence of an Asp at position 2 of the mature lipoprotein) and of LolA
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ABC-4 integral membrane protein family.
CC       LolC/E subfamily. {ECO:0000305}.
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DR   EMBL; L42023; AAC23204.1; -; Genomic_DNA.
DR   PIR; A64036; A64036.
DR   RefSeq; NP_439704.1; NC_000907.1.
DR   RefSeq; WP_005654778.1; NC_000907.1.
DR   AlphaFoldDB; P44252; -.
DR   SMR; P44252; -.
DR   STRING; 71421.HI_1555; -.
DR   EnsemblBacteria; AAC23204; AAC23204; HI_1555.
DR   KEGG; hin:HI_1555; -.
DR   PATRIC; fig|71421.8.peg.1626; -.
DR   eggNOG; COG4591; Bacteria.
DR   HOGENOM; CLU_000604_8_1_6; -.
DR   OMA; GWWQQNG; -.
DR   PhylomeDB; P44252; -.
DR   BioCyc; HINF71421:G1GJ1-1575-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0098797; C:plasma membrane protein complex; IBA:GO_Central.
DR   GO; GO:0044874; P:lipoprotein localization to outer membrane; IBA:GO_Central.
DR   GO; GO:0042953; P:lipoprotein transport; IEA:InterPro.
DR   InterPro; IPR003838; ABC3_permease_dom.
DR   InterPro; IPR011925; LolCE_TM.
DR   InterPro; IPR025857; MacB_PCD.
DR   Pfam; PF02687; FtsX; 1.
DR   Pfam; PF12704; MacB_PCD; 1.
DR   TIGRFAMs; TIGR02212; lolCE; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..393
FT                   /note="Lipoprotein-releasing system transmembrane protein
FT                   LolC"
FT                   /id="PRO_0000201813"
FT   TRANSMEM        25..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        262..282
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        314..334
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        356..376
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   393 AA;  43579 MW;  7ABEC4E335D57F34 CRC64;
     MNFPISLYIA LRYWRAKSAD RFGRLVTNLA SLGIVLGVMA LIIVLSVMNG LEGYQKQQVL
     SSIPHAIVSE EQPISTEKTL ENLPHFVQKA VPINTTNVIY QTAKGVSAGQ IIGIQSFSDD
     PLVESFDQTK FNEILPRGEF KLVIGDQLAQ KLGVNIGDKI RLMITENSQY TPFGRVPMQR
     LFTVSDIYYG YGEASGYEAF ANITDIGRLM RIQPQQAQGY RLFLNDPFQI TELPQHFPTQ
     KITDWRVQKG EFFQAVRMEK NMMGLLISLI IVVAISNIVT SLSLMVVDKQ GEIAILQTQG
     LTKSQVRSVF IYQGLLVGFV GTLLGAILGV LATLNLTDIV SAVNPQGVFL PTELSFVQMI
     FVIGFSLLLS LLSTLYPAYR AAKVEPAAAL RYE