LONF1_HUMAN
ID LONF1_HUMAN Reviewed; 773 AA.
AC Q17RB8; B4DM29; B4DU84; Q8TEA0; Q9BSV1;
DT 20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-SEP-2009, sequence version 2.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=LON peptidase N-terminal domain and RING finger protein 1;
DE AltName: Full=RING finger protein 191;
GN Name=LONRF1; Synonyms=RNF191;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA Platzer M., Shimizu N., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 268-773 (ISOFORM 1), AND
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 387-773 (ISOFORM 2).
RC TISSUE=Hepatoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 337-773 (ISOFORM 1).
RC TISSUE=Brain, and Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q17RB8; Q6UY14-3: ADAMTSL4; NbExp=6; IntAct=EBI-2341787, EBI-10173507;
CC Q17RB8; P13196: ALAS1; NbExp=6; IntAct=EBI-2341787, EBI-3905054;
CC Q17RB8; P63010-2: AP2B1; NbExp=3; IntAct=EBI-2341787, EBI-11529439;
CC Q17RB8; Q7Z3C6: ATG9A; NbExp=3; IntAct=EBI-2341787, EBI-727146;
CC Q17RB8; Q5T686: AVPI1; NbExp=3; IntAct=EBI-2341787, EBI-8640233;
CC Q17RB8; Q6PI77: BHLHB9; NbExp=3; IntAct=EBI-2341787, EBI-11519926;
CC Q17RB8; Q13895: BYSL; NbExp=8; IntAct=EBI-2341787, EBI-358049;
CC Q17RB8; Q53FE4: C4orf17; NbExp=3; IntAct=EBI-2341787, EBI-715110;
CC Q17RB8; Q13137: CALCOCO2; NbExp=3; IntAct=EBI-2341787, EBI-739580;
CC Q17RB8; Q8N7E2: CBLL2; NbExp=3; IntAct=EBI-2341787, EBI-12196065;
CC Q17RB8; P55273: CDKN2D; NbExp=3; IntAct=EBI-2341787, EBI-745859;
CC Q17RB8; P27918: CFP; NbExp=3; IntAct=EBI-2341787, EBI-9038570;
CC Q17RB8; O43186: CRX; NbExp=5; IntAct=EBI-2341787, EBI-748171;
CC Q17RB8; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-2341787, EBI-3867333;
CC Q17RB8; Q92997: DVL3; NbExp=3; IntAct=EBI-2341787, EBI-739789;
CC Q17RB8; Q5JST6: EFHC2; NbExp=6; IntAct=EBI-2341787, EBI-2349927;
CC Q17RB8; Q96Q35-2: FLACC1; NbExp=3; IntAct=EBI-2341787, EBI-11533409;
CC Q17RB8; Q8TAK5: GABPB2; NbExp=3; IntAct=EBI-2341787, EBI-8468945;
CC Q17RB8; Q9BQQ3: GORASP1; NbExp=6; IntAct=EBI-2341787, EBI-2561458;
CC Q17RB8; Q9H8Y8: GORASP2; NbExp=10; IntAct=EBI-2341787, EBI-739467;
CC Q17RB8; Q14774: HLX; NbExp=3; IntAct=EBI-2341787, EBI-6678255;
CC Q17RB8; P49639: HOXA1; NbExp=3; IntAct=EBI-2341787, EBI-740785;
CC Q17RB8; Q8IYA8: IHO1; NbExp=6; IntAct=EBI-2341787, EBI-8638439;
CC Q17RB8; Q9UKS7: IKZF2; NbExp=3; IntAct=EBI-2341787, EBI-3893057;
CC Q17RB8; Q9UKT9: IKZF3; NbExp=3; IntAct=EBI-2341787, EBI-747204;
CC Q17RB8; Q8IXL9: IQCF2; NbExp=3; IntAct=EBI-2341787, EBI-10238842;
CC Q17RB8; Q92993: KAT5; NbExp=3; IntAct=EBI-2341787, EBI-399080;
CC Q17RB8; Q9H079: KATNBL1; NbExp=3; IntAct=EBI-2341787, EBI-715394;
CC Q17RB8; Q4G0X4: KCTD21; NbExp=3; IntAct=EBI-2341787, EBI-11976683;
CC Q17RB8; Q7L273: KCTD9; NbExp=6; IntAct=EBI-2341787, EBI-4397613;
CC Q17RB8; Q15323: KRT31; NbExp=6; IntAct=EBI-2341787, EBI-948001;
CC Q17RB8; Q92764: KRT35; NbExp=3; IntAct=EBI-2341787, EBI-1058674;
