ID   LOLE_HAEIN              Reviewed;         416 AA.
AC   P44250;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Lipoprotein-releasing system transmembrane protein LolE;
GN   Name=lolE; OrderedLocusNames=HI_1548;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: Part of an ATP-dependent transport system LolCDE responsible
CC       for the release of lipoproteins targeted to the outer membrane from the
CC       inner membrane. Such a release is dependent of the sorting-signal
CC       (absence of an Asp at position 2 of the mature lipoprotein) and of LolA
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ABC-4 integral membrane protein family.
CC       LolC/E subfamily. {ECO:0000305}.
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DR   EMBL; L42023; AAC23198.1; -; Genomic_DNA.
DR   PIR; H64035; H64035.
DR   RefSeq; NP_439697.1; NC_000907.1.
DR   RefSeq; WP_010869243.1; NC_000907.1.
DR   AlphaFoldDB; P44250; -.
DR   SMR; P44250; -.
DR   STRING; 71421.HI_1548; -.
DR   EnsemblBacteria; AAC23198; AAC23198; HI_1548.
DR   KEGG; hin:HI_1548; -.
DR   PATRIC; fig|71421.8.peg.1619; -.
DR   eggNOG; COG4591; Bacteria.
DR   HOGENOM; CLU_000604_8_1_6; -.
DR   OMA; ERTQMIG; -.
DR   PhylomeDB; P44250; -.
DR   BioCyc; HINF71421:G1GJ1-1568-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0098797; C:plasma membrane protein complex; IBA:GO_Central.
DR   GO; GO:0044874; P:lipoprotein localization to outer membrane; IBA:GO_Central.
DR   GO; GO:0042953; P:lipoprotein transport; IEA:InterPro.
DR   InterPro; IPR003838; ABC3_permease_dom.
DR   InterPro; IPR011925; LolCE_TM.
DR   InterPro; IPR011926; LolE_gammaproteobact.
DR   InterPro; IPR025857; MacB_PCD.
DR   Pfam; PF02687; FtsX; 1.
DR   Pfam; PF12704; MacB_PCD; 1.
DR   TIGRFAMs; TIGR02212; lolCE; 1.
DR   TIGRFAMs; TIGR02213; lolE_release; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..416
FT                   /note="Lipoprotein-releasing system transmembrane protein
FT                   LolE"
FT                   /id="PRO_0000201819"
FT   TRANSMEM        21..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        276..296
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        334..354
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        379..399
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   416 AA;  46229 MW;  F9578BB3BC9DFC5B CRC64;
     MNTPFFISWR YQRGKQKNPL VALIAKFSAI GIALGVAVLI VGLSAMNGFE RELNQRILAV
     VPHAEILSAP NATEPTIHHW QNLEKRLQQN PQIKGISPFV SFTALVENGS KLKVVQVKGV
     EKQAEDKVSS IGNFVQEQGW NKFEKEGGLV LGSGIAKELD VKVGDWITLL ISQQNGDEQF
     AQPTREPVQV TSILRLDGQL DYSYALLPLA QAQTFLTYQP DQITGVELKL DDPFSARNLD
     LSMLNDYPQM LYMQNWISKF GYMYRDIQLI RTVMYIAMVL VIGVACFNIV STLIMAVKDK
     QGDIAIMRTL GANNAFIKRI FIWYGLQAGM KGCLIGIVLG IILALNLTTF IQGIEWVIGK
     KLLSGDVYFV DFLPSELHWL DVLMVLVAAL ALSLMASLYP ASRAAKLQPA QVLSSH