ID   LONH_THEAC              Reviewed;         493 AA.
AC   Q9HLX6;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Putative lon protease homolog;
DE            EC=3.4.21.-;
DE   AltName: Full=ATP-dependent protease La homolog;
GN   OrderedLocusNames=Ta0098;
OS   Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC
OS   15155 / AMRC-C165).
OC   Archaea; Candidatus Thermoplasmatota; Thermoplasmata; Thermoplasmatales;
OC   Thermoplasmataceae; Thermoplasma.
OX   NCBI_TaxID=273075;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165;
RX   PubMed=11029001; DOI=10.1038/35035069;
RA   Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C.,
RA   Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W.;
RT   "The genome sequence of the thermoacidophilic scavenger Thermoplasma
RT   acidophilum.";
RL   Nature 407:508-513(2000).
CC   -!- SIMILARITY: Belongs to the peptidase S16 family. {ECO:0000305}.
CC   -!- CAUTION: Lacks the conserved Ser-Lys catalytic dyad essential for
CC       proteolytic activity. Its enzyme activity is therefore unsure.
CC       {ECO:0000305}.
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DR   EMBL; AL445063; CAC11246.1; -; Genomic_DNA.
DR   RefSeq; WP_010900525.1; NC_002578.1.
DR   AlphaFoldDB; Q9HLX6; -.
DR   SMR; Q9HLX6; -.
DR   STRING; 273075.Ta0098; -.
DR   EnsemblBacteria; CAC11246; CAC11246; CAC11246.
DR   GeneID; 1455754; -.
DR   KEGG; tac:Ta0098; -.
DR   eggNOG; arCOG02162; Archaea.
DR   HOGENOM; CLU_550564_0_0_2; -.
DR   OMA; HDPYGGH; -.
DR   OrthoDB; 7657at2157; -.
DR   Proteomes; UP000001024; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004176; F:ATP-dependent peptidase activity; IEA:InterPro.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0030163; P:protein catabolic process; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR041699; AAA_32.
DR   InterPro; IPR027065; Lon_Prtase.
DR   InterPro; IPR000523; Mg_chelatse_chII-like_cat_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR002078; Sigma_54_int.
DR   PANTHER; PTHR10046; PTHR10046; 2.
DR   Pfam; PF13654; AAA_32; 1.
DR   Pfam; PF01078; Mg_chelatase; 1.
DR   Pfam; PF00158; Sigma54_activat; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Hydrolase; Nucleotide-binding; Protease; Reference proteome;
KW   Serine protease.
FT   CHAIN           1..493
FT                   /note="Putative lon protease homolog"
FT                   /id="PRO_0000076157"
FT   BINDING         52..59
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   493 AA;  55536 MW;  FE947CFBA09DB538 CRC64;
     MGTFFVDFYN EYPDTSYIKI PTNPLDRVIG QDDAVKIAMV AAKQRRHLLL VGPPGVGKSM
     IAQAMSFYID RPTEEIRVVH NPQYPERPFV EIKTREEVMA EREEETSTSG IIIDPKDAPT
     SVAERLGYRC SKCGFYSSPS DAVCPNCNSP KIQMGTQGPF GDVFNVIGAA FGVQNNLDKV
     TLTRRNGDHD EIIVYERYND KIRVLDEKTL ERRRRLEKKS PSKTIVPIDR NPFVLATGAS
     ETELLGDVRH DPYGGHPQLG TLPYERVIAG AVHEAHQGVL FIDEITHLGN LQRYILTAMQ
     EKTFPITGRN PQSAGASVRV DKVPADFILV AACNINDLPY ILSPLRSRIV GNGYEILMKT
     TMKDTDENRM KYLQFISQEI TMDGKIPHMT MEAAELIIEE GKKRARIIDK KNNELTLRLR
     ELGGLIRAAG DIAVFKGNKL IEKEDVEEAI KLYVPVEEKI TKEYGSMAAA YSSENTTSQK
     DFYNYNLDDR SYE