CC Q17RB8; O95678: KRT75; NbExp=3; IntAct=EBI-2341787, EBI-2949715;
CC Q17RB8; Q8IUG1: KRTAP1-3; NbExp=3; IntAct=EBI-2341787, EBI-11749135;
CC Q17RB8; Q3SY46: KRTAP13-3; NbExp=3; IntAct=EBI-2341787, EBI-10241252;
CC Q17RB8; Q3LI70: KRTAP19-6; NbExp=3; IntAct=EBI-2341787, EBI-12805508;
CC Q17RB8; Q3SYF9: KRTAP19-7; NbExp=3; IntAct=EBI-2341787, EBI-10241353;
CC Q17RB8; Q9BYR6: KRTAP3-3; NbExp=3; IntAct=EBI-2341787, EBI-3957694;
CC Q17RB8; Q3LI64: KRTAP6-1; NbExp=3; IntAct=EBI-2341787, EBI-12111050;
CC Q17RB8; Q3B8N2: LGALS9B; NbExp=3; IntAct=EBI-2341787, EBI-10240775;
CC Q17RB8; P50458: LHX2; NbExp=3; IntAct=EBI-2341787, EBI-12179869;
CC Q17RB8; Q969G2: LHX4; NbExp=3; IntAct=EBI-2341787, EBI-2865388;
CC Q17RB8; Q8TBB1: LNX1; NbExp=3; IntAct=EBI-2341787, EBI-739832;
CC Q17RB8; Q9Y5V3: MAGED1; NbExp=3; IntAct=EBI-2341787, EBI-716006;
CC Q17RB8; Q9UJV3-2: MID2; NbExp=3; IntAct=EBI-2341787, EBI-10172526;
CC Q17RB8; Q96DV4: MRPL38; NbExp=3; IntAct=EBI-2341787, EBI-720441;
CC Q17RB8; Q13615: MTMR3; NbExp=3; IntAct=EBI-2341787, EBI-371938;
CC Q17RB8; Q8TDC0: MYOZ3; NbExp=3; IntAct=EBI-2341787, EBI-5662487;
CC Q17RB8; P22736: NR4A1; NbExp=3; IntAct=EBI-2341787, EBI-721550;
CC Q17RB8; Q96HA8: NTAQ1; NbExp=4; IntAct=EBI-2341787, EBI-741158;
CC Q17RB8; A6NGQ2: OOEP; NbExp=3; IntAct=EBI-2341787, EBI-18583589;
CC Q17RB8; Q9HBE1-4: PATZ1; NbExp=3; IntAct=EBI-2341787, EBI-11022007;
CC Q17RB8; Q02548: PAX5; NbExp=3; IntAct=EBI-2341787, EBI-296331;
CC Q17RB8; P26367: PAX6; NbExp=3; IntAct=EBI-2341787, EBI-747278;
CC Q17RB8; Q06710: PAX8; NbExp=3; IntAct=EBI-2341787, EBI-2683132;
CC Q17RB8; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-2341787, EBI-79165;
CC Q17RB8; Q8WVK1: PLSCR1; NbExp=3; IntAct=EBI-2341787, EBI-10238872;
CC Q17RB8; P78424: POU6F2; NbExp=3; IntAct=EBI-2341787, EBI-12029004;
CC Q17RB8; Q9UQK1: PPP1R3C; NbExp=3; IntAct=EBI-2341787, EBI-2506727;
CC Q17RB8; Q9NQX0: PRDM6; NbExp=3; IntAct=EBI-2341787, EBI-11320284;
CC Q17RB8; P0CG20: PRR35; NbExp=3; IntAct=EBI-2341787, EBI-11986293;
CC Q17RB8; P25786: PSMA1; NbExp=3; IntAct=EBI-2341787, EBI-359352;
CC Q17RB8; Q93062: RBPMS; NbExp=3; IntAct=EBI-2341787, EBI-740322;
CC Q17RB8; Q9UFD9: RIMBP3; NbExp=3; IntAct=EBI-2341787, EBI-10182375;
CC Q17RB8; Q96P16-3: RPRD1A; NbExp=3; IntAct=EBI-2341787, EBI-12840198;
CC Q17RB8; P31947: SFN; NbExp=3; IntAct=EBI-2341787, EBI-476295;
CC Q17RB8; O95391: SLU7; NbExp=3; IntAct=EBI-2341787, EBI-750559;
CC Q17RB8; O43597: SPRY2; NbExp=3; IntAct=EBI-2341787, EBI-742487;
CC Q17RB8; O95793: STAU1; NbExp=6; IntAct=EBI-2341787, EBI-358174;
CC Q17RB8; O75558: STX11; NbExp=3; IntAct=EBI-2341787, EBI-714135;
CC Q17RB8; Q5VWN6: TASOR2; NbExp=3; IntAct=EBI-2341787, EBI-745958;
CC Q17RB8; O60806: TBX19; NbExp=3; IntAct=EBI-2341787, EBI-12096770;
CC Q17RB8; Q12933: TRAF2; NbExp=3; IntAct=EBI-2341787, EBI-355744;
CC Q17RB8; P14373: TRIM27; NbExp=3; IntAct=EBI-2341787, EBI-719493;
CC Q17RB8; Q8IWZ5: TRIM42; NbExp=8; IntAct=EBI-2341787, EBI-5235829;
