LOV1B_ARATH
ID LOV1B_ARATH Reviewed; 910 AA.
AC A7XGN8; A9QGV0;
DT 08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 1.
DT 03-AUG-2022, entry version 72.
DE RecName: Full=Disease susceptibility protein LOV1;
DE AltName: Full=Disease resistance protein RPP8-like protein 1;
DE AltName: Full=Protein LONG VEGETATIVE PHASE1;
GN Name=LOV1; Synonyms=RPP8L1;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC STRAIN=cv. Cl-0, and cv. Col-4;
RX PubMed=17804803; DOI=10.1073/pnas.0702572104;
RA Lorang J.M., Sweat T.A., Wolpert T.J.;
RT "Plant disease susceptibility conferred by a 'resistance' gene.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:14861-14866(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND MUTAGENESIS OF GLY-192;
RP ALA-370; GLY-375; ALA-434; PRO-437; GLY-470; ALA-511; LEU-777 AND GLY-822.
RC STRAIN=cv. Bil-5, cv. Landsberg erecta, cv. Lov-1, cv. RRS-10,
RC cv. Rubezhnoe-2, cv. Tol-0, and cv. Yo-0;
RX PubMed=18052878; DOI=10.1094/mpmi-21-1-0007;
RA Sweat T.A., Lorang J.M., Bakker E.G., Wolpert T.J.;
RT "Characterization of natural and induced variation in the LOV1 gene, a CC-
RT NB-LRR gene conferring victorin sensitivity and disease susceptibility in
RT Arabidopsis.";
RL Mol. Plant Microbe Interact. 21:7-19(2008).
RN [3]
RP INDUCTION BY EMF1 AND EMF2.
RX PubMed=19783648; DOI=10.1104/pp.109.143495;
RA Kim S.Y., Zhu T., Sung Z.R.;
RT "Epigenetic regulation of gene programs by EMF1 and EMF2 in Arabidopsis.";
RL Plant Physiol. 152:516-528(2010).
CC -!- FUNCTION: Confers susceptibility to the fungus Cochliobolus victoriae
CC by conditioning victorin-dependent (victorin is a toxin synthesized by
CC C.victoriae) induction of defense-associated proteins.
CC {ECO:0000269|PubMed:17804803, ECO:0000269|PubMed:18052878}.
CC -!- INDUCTION: Repressed by silencing mediated by polycomb group (PcG)
CC protein complex containing EMF1 and EMF2.
CC {ECO:0000269|PubMed:19783648}.
CC -!- DOMAIN: The LRR repeats probably act as specificity determinant of
CC pathogen recognition. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family. RPP8/HRT
CC subfamily. {ECO:0000305}.
CC -!- CAUTION: Has been shown to be a pseudogene in cv. Columbia (AC O04093)
CC due to a stop codon at position 117 and a naturally occurring
CC frameshift at position 846 in this strain. The sequence shown is from
CC strain cv. Cl-0. {ECO:0000305}.
CC -!- WEB RESOURCE: Name=NIB-LRRS; Note=Functional and comparative genomics
CC of disease resistance gene homologs;
CC URL="http://niblrrs.ucdavis.edu";
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DR EMBL; EF472599; ABO69702.1; -; Genomic_DNA.
DR EMBL; EU053655; ABW24143.1; -; Genomic_DNA.
DR EMBL; EU053658; ABW24146.1; -; Genomic_DNA.
DR EMBL; EU053660; ABW24148.1; -; Genomic_DNA.
DR EMBL; EU053664; ABW24152.1; -; Genomic_DNA.
DR EMBL; EU053667; ABW24155.1; -; Genomic_DNA.
DR EMBL; EU053670; ABW24158.1; -; Genomic_DNA.
DR EMBL; EU053675; ABW24163.1; -; Genomic_DNA.
DR EMBL; EU053680; ABW24168.1; -; Genomic_DNA.
DR EMBL; EU053681; ABW24169.1; -; Genomic_DNA.
DR AlphaFoldDB; A7XGN8; -.
DR SMR; A7XGN8; -.
DR DIP; DIP-61887N; -.
DR IntAct; A7XGN8; 2.
DR PRIDE; A7XGN8; -.
DR ExpressionAtlas; A7XGN8; baseline and differential.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006952; P:defense response; IDA:UniProtKB.
DR GO; GO:0009620; P:response to fungus; IDA:UniProtKB.
DR GO; GO:0002238; P:response to molecule of fungal origin; IDA:UniProtKB.
