ID   LOLU2_EPIUN             Reviewed;         506 AA.
AC   Q5MNH4;
DT   23-MAY-2018, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 21.
DE   RecName: Full=Loline biosynthesis cluster 2 transcription factor lolU2 {ECO:0000303|PubMed:15654104};
GN   Name=lolU2 {ECO:0000303|PubMed:15654104};
GN   Synonyms=lolU {ECO:0000303|PubMed:15654104};
OS   Epichloe uncinata (Endophyte fungus) (Neotyphodium uncinatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Clavicipitaceae; Epichloe.
OX   NCBI_TaxID=5050;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], INDUCTION, AND FUNCTION.
RC   STRAIN=CBS 102646;
RX   PubMed=15654104; DOI=10.1534/genetics.104.035972;
RA   Spiering M.J., Moon C.D., Wilkinson H.H., Schardl C.L.;
RT   "Gene clusters for insecticidal loline alkaloids in the grass-endophytic
RT   fungus Neotyphodium uncinatum.";
RL   Genetics 169:1403-1414(2005).
CC   -!- FUNCTION: Transcriptional regulator that may regulate the expression of
CC       the loline biosynthesis cluster 1, one of the 2 clusters involved in
CC       the biosynthesis of loline alkaloids, potent insecticidal agents
CC       composed of a pyrrolizidine ring system and an uncommon ether bridge
CC       linking carbons 2 and 7 (PubMed:15654104).
CC       {ECO:0000305|PubMed:15654104}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- INDUCTION: Expression is induced in loline alkaloid-producing cultures
CC       as well as in planta (PubMed:15654104). {ECO:0000269|PubMed:15654104}.
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DR   EMBL; AY723750; AAV68699.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q5MNH4; -.
DR   SMR; Q5MNH4; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0009820; P:alkaloid metabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.559.10; -; 1.
DR   InterPro; IPR023213; CAT-like_dom_sf.
PE   2: Evidence at transcript level;
KW   Alkaloid metabolism; Nucleus; Transcription; Transcription regulation.
FT   CHAIN           1..506
FT                   /note="Loline biosynthesis cluster 2 transcription factor
FT                   lolU2"
FT                   /id="PRO_0000444368"
SQ   SEQUENCE   506 AA;  56174 MW;  523329173773C21D CRC64;
     MVSAGNHAIV ALGWTTSEDG TLTRPLDLVE NWLLARIQRA NTPPGREAEG LTYKLKLRLP
     QDIDDPIPYL RRAWLVFRYV QPLIGAIYPP YSERDETGRY LVTVPPMDPE EWLRLSFHVN
     QGSQAVFRDV DDAGMIFRPR PTAMAYWFPP SSTLVIRSTH LRFDAVGLYK ATNTFMLGLE
     SVFRLGLDAN LDCYTTDVKQ PSLPPGIDYI LGFPPQETPV SHRVGCAVDE LMRHWHHGLY
     SLSLPVREGS EDAAPANTQH MVTLFDEPTL EAIVAGCKEL GVSVSAAVHA SIVRVWASFP
     QQQHTGARNM LIPLVANLRP LLDPKWVVPD YALSLCIFVV PFCLTGGFED LTQRLGAVYS
     RDLSALPSDS AGDPVSFLEL LPLYDSQEAA FLGSLPVAGC PPFRVPNLSS LGVLERYLAR
     AYGQKGAQAP VCEIEDVALV NATTDPTIEF QLFTFRGTMR LYLYYNDAYY TEDFLASVME
     MVRESLLQEL GLDGSESSEG LDPKEA