LONF1_MOUSE
ID LONF1_MOUSE Reviewed; 762 AA.
AC D3YY23;
DT 11-MAY-2016, integrated into UniProtKB/Swiss-Prot.
DT 11-MAY-2016, sequence version 2.
DT 03-AUG-2022, entry version 84.
DE RecName: Full=LON peptidase N-terminal domain and RING finger protein 1;
GN Name=Lonrf1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-420, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
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DR EMBL; AC153007; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS40321.2; -.
DR AlphaFoldDB; D3YY23; -.
DR SMR; D3YY23; -.
DR IntAct; D3YY23; 1.
DR STRING; 10090.ENSMUSP00000066403; -.
DR iPTMnet; D3YY23; -.
DR PhosphoSitePlus; D3YY23; -.
DR PaxDb; D3YY23; -.
DR PRIDE; D3YY23; -.
DR ProteomicsDB; 286227; -.
DR Antibodypedia; 8694; 116 antibodies from 21 providers.
DR Ensembl; ENSMUST00000239119; ENSMUSP00000158932; ENSMUSG00000039633.
DR UCSC; uc009llj.1; mouse.
DR MGI; MGI:3609241; Lonrf1.
DR VEuPathDB; HostDB:ENSMUSG00000039633; -.
DR eggNOG; KOG4159; Eukaryota.
DR GeneTree; ENSGT00440000033329; -.
DR HOGENOM; CLU_013989_1_1_1; -.
DR InParanoid; D3YY23; -.
DR TreeFam; TF327043; -.
DR Reactome; R-MMU-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR ChiTaRS; Lonrf1; mouse.
DR PRO; PR:D3YY23; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; D3YY23; protein.
DR Bgee; ENSMUSG00000039633; Expressed in otolith organ and 219 other tissues.
DR ExpressionAtlas; D3YY23; baseline and differential.
DR Genevisible; D3YY23; MM.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR Gene3D; 1.25.40.10; -; 1.
DR Gene3D; 2.30.130.40; -; 1.
DR Gene3D; 3.30.40.10; -; 2.
DR InterPro; IPR003111; Lon_prtase_N.
DR InterPro; IPR046336; Lon_prtase_N_sf.
DR InterPro; IPR015947; PUA-like_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR027370; Znf-RING_LisH.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR Pfam; PF02190; LON_substr_bdg; 1.
DR Pfam; PF13445; zf-RING_UBOX; 1.
DR SMART; SM00464; LON; 1.
DR SMART; SM00184; RING; 2.
DR SMART; SM00028; TPR; 4.
DR SUPFAM; SSF48452; SSF48452; 1.
DR SUPFAM; SSF88697; SSF88697; 1.
DR PROSITE; PS51787; LON_N; 1.
DR PROSITE; PS50293; TPR_REGION; 1.
DR PROSITE; PS00518; ZF_RING_1; 2.
DR PROSITE; PS50089; ZF_RING_2; 2.
PE 1: Evidence at protein level;
KW Metal-binding; Phosphoprotein; Reference proteome; Repeat; TPR repeat;
KW Zinc; Zinc-finger.
FT CHAIN 1..762
FT /note="LON peptidase N-terminal domain and RING finger
FT protein 1"
FT /id="PRO_0000436226"
FT REPEAT 47..80
FT /note="TPR 1"
FT /evidence="ECO:0000255"
FT REPEAT 201..233
FT /note="TPR 2"
FT /evidence="ECO:0000255"
FT REPEAT 235..267
FT /note="TPR 3"
FT /evidence="ECO:0000255"
FT REPEAT 268..301
FT /note="TPR 4"
FT /evidence="ECO:0000255"
FT DOMAIN 554..755
FT /note="Lon N-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01123"
FT ZN_FING 118..154
FT /note="RING-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT ZN_FING 468..506
FT /note="RING-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 420
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
SQ SEQUENCE 762 AA; 85106 MW; D58560C72A1CB7C0 CRC64;
MSSPAVARAS PGGNREASGG PRSRNGPWEV GGGGERLERA GAESGRWELL LRRGELLALG
GHLKGALEAF AAALRRGAPA RPERLGSLVD CLVFSYRLRH GLRWSAAPAA GAAGLLSCLS
CRGFLSEPVT VPCGHSYCRR CLRRELRARC RLCRDRLPPA AAASEGTPRP PPLAAAIADF
RTSVVLNHLA EKWFPGQRER ARAAGRLGEL LHEGRYREAL AAACDALRAE PSDLTLKIYR
AESYAGLQEF KAALEDLNAV LFQLPNWPEV YFRKGKVLQD AGFLGDALQL FLQCLALDED
FAPAKLQVEK ILCDLLSPEN VREGLKESSW SSLPCIKSKP LGFPSVMEQP HSPAELGLKQ
PEERVEDAPE PVKGSLSRAQ SAQAISAAAV PAREDGLKRV CSEPLLSAQG KGVLLKRKLS
LLEQDVLINE DGRSKLKKQS ESPSEDCMFS IAYGDIPEEL IDVSDFECSL CMRLFFEPVT
TPCGHSFCKN CLERCLDHAP YCPLCKESLK EYLADRRYCV TQLLEELIVK YLPDELSERK
KIYDEETAEL SHLTKNVPIF VCTMAYPTVP CPLHVFEPRY RLMIRRSIQT GTKQFGMCVS
DTQNSFADYG CMLQIRNVHF LPDGRSVVDT VGGKRFRVLK RGMKDGYCTA DIEYLEDVKI
ENGDEIRSLR ELHDSVYSQA CSWFQNLRDR FRSQILQHFG SMPEREENLQ ATPNGPAWCW
WLLAVLPVDP RYQLSVLSMK SLEERLTKIQ HILTYFSRDQ SK
