ID   LOVG_AEDAE              Reviewed;         275 AA.
AC   Q0C7C4;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Esterase AAEL000016;
DE            EC=3.1.2.- {ECO:0000305};
GN   ORFNames=AAEL000016;
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LVPib12;
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA   Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA   Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA   Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA   Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA   El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA   Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA   Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA   Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA   Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA   Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA   Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA   Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
CC   -!- SIMILARITY: Belongs to the LovG family. {ECO:0000305}.
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DR   EMBL; CH477186; EAT48902.1; -; Genomic_DNA.
DR   RefSeq; XP_001647845.1; XM_001647795.1.
DR   AlphaFoldDB; Q0C7C4; -.
DR   SMR; Q0C7C4; -.
DR   STRING; 7159.AAEL000016-PA; -.
DR   ESTHER; aedae-u483; FSH1.
DR   GeneID; 5563630; -.
DR   KEGG; aag:5563630; -.
DR   VEuPathDB; VectorBase:AAEL000016; -.
DR   eggNOG; KOG2551; Eukaryota.
DR   HOGENOM; CLU_051938_2_3_1; -.
DR   InParanoid; Q0C7C4; -.
DR   OMA; EEPTVCR; -.
DR   OrthoDB; 1190789at2759; -.
DR   PhylomeDB; Q0C7C4; -.
DR   Proteomes; UP000008820; Chromosome 1.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR005645; FSH_dom.
DR   Pfam; PF03959; FSH1; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Reference proteome.
FT   CHAIN           1..275
FT                   /note="Esterase AAEL000016"
FT                   /id="PRO_0000300880"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          253..275
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..18
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        129
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250|UniProtKB:P38777"
FT   ACT_SITE        187
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250|UniProtKB:P38777"
FT   ACT_SITE        214
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250|UniProtKB:P38777"
SQ   SEQUENCE   275 AA;  29976 MW;  B45F8CBEAFB79EDC CRC64;
     MMANETAAKS TKSSPTPAVE PESKLKILAL HGYRQNGDGF KSKLGSFRKF IGKHAELVFV
     TAPHIAPPLP DSEAGTEPDP AQRSWWFNKD DGTFKGTNKN GPAIGFEDSL KLVEKVWKQE
     QCCGLLGFSQ GACFVGLLCD LSARGMTSIK PEFAVLSSGF RSGSLVHLNC YETKVQIPSL
     HIYGEADEII PKEMSMALAD TFTDPQILTH PGGHFLPAQA SQKQTYVEFF RERLQFHLEA
     QEIENATAAN SILVDDSGPA GNGVHDDDDD DDDSD