LOLD_AQUAE
ID LOLD_AQUAE Reviewed; 224 AA.
AC O66646;
DT 24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Lipoprotein-releasing system ATP-binding protein LolD {ECO:0000255|HAMAP-Rule:MF_01708};
DE EC=7.6.2.- {ECO:0000255|HAMAP-Rule:MF_01708};
GN Name=lolD {ECO:0000255|HAMAP-Rule:MF_01708}; OrderedLocusNames=aq_297;
OS Aquifex aeolicus (strain VF5).
OC Bacteria; Aquificae; Aquificales; Aquificaceae; Aquifex.
OX NCBI_TaxID=224324;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VF5;
RX PubMed=9537320; DOI=10.1038/32831;
RA Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L.,
RA Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R.,
RA Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.;
RT "The complete genome of the hyperthermophilic bacterium Aquifex aeolicus.";
RL Nature 392:353-358(1998).
CC -!- FUNCTION: Part of the ABC transporter complex LolCDE involved in the
CC translocation of mature outer membrane-directed lipoproteins, from the
CC inner membrane to the periplasmic chaperone, LolA. Responsible for the
CC formation of the LolA-lipoprotein complex in an ATP-dependent manner.
CC {ECO:0000255|HAMAP-Rule:MF_01708}.
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (LolD) and
CC two transmembrane proteins (LolC and LolE). {ECO:0000255|HAMAP-
CC Rule:MF_01708}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01708}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01708}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. Lipoprotein
CC translocase (TC 3.A.1.125) family. {ECO:0000255|HAMAP-Rule:MF_01708}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE000657; AAC06596.1; -; Genomic_DNA.
DR PIR; B70327; B70327.
DR RefSeq; NP_213206.1; NC_000918.1.
DR RefSeq; WP_010880144.1; NC_000918.1.
DR PDB; 2PCJ; X-ray; 1.70 A; A/B=1-224.
DR PDB; 2PCL; X-ray; 1.70 A; A=1-224.
DR PDBsum; 2PCJ; -.
DR PDBsum; 2PCL; -.
DR AlphaFoldDB; O66646; -.
DR SMR; O66646; -.
DR STRING; 224324.aq_297; -.
DR EnsemblBacteria; AAC06596; AAC06596; aq_297.
DR KEGG; aae:aq_297; -.
DR eggNOG; COG1136; Bacteria.
DR HOGENOM; CLU_000604_1_22_0; -.
DR InParanoid; O66646; -.
DR OMA; FVYQSHR; -.
DR OrthoDB; 1181903at2; -.
DR EvolutionaryTrace; O66646; -.
DR Proteomes; UP000000798; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR CDD; cd03255; ABC_MJ0796_LolCDE_FtsE; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR017911; MacB_ATP-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
DR PROSITE; PS51244; LOLD; 1.
PE 1: Evidence at protein level;
KW 3D-structure; ATP-binding; Cell inner membrane; Cell membrane; Membrane;
KW Nucleotide-binding; Reference proteome; Translocase; Transport.
FT CHAIN 1..224
FT /note="Lipoprotein-releasing system ATP-binding protein
FT LolD"
FT /id="PRO_0000092417"
FT DOMAIN 5..224
FT /note="ABC transporter"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01708"
FT BINDING 37..44
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01708"
FT STRAND 3..14
FT /evidence="ECO:0007829|PDB:2PCJ"
FT STRAND 17..28
FT /evidence="ECO:0007829|PDB:2PCJ"
FT STRAND 32..37
FT /evidence="ECO:0007829|PDB:2PCJ"
FT HELIX 43..50
FT /evidence="ECO:0007829|PDB:2PCJ"
FT STRAND 57..63
FT /evidence="ECO:0007829|PDB:2PCJ"
FT HELIX 73..83
FT /evidence="ECO:0007829|PDB:2PCJ"
FT STRAND 84..87
FT /evidence="ECO:0007829|PDB:2PCJ"
FT HELIX 99..109
FT /evidence="ECO:0007829|PDB:2PCJ"
FT HELIX 114..127
FT /evidence="ECO:0007829|PDB:2PCJ"
FT HELIX 138..140
FT /evidence="ECO:0007829|PDB:2PCJ"
FT HELIX 143..154
FT /evidence="ECO:0007829|PDB:2PCJ"
FT TURN 155..157
FT /evidence="ECO:0007829|PDB:2PCJ"
FT STRAND 160..166
FT /evidence="ECO:0007829|PDB:2PCJ"
FT TURN 167..170
FT /evidence="ECO:0007829|PDB:2PCJ"
FT HELIX 173..188
FT /evidence="ECO:0007829|PDB:2PCJ"
FT STRAND 192..196
FT /evidence="ECO:0007829|PDB:2PCJ"
FT HELIX 200..203
FT /evidence="ECO:0007829|PDB:2PCJ"
FT STRAND 206..213
FT /evidence="ECO:0007829|PDB:2PCJ"
FT STRAND 216..222
FT /evidence="ECO:0007829|PDB:2PCJ"
SQ SEQUENCE 224 AA; 24887 MW; 0804B347486A963C CRC64;
MAEILRAENI KKVIRGYEIL KGISLSVKKG EFVSIIGASG SGKSTLLYIL GLLDAPTEGK
VFLEGKEVDY TNEKELSLLR NRKLGFVFQF HYLIPELTAL ENVIVPMLKM GKPKKEAKER
GEYLLSELGL GDKLSRKPYE LSGGEQQRVA IARALANEPI LLFADEPTGN LDSANTKRVM
DIFLKINEGG TSIVMVTHER ELAELTHRTL EMKDGKVVGE ITRV