CC Q17RB8; Q9BZR9: TRIM8; NbExp=3; IntAct=EBI-2341787, EBI-2340370;
CC Q17RB8; Q7KZS0: UBE2I; NbExp=3; IntAct=EBI-2341787, EBI-10180829;
CC Q17RB8; O14933: UBE2L6; NbExp=7; IntAct=EBI-2341787, EBI-2129974;
CC Q17RB8; Q99990: VGLL1; NbExp=3; IntAct=EBI-2341787, EBI-11983165;
CC Q17RB8; Q9BRX9: WDR83; NbExp=3; IntAct=EBI-2341787, EBI-7705033;
CC Q17RB8; P98170: XIAP; NbExp=7; IntAct=EBI-2341787, EBI-517127;
CC Q17RB8; Q8TF47: ZFP90; NbExp=3; IntAct=EBI-2341787, EBI-11419867;
CC Q17RB8; Q9BUY5: ZNF426; NbExp=3; IntAct=EBI-2341787, EBI-743265;
CC Q17RB8; Q96CK0: ZNF653; NbExp=3; IntAct=EBI-2341787, EBI-12217757;
CC Q17RB8; Q6NX45: ZNF774; NbExp=3; IntAct=EBI-2341787, EBI-10251462;
CC Q17RB8; Q9UHR6: ZNHIT2; NbExp=3; IntAct=EBI-2341787, EBI-2557592;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q17RB8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q17RB8-2; Sequence=VSP_037971;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI17382.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAI17386.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAB85052.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAG59741.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAG62246.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AC123777; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK074329; BAB85052.1; ALT_FRAME; mRNA.
DR EMBL; AK297266; BAG59741.1; ALT_FRAME; mRNA.
DR EMBL; AK300538; BAG62246.1; ALT_INIT; mRNA.
DR EMBL; BC004538; AAH04538.2; -; mRNA.
DR EMBL; BC117381; AAI17382.1; ALT_INIT; mRNA.
DR EMBL; BC117385; AAI17386.1; ALT_INIT; mRNA.
DR CCDS; CCDS5987.2; -. [Q17RB8-1]
DR RefSeq; NP_001316905.1; NM_001329976.1. [Q17RB8-2]
DR RefSeq; NP_689484.3; NM_152271.4. [Q17RB8-1]
DR AlphaFoldDB; Q17RB8; -.
DR SMR; Q17RB8; -.
DR BioGRID; 124867; 106.
DR IntAct; Q17RB8; 94.
DR STRING; 9606.ENSP00000381298; -.
DR iPTMnet; Q17RB8; -.
DR PhosphoSitePlus; Q17RB8; -.
DR BioMuta; LONRF1; -.
DR DMDM; 257051033; -.
DR EPD; Q17RB8; -.
DR jPOST; Q17RB8; -.
DR MassIVE; Q17RB8; -.
DR MaxQB; Q17RB8; -.
DR PaxDb; Q17RB8; -.
DR PeptideAtlas; Q17RB8; -.
DR PRIDE; Q17RB8; -.
DR ProteomicsDB; 61144; -. [Q17RB8-1]
DR ProteomicsDB; 61145; -. [Q17RB8-2]
DR Antibodypedia; 8694; 116 antibodies from 21 providers.
DR DNASU; 91694; -.
DR Ensembl; ENST00000398246.8; ENSP00000381298.3; ENSG00000154359.13. [Q17RB8-1]
DR GeneID; 91694; -.
DR KEGG; hsa:91694; -.
DR MANE-Select; ENST00000398246.8; ENSP00000381298.3; NM_152271.5; NP_689484.3.
DR UCSC; uc003wwd.2; human. [Q17RB8-1]
DR CTD; 91694; -.
DR DisGeNET; 91694; -.
DR GeneCards; LONRF1; -.
DR HGNC; HGNC:26302; LONRF1.
DR HPA; ENSG00000154359; Low tissue specificity.
DR neXtProt; NX_Q17RB8; -.
DR OpenTargets; ENSG00000154359; -.
DR PharmGKB; PA128394743; -.
DR VEuPathDB; HostDB:ENSG00000154359; -.
DR eggNOG; KOG4159; Eukaryota.
DR GeneTree; ENSGT00440000033329; -.
DR InParanoid; Q17RB8; -.
DR OMA; DWPEVYF; -.
DR OrthoDB; 458276at2759; -.
DR PhylomeDB; Q17RB8; -.
