LORI_MOUSE
ID LORI_MOUSE Reviewed; 486 AA.
AC P18165; Q8R0I9;
DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2004, sequence version 2.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Loricrin {ECO:0000305};
GN Name=Loricrin; Synonyms=Lor;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2190691; DOI=10.1016/0092-8674(90)90073-n;
RA Mehrel T., Hohl D., Rothnagel J.A., Longley M.A., Bundman D., Cheng C.,
RA Lichti U., Bisher M.E., Steven A.C., Steinart P.M., Yuspa S.H., Roop D.R.;
RT "Identification of a major keratinocyte cell envelope protein, loricrin.";
RL Cell 61:1103-1112(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=BALB/cJ;
RX PubMed=7738016; DOI=10.1074/jbc.270.18.10792;
RA DiSepio D., Jones A., Longley M.A., Bundman D., Rothnagel J.A., Roop D.R.;
RT "The proximal promoter of the mouse loricrin gene contains a functional AP-
RT 1 element and directs keratinocyte-specific but not differentiation-
RT specific expression.";
RL J. Biol. Chem. 270:10792-10799(1995).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Olfactory epithelium, and Salivary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=24751727; DOI=10.1038/jid.2014.197;
RA Fischer H., Langbein L., Reichelt J., Praetzel-Wunder S., Buchberger M.,
RA Ghannadan M., Tschachler E., Eckhart L.;
RT "Loss of keratin K2 expression causes aberrant aggregation of K10,
RT hyperkeratosis, and inflammation.";
RL J. Invest. Dermatol. 134:2579-2588(2014).
RN [5]
RP MUTANT FORM.
RX PubMed=11038186; DOI=10.1083/jcb.151.2.401;
RA Suga Y., Jarnik M., Attar P.S., Longley M.A., Bundman D., Steven A.C.,
RA Koch P.J., Roop D.R.;
RT "Transgenic mice expressing a mutant form of loricrin reveal the molecular
RT basis of the skin diseases, Vohwinkel syndrome and progressive symmetric
RT erythrokeratoderma.";
RL J. Cell Biol. 151:401-412(2000).
RN [6]
RP DEVELOPMENTAL STAGE.
RX PubMed=32758484; DOI=10.1016/j.ydbio.2020.07.016;
RA Simonson L., Vold S., Mowers C., Massey R.J., Ong I.M., Longley B.J.,
RA Chang H.;
RT "Keratin 13 deficiency causes white sponge nevus in mice.";
RL Dev. Biol. 468:146-153(2020).
CC -!- FUNCTION: Major keratinocyte cell envelope protein.
CC -!- TISSUE SPECIFICITY: Expressed in the epidermis of the ear (at protein
CC level). {ECO:0000269|PubMed:24751727}.
CC -!- DEVELOPMENTAL STAGE: Expressed in the spinous and granular layers of
CC the tongue at P20. {ECO:0000269|PubMed:32758484}.
CC -!- PTM: Substrate of transglutaminases. Some glutamines and lysines are
CC cross-linked to other loricrin molecules and to SPRRs proteins.
CC -!- PTM: Contains inter- or intramolecular disulfide-bonds. {ECO:0000250}.
CC -!- MISCELLANEOUS: Transgenic mice expressing a C-terminal truncated form
CC of loricrin exhibited, at birth, erythrokeratoderma with an epidermal
CC barrier dysfunction. 4 days after birth, high-expressing transgenic
CC animals showed a generalized scaling of the skin, as well as a
CC constricting band encircling the tail and, by day 7, a thickening of
CC the footpads. Transgenic mice also showed retention of nuclei in the
CC stratum corneum. The mutant loricrin protein is found in the nucleus
CC and cytoplasm of epidermal keratinocytes, but is not detect in the
CC cornified cell envelope. The C-terminal domain of the mutant loricrin
CC contains a nuclear localization signal.
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DR EMBL; M34398; AAA39444.1; -; mRNA.
