LOT5_YEAST
ID LOT5_YEAST Reviewed; 306 AA.
AC P34234; D6VX18;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Protein LOT5;
DE AltName: Full=Low temperature-responsive protein 5;
GN Name=LOT5; OrderedLocusNames=YKL183W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8154185; DOI=10.1002/yea.320091208;
RA Wiemann S., Voss H., Schwager C., Rupp T., Stegemann J., Zimmermann J.,
RA Grothues D., Sensen C., Erfle H., Hewitt N., Banrevi A., Ansorge W.;
RT "Sequencing and analysis of 51.6 kilobases on the left arm of chromosome XI
RT from Saccharomyces cerevisiae reveals 23 open reading frames including the
RT FAS1 gene.";
RL Yeast 9:1343-1348(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8196765; DOI=10.1038/369371a0;
RA Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V.,
RA Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P.,
RA Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L.,
RA Daignan-Fornier B., del Rey F., Dion C., Domdey H., Duesterhoeft A.,
RA Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H.,
RA Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L.,
RA Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M.,
RA Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H.,
RA Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J.,
RA Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H.,
RA Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J.,
RA Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S.,
RA Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F.,
RA Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R.,
RA Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W.,
RA Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M.,
RA Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C.,
RA Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H.,
RA Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L.,
RA van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S.,
RA von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M.,
RA Becker I., Mewes H.-W.;
RT "Complete DNA sequence of yeast chromosome XI.";
RL Nature 369:371-378(1994).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP INDUCTION.
RX PubMed=11327734; DOI=10.1006/bbrc.2001.4776;
RA Zhang L., Ohta A., Horiuchi H., Takagi M., Imai R.;
RT "Multiple mechanisms regulate expression of low temperature responsive
RT (LOT) genes in Saccharomyces cerevisiae.";
RL Biochem. Biophys. Res. Commun. 283:531-535(2001).
RN [5]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [6]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus
CC {ECO:0000269|PubMed:14562095}.
CC -!- INDUCTION: By cold. {ECO:0000269|PubMed:11327734}.
CC -!- MISCELLANEOUS: Present with 5930 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the LOT5 family. {ECO:0000305}.
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DR EMBL; X74151; CAA52255.1; -; Genomic_DNA.
DR EMBL; Z28183; CAA82026.1; -; Genomic_DNA.
DR EMBL; BK006944; DAA08984.1; -; Genomic_DNA.
DR PIR; S34687; S34687.
DR RefSeq; NP_012738.1; NM_001179749.1.
DR AlphaFoldDB; P34234; -.
DR BioGRID; 33939; 26.
DR DIP; DIP-1413N; -.
DR IntAct; P34234; 3.
DR MINT; P34234; -.
DR STRING; 4932.YKL183W; -.
DR MaxQB; P34234; -.
DR PaxDb; P34234; -.
DR PRIDE; P34234; -.
DR EnsemblFungi; YKL183W_mRNA; YKL183W; YKL183W.
DR GeneID; 853652; -.
DR KEGG; sce:YKL183W; -.
DR SGD; S000001666; LOT5.
DR VEuPathDB; FungiDB:YKL183W; -.
DR eggNOG; ENOG502RY1I; Eukaryota.
DR HOGENOM; CLU_073622_0_0_1; -.
DR InParanoid; P34234; -.
DR OMA; NSCIIIW; -.
DR BioCyc; YEAST:G3O-31947-MON; -.
DR PRO; PR:P34234; -.
DR Proteomes; UP000002311; Chromosome XI.
DR RNAct; P34234; protein.
DR GO; GO:0005737; C:cytoplasm; HDA:SGD.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; HDA:SGD.
DR GO; GO:0005681; C:spliceosomal complex; IBA:GO_Central.
DR GO; GO:0045292; P:mRNA cis splicing, via spliceosome; IBA:GO_Central.
DR InterPro; IPR039924; ICln/Lot5/Saf5.
DR PANTHER; PTHR21399; PTHR21399; 1.
DR Pfam; PF03517; Voldacs; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Nucleus; Reference proteome.
FT CHAIN 1..306
FT /note="Protein LOT5"
FT /id="PRO_0000203137"
SQ SEQUENCE 306 AA; 34326 MW; 4EF3CD0C7D4DF14D CRC64;
MMKKKPKCQI ARTKPSVENV IPYNQFKKTQ PRFNGNFSAL NNEEYIILFG GGRDLILGSL
TPCSSSHLSN QANPQDTSEY GTDLFILNSC IIIWFNGLGY GLEIPYSSVL YHASRRLPDG
REGLQLEILL TLERDEVLDM LYQSLAPQAC EFDGEEAHAF TVRSVELTIR PKYSIYDRHY
NNEIETLFTF ENFGVNRGDD LVNNCNEALA VCMDLHGEDV QDQDQEQYQD PSMAFEGAQD
LNATYSGLGD TLHGPPVYQN DGLADDLDGD LVMDNVVSRG GPEASMSMEF YANQNLAGRK
NSRDNE
