LOV1A_ARATH
ID LOV1A_ARATH Reviewed; 727 AA.
AC O04093;
DT 11-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT 08-MAR-2011, sequence version 3.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Putative inactive disease susceptibility protein LOV1;
DE AltName: Full=Disease resistance protein RPP8-like protein 1;
DE AltName: Full=Protein LONG VEGETATIVE PHASE1;
GN Name=LOV1; Synonyms=RPP8L1; OrderedLocusNames=At1g10920;
GN ORFNames=T19D16.16;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-322.
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP IDENTIFICATION OF FRAMESHIFT AND STOP CODON.
RC STRAIN=cv. Cl-0;
RX PubMed=17804803; DOI=10.1073/pnas.0702572104;
RA Lorang J.M., Sweat T.A., Wolpert T.J.;
RT "Plant disease susceptibility conferred by a 'resistance' gene.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:14861-14866(2007).
RN [5]
RP IDENTIFICATION OF FRAMESHIFT AND STOP CODON.
RC STRAIN=cv. Col-4;
RX PubMed=18052878; DOI=10.1094/mpmi-21-1-0007;
RA Sweat T.A., Lorang J.M., Bakker E.G., Wolpert T.J.;
RT "Characterization of natural and induced variation in the LOV1 gene, a CC-
RT NB-LRR gene conferring victorin sensitivity and disease susceptibility in
RT Arabidopsis.";
RL Mol. Plant Microbe Interact. 21:7-19(2008).
RN [6]
RP INDUCTION BY EMF1 AND EMF2.
RX PubMed=19783648; DOI=10.1104/pp.109.143495;
RA Kim S.Y., Zhu T., Sung Z.R.;
RT "Epigenetic regulation of gene programs by EMF1 and EMF2 in Arabidopsis.";
RL Plant Physiol. 152:516-528(2010).
CC -!- INDUCTION: Repressed by silencing mediated by polycomb group (PcG)
CC protein complex containing EMF1 and EMF2.
CC {ECO:0000269|PubMed:19783648}.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family. RPP8/HRT
CC subfamily. {ECO:0000305}.
CC -!- CAUTION: Could be the product of a pseudogene. In strain cv. Columbia,
CC a stop codon at position 117 and a naturally occurring frameshift at
CC position 846 result in a truncated LOV1 protein. A complete sequence
CC for LOV1 can be found in strain cv. Cl-0 (AC A7XGN8). {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB65485.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=NIB-LRRS; Note=Functional and comparative genomics
CC of disease resistance gene homologs;
CC URL="http://niblrrs.ucdavis.edu";
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DR EMBL; U95973; AAB65485.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE28663.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE28664.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM59880.1; -; Genomic_DNA.
DR EMBL; AY074545; -; NOT_ANNOTATED_CDS; mRNA.
DR PIR; A86243; A86243.
DR RefSeq; NP_001117266.1; NM_001123794.1.
DR RefSeq; NP_001322203.1; NM_001331943.1.
DR RefSeq; NP_172561.2; NM_100967.3.
DR AlphaFoldDB; O04093; -.
DR SMR; O04093; -.
DR STRING; 3702.AT1G10920.1; -.
DR PaxDb; O04093; -.
DR PRIDE; O04093; -.
DR ProteomicsDB; 238481; -.
DR EnsemblPlants; AT1G10920.1; AT1G10920.1; AT1G10920.
DR EnsemblPlants; AT1G10920.2; AT1G10920.2; AT1G10920.
DR EnsemblPlants; AT1G10920.4; AT1G10920.4; AT1G10920.
DR GeneID; 837635; -.
DR Gramene; AT1G10920.1; AT1G10920.1; AT1G10920.
DR Gramene; AT1G10920.2; AT1G10920.2; AT1G10920.
DR Gramene; AT1G10920.4; AT1G10920.4; AT1G10920.
DR KEGG; ath:AT1G10920; -.
DR Araport; AT1G10920; -.
DR TAIR; locus:2197409; AT1G10920.
DR eggNOG; KOG4658; Eukaryota.
DR HOGENOM; CLU_000837_35_5_1; -.
DR InParanoid; O04093; -.
DR OMA; FINCVGE; -.
DR OrthoDB; 169620at2759; -.
DR PhylomeDB; O04093; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; O04093; baseline and differential.
DR Genevisible; O04093; AT.
DR GO; GO:0005886; C:plasma membrane; IDA:TAIR.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0050832; P:defense response to fungus; IMP:TAIR.
DR GO; GO:0002238; P:response to molecule of fungal origin; IEP:TAIR.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.10.8.430; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; PTHR23155; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 5: Uncertain;
KW Leucine-rich repeat; Plant defense; Reference proteome; Repeat.
FT CHAIN 1..727
FT /note="Putative inactive disease susceptibility protein
FT LOV1"
FT /id="PRO_0000212721"
FT DOMAIN 44..336
FT /note="NB-ARC"
FT REPEAT 459..484
FT /note="LRR 1"
FT REPEAT 485..507
FT /note="LRR 2"
FT REPEAT 509..530
FT /note="LRR 3"
FT REPEAT 575..600
FT /note="LRR 4"
FT REPEAT 601..626
FT /note="LRR 5"
SQ SEQUENCE 727 AA; 83685 MW; 0D9247FFA0519E35 CRC64;
MKSLGIQEII DGASSMSLQE RQREQKEIRQ TFANSSESDL VGVEQSVEAL AGHLVENDNI
QVVSISGMGG IGKTTLARQV FHHDMVQRHF DGFAWVFVSQ QFTQKHVWQR IWQELQPQNG
DISHMDEHIL QGKLFKLLET GRYLVVLDDV WKEEDWDRIK AVFPRKRGWK MLLTSRNEGV
GIHADPKSFG FKTRILTPEE SWKLCEKIVF HRRDETGTLS EVRVDEDMEA MGKEMVTCCG
GLPLAVKVLG GLLATKHTVP EWKRVYDNIG PHLAGRSSLD DNLNSIYRVL SLSYENLPMC
LKHCFLYLAH FPEYYEIHVK RLFNYLAAEG IITSSDDGTT IQDKGEDYLE ELARRNMITI
DKNYMFLRKK HCQMHDMMRE VCLSKAKEEN FLEIFKVSTA TSAINARSLS KSRRLSVHGG
NALPSLGQTI NKKVRSLLYF AFEDEFCILE STTPCFRSLP LLRVLDLSRV KFEGGKLPSS
IGDLIHLRFL SLHRAWISHL PSSLRNLKLL LYLNLGFNGM VHVPNVLKEM QELRYLQLPM
SMHDKTKLEL SDLVNLESLM NFSTKYASVM DLLHMTKLRE LSLFITDGSS DTLSSSLGQL
RSLEVLHLYD RQEPRVAYHG GEIVLNCIHL KELELAIHMP RFPDQYLFHP HLSHIYLWCC
SMEEDPIPIL ERLLHLKSVI LTFGAFVGRR MVCSKGGFPQ LCFLKLEELE ELEEWIVEEG
RCHFFVL
