LOVHK_BRUC2
ID LOVHK_BRUC2 Reviewed; 489 AA.
AC A9MBM8;
DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT 20-JAN-2009, sequence version 2.
DT 03-AUG-2022, entry version 69.
DE RecName: Full=Blue-light-activated histidine kinase;
DE EC=2.7.13.3;
GN OrderedLocusNames=BCAN_B0589;
OS Brucella canis (strain ATCC 23365 / NCTC 10854).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX NCBI_TaxID=483179;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 23365 / NCTC 10854;
RA Setubal J.C., Bowns C., Boyle S., Crasta O.R., Czar M.J., Dharmanolla C.,
RA Gillespie J.J., Kenyon R.W., Lu J., Mane S., Mohapatra S., Nagrani S.,
RA Purkayastha A., Rajasimha H.K., Shallom J.M., Shallom S., Shukla M.,
RA Snyder E.E., Sobral B.W., Wattam A.R., Will R., Williams K., Yoo H.,
RA Bruce D., Detter C., Munk C., Brettin T.S.;
RT "Brucella canis ATCC 23365 whole genome shotgun sequencing project.";
RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Photosensitive kinase that is involved in increased bacterial
CC virulence upon exposure to light. Once ejected from an infected animal
CC host, sunlight acts as an environmental signal that increases the
CC virulence of the bacterium, preparing it for infection of the next
CC host. This photoreceptor protein is directly related to the bacterium's
CC survival and replication within host macrophages (By similarity).
CC {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3;
CC -!- PTM: FMN binds covalently to cysteine after exposure to blue light and
CC this bond is spontaneously broken in the dark. {ECO:0000250}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABX63765.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; CP000873; ABX63765.1; ALT_INIT; Genomic_DNA.
DR RefSeq; WP_002971240.1; NC_010104.1.
DR AlphaFoldDB; A9MBM8; -.
DR SMR; A9MBM8; -.
DR EnsemblBacteria; ABX63765; ABX63765; BCAN_B0589.
DR GeneID; 45053625; -.
DR GeneID; 55592260; -.
DR KEGG; bcs:BCAN_B0589; -.
DR HOGENOM; CLU_000445_114_57_5; -.
DR Proteomes; UP000001385; Chromosome II.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0009881; F:photoreceptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004673; F:protein histidine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR CDD; cd00130; PAS; 2.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013655; PAS_fold_3.
DR InterPro; IPR011102; Sig_transdc_His_kinase_HWE.
DR Pfam; PF07536; HWE_HK; 1.
DR Pfam; PF08447; PAS_3; 1.
DR Pfam; PF13426; PAS_9; 1.
DR SMART; SM00911; HWE_HK; 1.
DR SMART; SM00086; PAC; 2.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF55785; SSF55785; 2.
DR TIGRFAMs; TIGR00229; sensory_box; 2.
DR PROSITE; PS50113; PAC; 2.
DR PROSITE; PS50112; PAS; 1.
PE 3: Inferred from homology;
KW ATP-binding; Chromophore; Flavoprotein; FMN; Kinase; Nucleotide-binding;
KW Phosphoprotein; Photoreceptor protein; Receptor; Repeat;
KW Sensory transduction; Transferase; Virulence.
FT CHAIN 1..489
FT /note="Blue-light-activated histidine kinase"
FT /id="PRO_0000361284"
FT DOMAIN 19..93
FT /note="PAS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00140"
FT DOMAIN 93..147
FT /note="PAC 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00141"
FT DOMAIN 232..281
FT /note="PAC 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00141"
FT REGION 285..367
FT /note="HWE histidine kinase domain"
FT MOD_RES 69
FT /note="S-4a-FMN cysteine"
FT /evidence="ECO:0000250"
FT MOD_RES 288
FT /note="Phosphohistidine; by autocatalysis"
FT /evidence="ECO:0000250"
SQ SEQUENCE 489 AA; 54874 MW; 6F2A04467FB26C5B CRC64;
MAIDLRPFIP FGRGALSQAT DPFRAAVEFT LMPMLITNPH LPDNPIVFAN PAFLKLTGYE
ADEVMGRNCR FLQGHGTDPA HVRAIKSAIA AEKPIDIDII NYKKSGEAFW NRLHISPVHN
ANGRLQHFVS SQLDVTLELS RLVELEKERK TLSIETARSK DQLDYIVEVA NIGFWTREFY
SGKMTCSAEC RRIYGFTPDE PVHFDTILDL VVLEDRMTVV QKAHQAVTGE PYSIEYRIVT
RLGETRWLET RAKALTGENP LVLGIVQDVT ERKKAEANKA LVSREIAHRF KNSMAMVQSI
ANQTLRNTYD PEQANRLFSE RLRALSQAHD MLLKENWAGA TIQQICATAL APFNSTFANR
IHMSGPHLLV SDRVTVALSL AFYELATNAV KYGALSNEKG VINITWAIME DKGEKKFHMR
WAESRGPEVM QPARRGFGQR LLHSVLAEEL KAKCDVEFAA SGLLIDVLAP ITPEVFPGMG
HNVPEQRIA