ID   LONH_HAEIN              Reviewed;         601 AA.
AC   P43865;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Putative Lon protease homolog;
DE            EC=3.4.21.-;
DE   AltName: Full=ATP-dependent protease La homolog;
GN   OrderedLocusNames=HI_1324;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- DOMAIN: Lacks the ATP-binding domain.
CC   -!- SIMILARITY: Belongs to the peptidase S16 family. {ECO:0000255|PROSITE-
CC       ProRule:PRU01122}.
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DR   EMBL; L42023; AAC22971.1; -; Genomic_DNA.
DR   PIR; F64116; F64116.
DR   RefSeq; NP_439475.1; NC_000907.1.
DR   AlphaFoldDB; P43865; -.
DR   SMR; P43865; -.
DR   STRING; 71421.HI_1324; -.
DR   MEROPS; S16.A10; -.
DR   EnsemblBacteria; AAC22971; AAC22971; HI_1324.
DR   KEGG; hin:HI_1324; -.
DR   PATRIC; fig|71421.8.peg.1376; -.
DR   eggNOG; COG1067; Bacteria.
DR   HOGENOM; CLU_014785_2_0_6; -.
DR   OMA; GFFTICQ; -.
DR   PhylomeDB; P43865; -.
DR   BioCyc; HINF71421:G1GJ1-1349-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004176; F:ATP-dependent peptidase activity; IEA:InterPro.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0030163; P:protein catabolic process; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR041699; AAA_32.
DR   InterPro; IPR008269; Lon_proteolytic.
DR   InterPro; IPR027065; Lon_Prtase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR008268; Peptidase_S16_AS.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10046; PTHR10046; 1.
DR   Pfam; PF13654; AAA_32; 1.
DR   Pfam; PF05362; Lon_C; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   PROSITE; PS51786; LON_PROTEOLYTIC; 1.
DR   PROSITE; PS01046; LON_SER; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Protease; Reference proteome; Serine protease.
FT   CHAIN           1..601
FT                   /note="Putative Lon protease homolog"
FT                   /id="PRO_0000076149"
FT   DOMAIN          363..560
FT                   /note="Lon proteolytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01122"
FT   ACT_SITE        455
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10087"
FT   ACT_SITE        498
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10087"
SQ   SEQUENCE   601 AA;  67570 MW;  14B8DB4941DF49F5 CRC64;
     MVNFSRKRPA VSSLFSQQQA IEQSLNWQAL QPDLVIQDFP LEPVNFWALQ PNATQGIDLF
     LRHPTRSLLM MKVGEPVEYA ELLQNFISQN HHKVRSIFGV NYVIEQGDSF SFPHVYTEPA
     KSLDDNFASQ GEALSALYCD QFQLFGSFRI HPRSQDIQLV PGLVHKANGG VLILSAATLL
     SQFDLWGRLK QILQTQTFDW YSAHPFKNLP CDIPSYALNL KVIVLGNRTE LATLAELEEN
     LYSFADYAEI ESYISVAEVE EQKTWAGYVQ QMAQEQNIEL DFLALNKLYQ LLVRESENRF
     LINASPLKLK EILQDASTFT EKTALSAVDF EGIFQQKLAQ YGFLKEQTYA DILNEQVYVE
     TQGEIVGQIN GLSVIEYPGT PVCFGEPSRI SCIVQFGDGE VIDVERKNEL AGNIHGKGMM
     IAQACLSNIL DLPSQLPFSA SLVFEQSYGE IDGDSASLAI FCVLVSALAD LPLPQHIAIT
     GSIDQFGLVH SVGGVNDKIE GFFTICQRRG LTGKQGVIIP MTTIQQLSLS DDVKSAVKNG
     EFFIYPVEDI YQACELLFGR DLLDENKDYT EKTESLSRLI QRRIEGRADS ERKSFWHFFR
     S