ID   LOV1C_ARATH             Reviewed;         910 AA.
AC   A9QGV6;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Inactive disease susceptibility protein LOV1;
DE   AltName: Full=Disease resistance protein RPP8-like protein 1;
DE   AltName: Full=Protein LONG VEGETATIVE PHASE1;
GN   Name=LOV1; Synonyms=RPP8L1;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=cv. Bay-0;
RX   PubMed=18052878; DOI=10.1094/mpmi-21-1-0007;
RA   Sweat T.A., Lorang J.M., Bakker E.G., Wolpert T.J.;
RT   "Characterization of natural and induced variation in the LOV1 gene, a CC-
RT   NB-LRR gene conferring victorin sensitivity and disease susceptibility in
RT   Arabidopsis.";
RL   Mol. Plant Microbe Interact. 21:7-19(2008).
CC   -!- SIMILARITY: Belongs to the disease resistance NB-LRR family. RPP8/HRT
CC       subfamily. {ECO:0000305}.
CC   -!- CAUTION: Has been shown to confer susceptibility to the fungus
CC       Cochliobolus victoriae by conditioning victorin-dependent (victorin is
CC       a toxin synthesized by C.victoriae) induction of defense-associated
CC       proteins in cv. Cl-0 (AC A7XGN8). In strain cv. Bay-0, 2 variations at
CC       positions 228 (Thr -> Ala) and 538 (Arg -> Ser) result in an inactive
CC       LOV1 protein regarding sensitivity to victorin. The sequence shown is
CC       from strain cv. Bay-0, a complete sequence for LOV1 can be found in
CC       strain cv. Cl-0 (AC A7XGN8). {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=NIB-LRRS; Note=Functional and comparative genomics
CC       of disease resistance gene homologs;
CC       URL="http://niblrrs.ucdavis.edu";
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DR   EMBL; EU053661; ABW24149.1; -; Genomic_DNA.
DR   AlphaFoldDB; A9QGV6; -.
DR   SMR; A9QGV6; -.
DR   ExpressionAtlas; A9QGV6; baseline and differential.
DR   GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR   CDD; cd14798; RX-CC_like; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.8.430; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   Gene3D; 3.80.10.10; -; 2.
DR   InterPro; IPR042197; Apaf_helical.
DR   InterPro; IPR044974; Disease_R_plants.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR002182; NB-ARC.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR038005; RX-like_CC.
DR   InterPro; IPR041118; Rx_N.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR23155; PTHR23155; 1.
DR   Pfam; PF00931; NB-ARC; 1.
DR   Pfam; PF18052; Rx_N; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Coiled coil; Leucine-rich repeat; Nucleotide-binding;
KW   Plant defense; Repeat.
FT   CHAIN           1..910
FT                   /note="Inactive disease susceptibility protein LOV1"
FT                   /id="PRO_0000405408"
FT   DOMAIN          169..461
FT                   /note="NB-ARC"
FT   REPEAT          584..609
FT                   /note="LRR 1"
FT   REPEAT          610..632
FT                   /note="LRR 2"
FT   REPEAT          634..655
FT                   /note="LRR 3"
FT   COILED          22..60
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   910 AA;  104426 MW;  46E1F141719AB61D CRC64;
     MAEGVVLFGV HKLWELLNRE SARLNGIGEQ VDGLKRQLGR LQSLLKDADA KKHESERVRN
     FLEDVRDIVY DAEDIIESFL LNEFRAKEKG IKKHARRLAC FLVDRRKFDS DIKGITKKIS
     EVIGGMKSLG IQEIIDGASS MSLQERQREQ KEIRQTFANS SESDLVGVEQ SVEALAGHLV
     ENDNIQVVSI SGMGGIGKTT LARQVFHHDM VQRHFDGFAW VFVSQQFAQK HVWQRIWQEL
     QPQNGDISHM DEHILQGKLF KLLETGRYLV VLDDVWKEED WDRIKAVFPR KRGWKMLLTS
     RNEGVGIHAD PKSFGFKTRI LTPEESWKLC EKIVFHRRDE TGTLSEVRVD EDMEAMGKEM
     VTCCGGLPLA VKVLGGLLAT KHTVPEWKRV YDNIGPHLAG RSSLDDNLNS IYRVLSLSYE
     DLPMCLKHCF LYLAHFPEYY EIHVKRLFNY LAAEGIITSS DDGTTIQDKG EDYLEELARR
     NMITIDKNYM FLRKKHCQMH DMMREVCLSK AKEENFLEIF KVSTATSAIN ARSLSKSSRL
     SVHGGNALQS LGQTINKKVR SLLYFAFEDE FCILESTTPC FRSLPLLRVL DLSRVKFEGG
     KLPSSIGDLI HLRFLSLHRA WISHLPSSLR NLKLLLYLNL GFNGMVHVPN VLKEMQELRY
     LQLPMSMHDK TKLELSDLVN LESLMNFSTK YASVMDLLHM TKLRELSLFI TDGSSDTLSS
     SLGQLRSLEV LHLYDRQEPR VAYHGGEIVL NCIHLKELEL AIHMPRFPDQ YLFHPHLSHI
     YLWCCSMEED PIPILERLLH LKSVILTFGA FVGRRMVCSK GGFPQLCFLK LEELEELEEW
     IVEEGSMPLL RALTICNCRK LKLPGGINYI TSLKELTIVG MKWKEKLVPG GEDYYKVQNI
     PNVQFINCDE