ID   LOLU1_EPIUN             Reviewed;         495 AA.
AC   Q5MNI2;
DT   23-MAY-2018, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 21.
DE   RecName: Full=Loline biosynthesis cluster 1 transcription factor lolU1 {ECO:0000303|PubMed:15654104};
GN   Name=lolU1 {ECO:0000303|PubMed:15654104};
GN   Synonyms=lolU {ECO:0000303|PubMed:15654104};
OS   Epichloe uncinata (Endophyte fungus) (Neotyphodium uncinatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Clavicipitaceae; Epichloe.
OX   NCBI_TaxID=5050;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], INDUCTION, AND FUNCTION.
RC   STRAIN=CBS 102646;
RX   PubMed=15654104; DOI=10.1534/genetics.104.035972;
RA   Spiering M.J., Moon C.D., Wilkinson H.H., Schardl C.L.;
RT   "Gene clusters for insecticidal loline alkaloids in the grass-endophytic
RT   fungus Neotyphodium uncinatum.";
RL   Genetics 169:1403-1414(2005).
CC   -!- FUNCTION: Transcriptional regulator that may regulate the expression of
CC       the loline biosynthesis cluster 1, one of the 2 clusters involved in
CC       the biosynthesis of loline alkaloids, potent insecticidal agents
CC       composed of a pyrrolizidine ring system and an uncommon ether bridge
CC       linking carbons 2 and 7 (PubMed:15654104).
CC       {ECO:0000305|PubMed:15654104}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- INDUCTION: Expression is induced in loline alkaloid-producing cultures
CC       as well as in planta (PubMed:15654104). {ECO:0000269|PubMed:15654104}.
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DR   EMBL; AY723749; AAV68707.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q5MNI2; -.
DR   SMR; Q5MNI2; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0009820; P:alkaloid metabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.559.10; -; 1.
DR   InterPro; IPR023213; CAT-like_dom_sf.
PE   2: Evidence at transcript level;
KW   Alkaloid metabolism; Nucleus; Transcription; Transcription regulation.
FT   CHAIN           1..495
FT                   /note="Loline biosynthesis cluster 1 transcription factor
FT                   lolU1"
FT                   /id="PRO_0000444367"
SQ   SEQUENCE   495 AA;  55143 MW;  9C7D9CFABF084697 CRC64;
     MASPGNHAIV APGWTRSEDG SLTRPLDLVE NWLLARIQRA NTPPGREAEG LTYKLKLRLP
     QDIDDPIPYL RRAWLVFRYV QPLIGAIYPP YSERDETGRY LVTVPLMDPE EWLRLSFHVN
     QGTQAVFRDV DDAGKIFQPR PTAMAYWFPP SSTLIIRSTH LRFDAVGIYK ATNTFMLGLE
     SVFRLGLDAN LDCYTTDVKQ PSLPPGIDYI LGFPPQETPV PHRVERAVDE LMRHWHHGLY
     SLSLPVREGS EDAAPANTQH LVTLFDEPTL EAIVAGCKKL GVSVSAAVHA SIVRVWASFP
     QQQHTGARNM LIPLVANLRP LLDPKWVVPD YALGLCIFVV PFCLTGGFED LTQRLGAVYS
     RDLSALPSDP AGDPVSFLEL LPLYESREAA FLGSLPVAGC PPFRVPNLSS LGVLERYLAR
     AYGKKGAQAP VCEIEDVALV NATTDPTIEF QLFTFRGTMR LYLYYNDAYY TEDFLAPVME
     MVRDSLLQEL GLGGS