DR TreeFam; TF327043; -.
DR PathwayCommons; Q17RB8; -.
DR Reactome; R-HSA-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR SignaLink; Q17RB8; -.
DR BioGRID-ORCS; 91694; 12 hits in 1112 CRISPR screens.
DR ChiTaRS; LONRF1; human.
DR GenomeRNAi; 91694; -.
DR Pharos; Q17RB8; Tdark.
DR PRO; PR:Q17RB8; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q17RB8; protein.
DR Bgee; ENSG00000154359; Expressed in skin of leg and 96 other tissues.
DR ExpressionAtlas; Q17RB8; baseline and differential.
DR Genevisible; Q17RB8; HS.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR Gene3D; 1.25.40.10; -; 1.
DR Gene3D; 2.30.130.40; -; 1.
DR Gene3D; 3.30.40.10; -; 2.
DR InterPro; IPR003111; Lon_prtase_N.
DR InterPro; IPR046336; Lon_prtase_N_sf.
DR InterPro; IPR015947; PUA-like_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR027370; Znf-RING_LisH.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR Pfam; PF02190; LON_substr_bdg; 1.
DR Pfam; PF13445; zf-RING_UBOX; 1.
DR SMART; SM00464; LON; 1.
DR SMART; SM00184; RING; 2.
DR SMART; SM00028; TPR; 4.
DR SUPFAM; SSF48452; SSF48452; 1.
DR SUPFAM; SSF88697; SSF88697; 1.
DR PROSITE; PS51787; LON_N; 1.
DR PROSITE; PS50293; TPR_REGION; 1.
DR PROSITE; PS00518; ZF_RING_1; 2.
DR PROSITE; PS50089; ZF_RING_2; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Metal-binding; Phosphoprotein; Reference proteome;
KW Repeat; TPR repeat; Zinc; Zinc-finger.
FT CHAIN 1..773
FT /note="LON peptidase N-terminal domain and RING finger
FT protein 1"
FT /id="PRO_0000277669"
FT REPEAT 48..81
FT /note="TPR 1"
FT REPEAT 212..244
FT /note="TPR 2"
FT REPEAT 246..278
FT /note="TPR 3"
FT REPEAT 279..312
FT /note="TPR 4"
FT DOMAIN 565..766
FT /note="Lon N-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01123"
FT ZN_FING 123..159
FT /note="RING-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT ZN_FING 479..517
FT /note="RING-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 359..388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 359..375
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 431
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:D3YY23"
FT VAR_SEQ 452..462
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_037971"
FT VARIANT 265
FT /note="I -> L (in dbSNP:rs1139354)"
FT /id="VAR_058706"
FT CONFLICT 663
FT /note="I -> V (in Ref. 2; BAG62246)"
FT /evidence="ECO:0000305"
FT CONFLICT 773
FT /note="K -> E (in Ref. 2; BAG59741)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 773 AA; 86725 MW; B151BEB07CF3638B CRC64;
MSSPAVARTS PGGSREMAPA PQGRGRFWEV GGGSGHRLER AAAESERWEL LLRRGELLAL
GGHLKGALEA FAAALRRGAP ARPECLGALV DCLVFNYRLR HGLGWSAAPV AGADGGAGGL
LRCLGCRGFL SEPVTVPCGH SYCRRCLRRE LRARCRLCRD RLPPATASAT DAEGTAPRPP
PLAAAIAASD FRTSVVLNHL AEKWFPGQRE RARAAGRLGE LLHQGRYREA LAAACEALRA
EPSDLIVKIY RAESYAGLQE FKAAIEDLNA VLFQLPDWPE VYFRKGKVLC DAGFLGDALQ
LFLQCLALDE DFAPAKLQVQ KILCDLLLPE NLKEGLKESS WSSLPCTKNR PFDFHSVMEE
SQSLNEPSPK QSEEIPEVTS EPVKGSLNRA QSAQSINSTE MPAREDCLKR VSSEPVLSVQ
EKGVLLKRKL SLLEQDVIVN EDGRNKLKKQ GETPNEVCMF SLAYGDIPEE LIDVSDFECS
LCMRLFFEPV TTPCGHSFCK NCLERCLDHA PYCPLCKESL KEYLADRRYC VTQLLEELIV
KYLPDELSER KKIYDEETAE LSHLTKNVPI FVCTMAYPTV PCPLHVFEPR YRLMIRRSIQ
TGTKQFGMCV SDTQNSFADY GCMLQIRNVH FLPDGRSVVD TVGGKRFRVL KRGMKDGYCT
ADIEYLEDVK VENEDEIKNL RELHDLVYSQ ACSWFQNLRD RFRSQILQHF GSMPEREENL
QAAPNGPAWC WWLLAVLPVD PRYQLSVLSM KSLKERLTKI QHILTYFSRD QSK
