LONH_ECOLI
ID LONH_ECOLI Reviewed; 586 AA.
AC P75867;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Putative Lon protease homolog;
DE EC=3.4.21.-;
DE AltName: Full=ATP-dependent protease La homolog;
GN Name=ycbZ; OrderedLocusNames=b0955, JW0938;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=8905232; DOI=10.1093/dnares/3.3.137;
RA Oshima T., Aiba H., Baba T., Fujita K., Hayashi K., Honjo A., Ikemoto K.,
RA Inada T., Itoh T., Kajihara M., Kanai K., Kashimoto K., Kimura S.,
RA Kitagawa M., Makino K., Masuda S., Miki T., Mizobuchi K., Mori H.,
RA Motomura K., Nakamura Y., Nashimoto H., Nishio Y., Saito N., Sampei G.,
RA Seki Y., Tagami H., Takemoto K., Wada C., Yamamoto Y., Yano M.,
RA Horiuchi T.;
RT "A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT the 12.7-28.0 min region on the linkage map.";
RL DNA Res. 3:137-155(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
CC -!- DOMAIN: Lacks the ATP-binding domain.
CC -!- SIMILARITY: Belongs to the peptidase S16 family. {ECO:0000255|PROSITE-
CC ProRule:PRU01122}.
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DR EMBL; U00096; AAC74041.1; -; Genomic_DNA.
DR EMBL; AP009048; BAA35713.1; -; Genomic_DNA.
DR PIR; B64836; B64836.
DR RefSeq; NP_415475.1; NC_000913.3.
DR RefSeq; WP_000156518.1; NZ_LN832404.1.
DR AlphaFoldDB; P75867; -.
DR SMR; P75867; -.
DR BioGRID; 4260030; 40.
DR DIP; DIP-11487N; -.
DR STRING; 511145.b0955; -.
DR MEROPS; S16.A10; -.
DR jPOST; P75867; -.
DR PaxDb; P75867; -.
DR PRIDE; P75867; -.
DR EnsemblBacteria; AAC74041; AAC74041; b0955.
DR EnsemblBacteria; BAA35713; BAA35713; BAA35713.
DR GeneID; 945569; -.
DR KEGG; ecj:JW0938; -.
DR KEGG; eco:b0955; -.
DR PATRIC; fig|1411691.4.peg.1319; -.
DR EchoBASE; EB3482; -.
DR eggNOG; COG1067; Bacteria.
DR InParanoid; P75867; -.
DR OMA; GFFTICQ; -.
DR PhylomeDB; P75867; -.
DR BioCyc; EcoCyc:G6493-MON; -.
DR PRO; PR:P75867; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004176; F:ATP-dependent peptidase activity; IEA:InterPro.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0030163; P:protein catabolic process; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR041699; AAA_32.
DR InterPro; IPR008269; Lon_proteolytic.
DR InterPro; IPR027065; Lon_Prtase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR PANTHER; PTHR10046; PTHR10046; 1.
DR Pfam; PF13654; AAA_32; 1.
DR Pfam; PF05362; Lon_C; 1.
DR SUPFAM; SSF54211; SSF54211; 1.
DR PROSITE; PS51786; LON_PROTEOLYTIC; 1.
PE 3: Inferred from homology;
KW Hydrolase; Protease; Reference proteome; Serine protease.
FT CHAIN 1..586
FT /note="Putative Lon protease homolog"
FT /id="PRO_0000076148"
FT DOMAIN 346..543
FT /note="Lon proteolytic"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01122"
FT ACT_SITE 438
FT /evidence="ECO:0000250"
FT ACT_SITE 481
FT /evidence="ECO:0000250"
SQ SEQUENCE 586 AA; 65819 MW; 442AAEADDB87B59F CRC64;
MTITKLAWRD LVPDTDSYQE IFAQPHLIDE NDPLFSDTQP RLQFALEQLL HTRASSSFML
AKAPEESEYL NLIANAARTL QSDAGQLVGG HYEVSGHSIR LRHAVSADDN FATLTQVVAA
DWVEAEQLFG CLRQFNGDIT LQPGLVHQAN GGILIISLRT LLAQPLLWMR LKNIVNRERF
DWVAFDESRP LPVSVPSMPL KLKVILVGER ESLADFQEME PELSEQAIYS EFEDTLQIVD
AESVTQWCRW VTFTARHNHL PAPGADAWPI LIREAARYTG EQETLPLSPQ WILRQCKEVA
SLCDGDTFSG EQLNLMLQQR EWREGFLAER MQDEILQEQI LIETEGERIG QINALSVIEF
PGHPRAFGEP SRISCVVHIG DGEFTDIERK AELGGNIHAK GMMIMQAFLM SELQLEQQIP
FSASLTFEQS YSEVDGDSAS MAELCALISA LADVPVNQSI AITGSVDQFG RAQPVGGLNE
KIEGFFAICQ QRELTGKQGV IIPTANVRHL SLHSELVKAV EEGKFTIWAV DDVTDALPLL
LNLVWDGEGQ TTLMQTIQER IAQASQQEGR HRFPWPLRWL NWFIPN