DR CDD; cd14798; RX-CC_like; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.10.8.430; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038005; RX-like_CC.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; PTHR23155; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF18052; Rx_N; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 1: Evidence at protein level;
KW ATP-binding; Coiled coil; Leucine-rich repeat; Nucleotide-binding;
KW Plant defense; Repeat.
FT CHAIN 1..910
FT /note="Disease susceptibility protein LOV1"
FT /id="PRO_0000405407"
FT DOMAIN 169..461
FT /note="NB-ARC"
FT REPEAT 584..609
FT /note="LRR 1"
FT REPEAT 610..632
FT /note="LRR 2"
FT REPEAT 634..655
FT /note="LRR 3"
FT REPEAT 700..725
FT /note="LRR 4"
FT REPEAT 726..751
FT /note="LRR 5"
FT REPEAT 847..871
FT /note="LRR 6"
FT COILED 22..60
FT /evidence="ECO:0000255"
FT MUTAGEN 192
FT /note="G->E: Loss of victorin sensitivity."
FT /evidence="ECO:0000269|PubMed:18052878"
FT MUTAGEN 370
FT /note="A->V: Loss of victorin sensitivity."
FT /evidence="ECO:0000269|PubMed:18052878"
FT MUTAGEN 375
FT /note="G->R: Loss of victorin sensitivity."
FT /evidence="ECO:0000269|PubMed:18052878"
FT MUTAGEN 434
FT /note="A->T: Loss of victorin sensitivity."
FT /evidence="ECO:0000269|PubMed:18052878"
FT MUTAGEN 437
FT /note="P->L,S: Loss of victorin sensitivity."
FT /evidence="ECO:0000269|PubMed:18052878"
FT MUTAGEN 470
FT /note="G->E,R: Loss of victorin sensitivity."
FT /evidence="ECO:0000269|PubMed:18052878"
FT MUTAGEN 511
FT /note="A->T: Loss of victorin sensitivity."
FT /evidence="ECO:0000269|PubMed:18052878"
FT MUTAGEN 777
FT /note="L->F: Loss of victorin sensitivity."
FT /evidence="ECO:0000269|PubMed:18052878"
FT MUTAGEN 822
FT /note="G->D: Loss of victorin sensitivity."
FT /evidence="ECO:0000269|PubMed:18052878"
SQ SEQUENCE 910 AA; 104511 MW; FE3A348CB5F98733 CRC64;
MAEGVVLFGV HKLWELLNRE SARLNGIGEQ VDGLKRQLGR LQSLLKDADA KKHESERVRN
FLEDVRDIVY DAEDIIESFL LNEFRTKEKG IKKHARRLAC FLVDRRKFAS DIKGITKKIS
EVIGGMKSLG IQEIIDGASS MSLQERQREQ KEIRQTFANS SESDLVGVEQ SVEALAGHLV
ENDNIQVVSI SGMGGIGKTT LARQVFHHDM VQRHFDGFAW VFVSQQFTQK HVWQRIWQEL
QPQNGDISHM DEHILQGKLF KLLETGRYLV VLDDVWKEED WDRIKAVFPR KRGWKMLLTS
RNEGVGIHAD PKSFGFKTRI LTPEESWKLC EKIVFHRRDE TGTLSEVRVD EDMEAMGKEM
VTCCGGLPLA VKVLGGLLAT KHTVPEWKRV YDNIGPHLAG RSSLDDNLNS IYRVLSLSYE
DLPMCLKHCF LYLAHFPEYY EIHVKRLFNY LAAEGIITSS DDGTTIQDKG EDYLEELARR
NMITIDKNYM FLRKKHCQMH DMMREVCLSK AKEENFLEIF KVSTATSAIN ARSLSKSRRL
SVHGGNALQS LGQTINKKVR SLLYFAFEDE FCILESTTPC FRSLPLLRVL DLSRVKFEGG
KLPSSIGDLI HLRFLSLHRA WISHLPSSLR NLKLLLYLNL GFNGMVHVPN VLKEMQELRY
LQLPMSMHDK TKLELSDLVN LESLMNFSTK YASVMDLLHM TKLRELSLFI TDGSSDTLSS
SLGQLRSLEV LHLYDRQEPR VAYHGGEIVL NCIHLKELEL AIHMPRFPDQ YLFHPHLSHI
YLWCCSMEED PIPILERLLH LKSVILTFGA FVGRRMVCSK GGFPQLCFLK LEELEELEEW
IVEEGSMPLL RALTICNCRK LKLPGGINYI TSLKELTIVG MKWKEKLVPG GEDYYKVQNI
PNVQFINCDE