ID   LONF3_MACFA             Reviewed;         718 AA.
AC   Q8HXH0;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=LON peptidase N-terminal domain and RING finger protein 3;
GN   Name=LONRF3; ORFNames=QmoA-15092;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Medulla oblongata;
RA   Osada N., Hida M., Kusuda J., Tanuma R., Iseki K., Hirai M., Terao K.,
RA   Suzuki Y., Sugano S., Hashimoto K.;
RT   "Isolation of full-length cDNA clones from macaque brain cDNA libraries.";
RL   Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; AB097555; BAC41780.1; -; mRNA.
DR   RefSeq; XP_005594504.1; XM_005594447.2.
DR   AlphaFoldDB; Q8HXH0; -.
DR   SMR; Q8HXH0; -.
DR   GeneID; 102135813; -.
DR   KEGG; mcf:102135813; -.
DR   CTD; 79836; -.
DR   VEuPathDB; HostDB:ENSMFAG00000043034; -.
DR   eggNOG; KOG1124; Eukaryota.
DR   eggNOG; KOG4159; Eukaryota.
DR   Proteomes; UP000233100; Chromosome X.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.10; -; 1.
DR   Gene3D; 2.30.130.40; -; 1.
DR   Gene3D; 3.30.40.10; -; 2.
DR   InterPro; IPR003111; Lon_prtase_N.
DR   InterPro; IPR046336; Lon_prtase_N_sf.
DR   InterPro; IPR015947; PUA-like_sf.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   InterPro; IPR027370; Znf-RING_LisH.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   Pfam; PF02190; LON_substr_bdg; 1.
DR   Pfam; PF13445; zf-RING_UBOX; 1.
DR   SMART; SM00464; LON; 1.
DR   SMART; SM00184; RING; 2.
DR   SMART; SM00028; TPR; 3.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   SUPFAM; SSF88697; SSF88697; 1.
DR   PROSITE; PS51787; LON_N; 1.
DR   PROSITE; PS50005; TPR; 2.
DR   PROSITE; PS50293; TPR_REGION; 1.
DR   PROSITE; PS00518; ZF_RING_1; 2.
DR   PROSITE; PS50089; ZF_RING_2; 2.
PE   2: Evidence at transcript level;
KW   Metal-binding; Reference proteome; Repeat; TPR repeat; Zinc; Zinc-finger.
FT   CHAIN           1..718
FT                   /note="LON peptidase N-terminal domain and RING finger
FT                   protein 3"
FT                   /id="PRO_0000277672"
FT   REPEAT          67..100
FT                   /note="TPR 1"
FT   REPEAT          243..276
FT                   /note="TPR 2"
FT   REPEAT          278..310
FT                   /note="TPR 3"
FT   DOMAIN          512..712
FT                   /note="Lon N-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01123"
FT   ZN_FING         158..196
FT                   /note="RING-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT   ZN_FING         426..464
FT                   /note="RING-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT   REGION          1..69
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          322..413
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..25
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        55..69
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        342..364
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   718 AA;  79790 MW;  7875DC66B87B0B51 CRC64;
     MESLRTEQML SLPAEVSSNN LEPAERGASA AQVDMGPHRE AAAESPAPLP TREPEQEQSP
     GTSTPESKVL LTQADALASR GRIREALEVY RQLSERQQLV AEQLEQLVRC LAEKVPQGEA
     LAPAPPGEGS TASGAVAAEE TGAAAAAAAT EVWDGFKCRK CHGFLSDPVS LSCGHTFCKL
     CLERGRAADR RCALCGVKLS ALMVATGRAR GSRRAGQQPP PPLRVNVVLS GLLGKLFPGP
     ARASQLRHEG NRLYRERQVE AALLKYNEAV KLAPNDHLLY SNRSQIYFTL ESHENALHDA
     EIACKLRPMG FKDNLELPHC SSQEEAAARG DGSSLMDPAK VKGDGQQHHM KDQEEEEEKW
     DATSPKAASS KTGKCQEKKR KHCQIESQED TGMPNKASKQ DPPTDQGDKP ALSLPLASFD
     ASDLECALCM RLFYEPVTTP CGHTFCLKCL ERCLDHNAKC PLCKDGLSQC LASRKYSKNV
     IMEELIAKFL PEELKERRKL YEEEMEELSN LNKNVPIFVC TMAYPTVPCP LHIFEPCYRL
     MIRRCIETGT RQFGMCLGDP VKGFAEYGCI LEIRNVQFFA DGRSVVDSIG KRRFRVLHQS
     QRDGYNTADI EYIEDQKVQG EDCAELMGLH NCVYQQASLW FHSLKSSLKN RILNHFGPMP
     EKDADPQMNP NGPAWCWWML AVLPLESRAQ LPFLAMRSLK DRLNGIRRVL AFISRNQN