DR EMBL; U09189; AAA82152.1; -; Genomic_DNA.
DR EMBL; BC026781; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC058223; AAH58223.1; -; mRNA.
DR CCDS; CCDS17546.1; -.
DR PIR; A35628; A35628.
DR RefSeq; NP_032534.2; NM_008508.2.
DR AlphaFoldDB; P18165; -.
DR STRING; 10090.ENSMUSP00000052128; -.
DR iPTMnet; P18165; -.
DR PhosphoSitePlus; P18165; -.
DR MaxQB; P18165; -.
DR PaxDb; P18165; -.
DR PRIDE; P18165; -.
DR ProteomicsDB; 286229; -.
DR Ensembl; ENSMUST00000058150; ENSMUSP00000052128; ENSMUSG00000043165.
DR GeneID; 16939; -.
DR KEGG; mmu:16939; -.
DR UCSC; uc008qdk.1; mouse.
DR CTD; 16939; -.
DR MGI; MGI:96816; Lor.
DR VEuPathDB; HostDB:ENSMUSG00000043165; -.
DR eggNOG; ENOG502RU07; Eukaryota.
DR GeneTree; ENSGT00950000183801; -.
DR HOGENOM; CLU_609128_0_0_1; -.
DR OMA; GQHYQCQ; -.
DR BioGRID-ORCS; 16939; 1 hit in 71 CRISPR screens.
DR PRO; PR:P18165; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; P18165; protein.
DR Bgee; ENSMUSG00000043165; Expressed in skin of external ear and 181 other tissues.
DR Genevisible; P18165; MM.
DR GO; GO:0001533; C:cornified envelope; IDA:MGI.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0009898; C:cytoplasmic side of plasma membrane; IDA:MGI.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; IDA:MGI.
DR GO; GO:0030280; F:structural constituent of skin epidermis; IDA:MGI.
DR GO; GO:0031424; P:keratinization; IEA:UniProtKB-KW.
DR GO; GO:0030216; P:keratinocyte differentiation; ISO:MGI.
DR GO; GO:0018149; P:peptide cross-linking; ISO:MGI.
PE 1: Evidence at protein level;
KW Disulfide bond; Keratinization; Reference proteome; Repeat.
FT CHAIN 1..486
FT /note="Loricrin"
FT /id="PRO_0000084459"
FT REGION 451..486
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 470..486
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 21..25
FT /note="Missing (in Ref. 1 and 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 257
FT /note="S -> T (in Ref. 1 and 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 293
FT /note="R -> G (in Ref. 1 and 2)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 486 AA; 38200 MW; 652F1BF51E37F171 CRC64;
MSHQKKQPTP CPPVGCGKTS GGGGGGGGGG GGGYYSGGGS GCGGGSSGGG SSCGGGGGGS
YGGGSSCGGG GGSGGGVKYS GGGGGSSCGG GYSGGGGGSS CGGGYSGGGG GSSCGGGYSG
GGGGSSCGGG SYSGGGSSCG GGGGSGGGVK YSGGGGGGGS SCGGGSSGGG GGGSSCGGGS
GGGGSYCGGS SGGGSSGGCG GGSGGGKYSG GGGGSSCGGG YSGGGGSSGG SSCGGGYSGG
GGSSCGGGGG YSGGGGSSCG GGSSGGGGGG SSQQYQCQSY GGGSSGGSSC GGRYSGGGGS
SCGGGYSGGG GSSCGGGSSG GGSSCGGSGG GGYSGGGGGS CGGGSSGGGG GYYSSQQTSQ
TSCAPQQSYG GGSSGGGGSC GGGSSGGGGG GGCYSSGGGG SSGGCGGGYS GGGGGCGGGS
SGGSGGGCGG GSSGGSGGGC GGGYSGGGGG GSSCGGGSSG GGSGGGKGVP VCHQTQQKQA
PTWPCK
