LON8_CAEEL
ID LON8_CAEEL Reviewed; 162 AA.
AC G5EGH7;
DT 08-JUN-2016, integrated into UniProtKB/Swiss-Prot.
DT 14-DEC-2011, sequence version 1.
DT 03-AUG-2022, entry version 55.
DE RecName: Full=Protein lon-8 {ECO:0000312|WormBase:Y59A8B.20};
DE Flags: Precursor;
GN Name=lon-8 {ECO:0000312|WormBase:Y59A8B.20};
GN ORFNames=Y59A8B.20 {ECO:0000312|WormBase:Y59A8B.20};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|EMBL:ABP48104.1}
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL
RP STAGE, AND DISRUPTION PHENOTYPE.
RX PubMed=17374156; DOI=10.1186/1471-213x-7-20;
RA Soete G., Betist M.C., Korswagen H.C.;
RT "Regulation of Caenorhabditis elegans body size and male tail development
RT by the novel gene lon-8.";
RL BMC Dev. Biol. 7:20-20(2007).
RN [2] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Secreted protein that is involved in larval elongation, early
CC adult growth and male tail development. {ECO:0000269|PubMed:17374156}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:17374156}.
CC -!- DEVELOPMENTAL STAGE: Expressed in the hypodermal regions hyp4 and hyp7
CC from the comma stage of embryogenesis and subsequently throughout
CC development. {ECO:0000269|PubMed:17374156}.
CC -!- DISRUPTION PHENOTYPE: Mutants display an increased body growth rate
CC during larval development and male tail morphological defects
CC characterized by thickening of the male rays, with rays 5 and 6 the
CC most severely affected in most cases. RNAi-mediated knockdown results
CC in increased body length. {ECO:0000269|PubMed:17374156}.
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DR EMBL; EF495354; ABP48104.1; -; mRNA.
DR EMBL; BX284605; CAB60948.3; -; Genomic_DNA.
DR RefSeq; NP_507520.3; NM_075119.4.
DR AlphaFoldDB; G5EGH7; -.
DR STRING; 6239.Y59A8B.20; -.
DR EPD; G5EGH7; -.
DR PaxDb; G5EGH7; -.
DR PeptideAtlas; G5EGH7; -.
DR EnsemblMetazoa; Y59A8B.20.1; Y59A8B.20.1; WBGene00013352.
DR GeneID; 190397; -.
DR KEGG; cel:CELE_Y59A8B.20; -.
DR CTD; 190397; -.
DR WormBase; Y59A8B.20; CE41522; WBGene00013352; lon-8.
DR eggNOG; ENOG502RXJI; Eukaryota.
DR HOGENOM; CLU_1654083_0_0_1; -.
DR InParanoid; G5EGH7; -.
DR OMA; RTKQECE; -.
DR OrthoDB; 1357842at2759; -.
DR PRO; PR:G5EGH7; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00013352; Expressed in larva and 3 other tissues.
DR GO; GO:0005615; C:extracellular space; ISS:WormBase.
DR GO; GO:0040015; P:negative regulation of multicellular organism growth; IMP:WormBase.
DR GO; GO:0045138; P:nematode male tail tip morphogenesis; IMP:WormBase.
PE 2: Evidence at transcript level;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..162
FT /note="Protein lon-8"
FT /evidence="ECO:0000305"
FT /id="PRO_5006953821"
SQ SEQUENCE 162 AA; 18463 MW; EDD574CCAA50A529 CRC64;
MRNSRFCAIL AVISAISVSY VLAQRSQQSV IADLGKLIVD NCPPMLCTGL DCAVVTERNG
CQLCACPIGS PSRGCDPMPF ILWHDLIVNG CPNVTLNSRD PAQKVHRWFR RVNRFTNTDQ
CEPYIFPYCP ELDFNLWRSP RTKQECELYC YSIDEQRKRG II
