ID   LOLC_NEIMB              Reviewed;         415 AA.
AC   P57062;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 1.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=Lipoprotein-releasing system transmembrane protein LolC;
GN   Name=lolC; OrderedLocusNames=NMB1235;
OS   Neisseria meningitidis serogroup B (strain MC58).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=122586;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MC58;
RX   PubMed=10710307; DOI=10.1126/science.287.5459.1809;
RA   Tettelin H., Saunders N.J., Heidelberg J.F., Jeffries A.C., Nelson K.E.,
RA   Eisen J.A., Ketchum K.A., Hood D.W., Peden J.F., Dodson R.J., Nelson W.C.,
RA   Gwinn M.L., DeBoy R.T., Peterson J.D., Hickey E.K., Haft D.H.,
RA   Salzberg S.L., White O., Fleischmann R.D., Dougherty B.A., Mason T.M.,
RA   Ciecko A., Parksey D.S., Blair E., Cittone H., Clark E.B., Cotton M.D.,
RA   Utterback T.R., Khouri H.M., Qin H., Vamathevan J.J., Gill J., Scarlato V.,
RA   Masignani V., Pizza M., Grandi G., Sun L., Smith H.O., Fraser C.M.,
RA   Moxon E.R., Rappuoli R., Venter J.C.;
RT   "Complete genome sequence of Neisseria meningitidis serogroup B strain
RT   MC58.";
RL   Science 287:1809-1815(2000).
CC   -!- FUNCTION: Part of an ATP-dependent transport system responsible for the
CC       release of lipoproteins targeted to the outer membrane from the inner
CC       membrane. Such a release is dependent of the sorting-signal (absence of
CC       an Asp at position 2 of the mature lipoprotein) and of LolA (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ABC-4 integral membrane protein family.
CC       LolC/E subfamily. {ECO:0000305}.
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DR   EMBL; AE002098; AAF41616.1; -; Genomic_DNA.
DR   PIR; D81107; D81107.
DR   RefSeq; NP_274259.1; NC_003112.2.
DR   RefSeq; WP_002225196.1; NC_003112.2.
DR   AlphaFoldDB; P57062; -.
DR   SMR; P57062; -.
DR   STRING; 122586.NMB1235; -.
DR   PaxDb; P57062; -.
DR   EnsemblBacteria; AAF41616; AAF41616; NMB1235.
DR   KEGG; nme:NMB1235; -.
DR   PATRIC; fig|122586.8.peg.1545; -.
DR   HOGENOM; CLU_000604_8_1_4; -.
DR   OMA; GWWQQNG; -.
DR   Proteomes; UP000000425; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0098797; C:plasma membrane protein complex; IBA:GO_Central.
DR   GO; GO:0044874; P:lipoprotein localization to outer membrane; IBA:GO_Central.
DR   GO; GO:0042953; P:lipoprotein transport; IEA:InterPro.
DR   InterPro; IPR003838; ABC3_permease_dom.
DR   InterPro; IPR011925; LolCE_TM.
DR   InterPro; IPR025857; MacB_PCD.
DR   Pfam; PF02687; FtsX; 1.
DR   Pfam; PF12704; MacB_PCD; 1.
DR   TIGRFAMs; TIGR02212; lolCE; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..415
FT                   /note="Lipoprotein-releasing system transmembrane protein
FT                   LolC"
FT                   /id="PRO_0000201815"
FT   TRANSMEM        24..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        273..293
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        324..344
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        378..398
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   415 AA;  45293 MW;  48D172B2D9605B6E CRC64;
     MFSLEAWIGL RYLRAKKRNG FMSFITMVSI AGIALGVTAL IVVLSVMNGF QKEIRGQLLN
     VAPHAEIGYI DNTDTDWRNL LRFTENRKGI LAAAPYVSNQ ALLANAGEIR GVQMRGILPS
     EERKVVEYGD KMPAGKFEDL IPGEFDIILG VGLAEALGAE VGNKVTVITP EGNVTPAGVV
     PRLKQFTVVG LVKTGVYEVD NSLAMTHIQD ARVLYRLDKE VAGLRLKLAD PQNAPALTAT
     LIPEAQRDAV WVRDWTYSNR SYFEAVELEK RMMFIILTLI IAVAAFNLVS SLVMAVTEKQ
     ADIAILRTLG LSPAGVMKIF MVQGAFSGFF GTLAGVVCGV LLGWNVGRVV AFFENLLGVH
     LINSQVYFID YLPSDVDMGD VALIACISLG LSFVATLYPS RRASKTQPAE ALRYE