LON3_CAEEL
ID LON3_CAEEL Reviewed; 324 AA.
AC Q23628;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Cuticle collagen lon-3;
DE Flags: Precursor;
GN Name=lon-3; ORFNames=ZK836.1;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=12019225; DOI=10.1093/genetics/161.1.83;
RA Nystroem J., Shen Z.-Z., Aili M., Flemming A.J., Leroi A., Tuck S.P.;
RT "Increased or decreased levels of Caenorhabditis elegans lon-3, a gene
RT encoding a collagen, cause reciprocal changes in body length.";
RL Genetics 161:83-97(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=12524338; DOI=10.1093/genetics/162.4.1631;
RA Suzuki Y., Morris G.A., Han M., Wood W.B.;
RT "A cuticle collagen encoded by the lon-3 gene may be a target of TGF-beta
RT signaling in determining Caenorhabditis elegans body shape.";
RL Genetics 162:1631-1639(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Nematode cuticles are composed largely of collagen-like
CC proteins. The cuticle functions both as an exoskeleton and as a barrier
CC to protect the worm from its environment. Dose-dependent regulator of
CC body length and shape.
CC -!- SUBUNIT: Collagen polypeptide chains are complexed within the cuticle
CC by disulfide bonds and other types of covalent cross-links.
CC -!- SIMILARITY: Belongs to the cuticular collagen family. {ECO:0000305}.
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DR EMBL; AF262406; AAL08218.1; -; mRNA.
DR EMBL; AF465981; AAL76993.1; -; mRNA.
DR EMBL; Z78201; CAB01588.1; -; Genomic_DNA.
DR PIR; T28032; T28032.
DR RefSeq; NP_506061.1; NM_073660.5.
DR AlphaFoldDB; Q23628; -.
DR SMR; Q23628; -.
DR BioGRID; 44696; 1.
DR DIP; DIP-25736N; -.
DR IntAct; Q23628; 2.
DR STRING; 6239.ZK836.1; -.
DR EPD; Q23628; -.
DR PaxDb; Q23628; -.
DR PeptideAtlas; Q23628; -.
DR PRIDE; Q23628; -.
DR EnsemblMetazoa; ZK836.1.1; ZK836.1.1; WBGene00003057.
DR GeneID; 179673; -.
DR KEGG; cel:CELE_ZK836.1; -.
DR UCSC; ZK836.1; c. elegans.
DR CTD; 179673; -.
DR WormBase; ZK836.1; CE15415; WBGene00003057; lon-3.
DR eggNOG; KOG3544; Eukaryota.
DR GeneTree; ENSGT00940000174005; -.
DR HOGENOM; CLU_001074_4_4_1; -.
DR InParanoid; Q23628; -.
DR OMA; NDIWGDM; -.
DR PhylomeDB; Q23628; -.
DR PRO; PR:Q23628; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00003057; Expressed in larva and 4 other tissues.
DR GO; GO:0060107; C:annuli extracellular matrix; IDA:WormBase.
DR GO; GO:0060102; C:collagen and cuticulin-based cuticle extracellular matrix; IDA:WormBase.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0042329; F:structural constituent of collagen and cuticulin-based cuticle; ISS:WormBase.
DR GO; GO:0010171; P:body morphogenesis; IGI:WormBase.
DR GO; GO:0040015; P:negative regulation of multicellular organism growth; IMP:WormBase.
DR InterPro; IPR002486; Col_cuticle_N.
DR InterPro; IPR008160; Collagen.
DR Pfam; PF01484; Col_cuticle_N; 1.
DR Pfam; PF01391; Collagen; 1.
DR SMART; SM01088; Col_cuticle_N; 1.
PE 2: Evidence at transcript level;
KW Collagen; Cuticle; Disulfide bond; Reference proteome; Repeat; Signal.
FT SIGNAL 1..30
FT /evidence="ECO:0000255"
FT CHAIN 31..324
FT /note="Cuticle collagen lon-3"
FT /id="PRO_0000006431"
FT REGION 119..324
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 129..152
FT /note="Triple-helical region"
FT REGION 170..229
FT /note="Triple-helical region"
FT REGION 235..294
FT /note="Triple-helical region"
FT COMPBIAS 155..173
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 300..314
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 324 AA; 32941 MW; F765A9A811DF146F CRC64;
MSVTTATSGA LIFSGASLLV SLFAAASIYS QVSSIWTELD NEIDSFKLLT NDIWGDMINL
GAGSASNRIR RQAYGGYGAT GTNAPEPQFP QGDKGPLPVP GLPFGPNVSG GSDRCQCTVE
NTCPTGPDGE EGEQGPDGQD GVDGVPGFDG QDCPDVEQQP SQGCFTCPQG LPGPQGSQGA
PGIRGMRGAR GQPGYPGRDG QPGMPGEMGP TGAPGDDGAP GASGMKGDDA EKPVGRQGQR
GQPGEQGPDG EEGPAGKDAF EGPPGVEGEV GVPGYQGSAG PDGEEGPRGP SGLPGKDAEY
CKCPTRDDGG NSHRAWRRKH KRVY
