ID   LOLC_NEIMA              Reviewed;         415 AA.
AC   P57061; A1IS20;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Lipoprotein-releasing system transmembrane protein LolC;
GN   Name=lolC; OrderedLocusNames=NMA1403;
OS   Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 /
OS   Z2491).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=122587;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15465 / Z2491;
RX   PubMed=10761919; DOI=10.1038/35006655;
RA   Parkhill J., Achtman M., James K.D., Bentley S.D., Churcher C.M.,
RA   Klee S.R., Morelli G., Basham D., Brown D., Chillingworth T., Davies R.M.,
RA   Davis P., Devlin K., Feltwell T., Hamlin N., Holroyd S., Jagels K.,
RA   Leather S., Moule S., Mungall K.L., Quail M.A., Rajandream M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Whitehead S., Spratt B.G.,
RA   Barrell B.G.;
RT   "Complete DNA sequence of a serogroup A strain of Neisseria meningitidis
RT   Z2491.";
RL   Nature 404:502-506(2000).
CC   -!- FUNCTION: Part of an ATP-dependent transport system responsible for the
CC       release of lipoproteins targeted to the outer membrane from the inner
CC       membrane. Such a release is dependent of the sorting-signal (absence of
CC       an Asp at position 2 of the mature lipoprotein) and of LolA (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ABC-4 integral membrane protein family.
CC       LolC/E subfamily. {ECO:0000305}.
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DR   EMBL; AL157959; CAM08570.1; -; Genomic_DNA.
DR   PIR; D81909; D81909.
DR   RefSeq; WP_002237004.1; NC_003116.1.
DR   AlphaFoldDB; P57061; -.
DR   SMR; P57061; -.
DR   EnsemblBacteria; CAM08570; CAM08570; NMA1403.
DR   KEGG; nma:NMA1403; -.
DR   HOGENOM; CLU_000604_8_1_4; -.
DR   OMA; GWWQQNG; -.
DR   BioCyc; NMEN122587:NMA_RS07035-MON; -.
DR   Proteomes; UP000000626; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0042953; P:lipoprotein transport; IEA:InterPro.
DR   InterPro; IPR003838; ABC3_permease_dom.
DR   InterPro; IPR011925; LolCE_TM.
DR   InterPro; IPR025857; MacB_PCD.
DR   Pfam; PF02687; FtsX; 1.
DR   Pfam; PF12704; MacB_PCD; 1.
DR   TIGRFAMs; TIGR02212; lolCE; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..415
FT                   /note="Lipoprotein-releasing system transmembrane protein
FT                   LolC"
FT                   /id="PRO_0000201814"
FT   TRANSMEM        24..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        273..293
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        324..344
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        378..398
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   415 AA;  45302 MW;  789FEA1CB1DFD4C2 CRC64;
     MFSLEAWIGL RYLRAKKRNG FMSFITMVSI AGIALGVTAL IVVLSVMNGF QKEIRGQLLN
     VAPHAEIGYI DNTDTDWRNL LRFTENRKGI LAAAPYVSNQ ALLANAGEIR GVQIRGILPS
     EERKVVEYGD KMPAGKFEDL IPGEFDIILG VGLAEALGAE VGNKVTVITP EGNVTPAGVV
     PRLKQFTVVG LVKTGVYEVD NSLAMTHIQD ARVLYRLDKE VAGLRLKLAD PQNAPALTAK
     LIPEAQRDTV WVRDWTFSNR SYFEAVELEK RMMFIILTLI IAVAAFNLVS SLVMAVTEKQ
     ADIAILRTLG LSPGGVMKIF MVQGAFSGFF GTLAGVVCGV LLGWNVGRVV AFFENLLGVH
     LINSQVYFID YLPSDVDMGD VALIACISLG LSFVATLYPS RRASKTQPAE ALRYE