5HT2B_PIG
ID 5HT2B_PIG Reviewed; 60 AA.
AC Q29005;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=5-hydroxytryptamine receptor 2B;
DE Short=5-HT-2B;
DE Short=5-HT2B;
DE AltName: Full=Serotonin receptor 2B;
DE Flags: Fragment;
GN Name=HTR2B;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Pulmonary artery;
RX PubMed=7656980; DOI=10.1016/0014-5793(95)00828-w;
RA Ullmer C., Schmuck K., Kalkman H.O., Luebbert H.;
RT "Expression of serotonin receptor mRNAs in blood vessels.";
RL FEBS Lett. 370:215-221(1995).
CC -!- FUNCTION: G-protein coupled receptor for 5-hydroxytryptamine
CC (serotonin). Also functions as a receptor for various ergot alkaloid
CC derivatives and psychoactive substances. Ligand binding causes a
CC conformation change that triggers signaling via guanine nucleotide-
CC binding proteins (G proteins) and modulates the activity of down-stream
CC effectors. Beta-arrestin family members inhibit signaling via G
CC proteins and mediate activation of alternative signaling pathways.
CC Signaling activates a phosphatidylinositol-calcium second messenger
CC system that modulates the activity of phosphatidylinositol 3-kinase and
CC down-stream signaling cascades and promotes the release of Ca(2+) ions
CC from intracellular stores. Plays a role in the regulation of dopamine
CC and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the
CC regulation of extracellular dopamine and 5-hydroxytryptamine levels,
CC and thereby affects neural activity. May play a role in the perception
CC of pain. Plays a role in the regulation of behavior, including
CC impulsive behavior. Required for normal proliferation of embryonic
CC cardiac myocytes and normal heart development. Protects cardiomyocytes
CC against apoptosis. Plays a role in the adaptation of pulmonary arteries
CC to chronic hypoxia. Plays a role in vasoconstriction. Required for
CC normal osteoblast function and proliferation, and for maintaining
CC normal bone density. Required for normal proliferation of the
CC interstitial cells of Cajal in the intestine (By similarity).
CC {ECO:0000250|UniProtKB:P41595, ECO:0000250|UniProtKB:Q02152}.
CC -!- SUBUNIT: Interacts (via C-terminus) with MPDZ.
CC {ECO:0000250|UniProtKB:P41595}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P41595};
CC Multi-pass membrane protein {ECO:0000250|UniProtKB:P41595}. Synapse,
CC synaptosome {ECO:0000250|UniProtKB:Q02152}.
CC -!- TISSUE SPECIFICITY: Detected in aorta, renal artery, jugular vein, vena
CC cava and femoral vein. {ECO:0000269|PubMed:7656980}.
CC -!- DOMAIN: Ligands are bound in a hydrophobic pocket formed by the
CC transmembrane helices. {ECO:0000250|UniProtKB:P41595}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; Z48174; CAA88197.1; -; mRNA.
DR PIR; S66491; S66491.
DR AlphaFoldDB; Q29005; -.
DR SMR; Q29005; -.
DR STRING; 9823.ENSSSCP00000017240; -.
DR PaxDb; Q29005; -.
DR eggNOG; KOG3656; Eukaryota.
DR HOGENOM; CLU_009579_11_3_1; -.
DR InParanoid; Q29005; -.
DR Proteomes; UP000008227; Unplaced.
DR Proteomes; UP000314985; Unplaced.
DR Genevisible; Q29005; SS.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
DR GO; GO:0004993; F:G protein-coupled serotonin receptor activity; IBA:GO_Central.
DR GO; GO:0030594; F:neurotransmitter receptor activity; IBA:GO_Central.
DR GO; GO:0007610; P:behavior; IEA:UniProtKB-KW.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0007187; P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; IBA:GO_Central.
DR GO; GO:0007507; P:heart development; IEA:InterPro.
DR GO; GO:0007200; P:phospholipase C-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0050795; P:regulation of behavior; IEA:InterPro.
DR GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IBA:GO_Central.
DR GO; GO:0006939; P:smooth muscle contraction; IEA:InterPro.
DR GO; GO:0042310; P:vasoconstriction; IEA:InterPro.
DR InterPro; IPR000482; 5HT2B_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR24247:SF31; PTHR24247:SF31; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Behavior; Cell membrane; G-protein coupled receptor; Lipoprotein; Membrane;
KW Palmitate; Receptor; Reference proteome; Synapse; Synaptosome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN <1..>60
FT /note="5-hydroxytryptamine receptor 2B"
FT /id="PRO_0000068955"
FT TOPO_DOM <1..4
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:P41595"
FT TRANSMEM 5..26
FT /note="Helical; Name=3"
FT /evidence="ECO:0000250|UniProtKB:P41595"
FT TOPO_DOM 27..46
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:P41595"
FT TRANSMEM 47..60
FT /note="Helical; Name=4"
FT /evidence="ECO:0000250|UniProtKB:P41595"
FT MOTIF 27..29
FT /note="DRY motif; important for ligand-induced conformation
FT changes"
FT /evidence="ECO:0000250|UniProtKB:P41595"
FT BINDING 10
FT /ligand="ergotamine"
FT /ligand_id="ChEBI:CHEBI:190463"
FT /ligand_note="agonist"
FT /evidence="ECO:0000250|UniProtKB:P41595"
FT BINDING 15
FT /ligand="ergotamine"
FT /ligand_id="ChEBI:CHEBI:190463"
FT /ligand_note="agonist"
FT /evidence="ECO:0000250|UniProtKB:P41595"
FT NON_TER 1
FT NON_TER 60
SQ SEQUENCE 60 AA; 6725 MW; 920DCF0D76A8404B CRC64;
VLCPAWLFLD VLFSTASIMH LCAISVDRYI AIKKPIQANQ YNSRATAFIK ITVVWLISIG
